Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Simon P, Langdon"'
Autor:
Sarah J. Taylor, Robert L. Hollis, Charlie Gourley, C. Simon Herrington, Simon P. Langdon, Mark J. Arends
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenan
Externí odkaz:
https://doaj.org/article/0f37cae0814847a1b8d645d8c736be1e
Autor:
Kate M. Moore, Vera Cerqueira, Kenneth G. MacLeod, Peter Mullen, Richard L. Hayward, Simon Green, David J. Harrison, David A. Cameron, Simon P. Langdon
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1, Pp 97-116 (2022)
Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation. Methods: The MCF7 breast cancer model is sensitive to estrogens and anti-estrog
Externí odkaz:
https://doaj.org/article/1befcc865c8d466aa9837be2e933674b
Autor:
Wang, Fen
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal, 2003 Nov 01. 39(10), 476-476.
Externí odkaz:
https://www.jstor.org/stable/4295508
Autor:
Carol Ward, James Meehan, Mark E Gray, Alan F Murray, David J Argyle, Ian H Kunkler, Simon P Langdon
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 2, Pp 71-100 (2020)
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety
Externí odkaz:
https://doaj.org/article/433acbca338740a690220966460cdf67
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 1, Pp 26-52 (2020)
The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of ovarian and other cancers which rely extensively on
Externí odkaz:
https://doaj.org/article/0ee6932f74224f3fb52ad84bc51ff6d4
Autor:
Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray, David Argyle
Publikováno v:
Radiation Oncology, Vol 14, Iss 1, Pp 1-19 (2019)
Abstract Background Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation by cells that have dev
Externí odkaz:
https://doaj.org/article/f86ee81a892849e88ed5db0ce297194d
Autor:
Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-18 (2019)
Abstract Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whos
Externí odkaz:
https://doaj.org/article/923a851c858a45a7b0788fc90b57314e
Publikováno v:
Cancer Biology & Medicine, Vol 15, Iss 4, Pp 375-388 (2018)
Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors (especially HER1/EGFR and HER2/ERBB2) are i
Externí odkaz:
https://doaj.org/article/1d146730240b467ea7e888ab13b5e50d
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 2 (2021)
Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell’s response to oxidative and electrophilic stress and is a transcription factor regulating the expression of a collection of anti-oxidative and cytoprotective gen
Externí odkaz:
https://doaj.org/article/2b3b888a450a4c6abc381c6ffe28e8fd
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 14 (2020)
Background: Triple-negative breast cancer is an aggressive type of breast cancer with high risk of recurrence. It is still poorly understood and lacks any targeted therapy, which makes it difficult to treat. Thus, it is important to understand the un
Externí odkaz:
https://doaj.org/article/c841407e1b0c4380957860ec53d91da8