Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Simon O Clark"'
Autor:
Joanna Bacon, Luke J Alderwick, Jon A Allnutt, Evelina Gabasova, Robert Watson, Kim A Hatch, Simon O Clark, Rose E Jeeves, Alice Marriott, Emma Rayner, Howard Tolley, Geoff Pearson, Graham Hall, Gurdyal S Besra, Lorenz Wernisch, Ann Williams, Philip D Marsh
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87329 (2014)
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental cond
Externí odkaz:
https://doaj.org/article/c11cea27e6004c5da7415a8a6a12a1b4
Autor:
Graham Hall, Owen Daykin-Pont, Helen McShane, Simon O. Clark, Sally A. Sharpe, Ann Williams, Ashley Jacobs, Lisa M. Stevens, Laura Sibley, Fergus V. Gleeson, Michael Dennis, Philip Marsh, Karen E. Gooch, Rachel Tanner, Geoff Pearson, Anthony McIntyre, Andrew D. White, Randall J. Basaraba, Emma L. Rayner
This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57d6051c6d3026e1c3298970c863f2a
https://doi.org/10.21203/rs.3.rs-296520/v1
https://doi.org/10.21203/rs.3.rs-296520/v1
Autor:
Jérôme Nigou, Claudia Nobrega, Germain Puzo, Sílvia Vale-Costa, Simon O. Clark, Roy Ummels, Ann Williams, A. Afonso-Barroso, Farahnaz Movahedzadeh, Arjen Sloots, P. van der Ley, Jeroen Geurtsen, G.T. Rosa, Rui Appelberg, Sandro Silva-Gomes, B.J. Appelmelk, Neil G. Stoker, Marlène Cot
Publikováno v:
Cellular Microbiology. 15:660-674
Mannose-capped lipoarabinomannan (ManLAM) is considered an important virulence factor of Mycobacterium tuberculosis. However, while mannose caps have been reported to be responsible for various immunosuppressive activities of ManLAM observed in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30e03f5c8590ff263502121f1d3ffe4
https://doi.org/10.1111/cmi.12065
https://doi.org/10.1111/cmi.12065
Autor:
Mark A. Chambers, Julia A. Tree, N. Baker, Ann Williams, S. Smith, Philip Marsh, Frank E. Aldwell, Simon O. Clark
Publikováno v:
Letters in Applied Microbiology. 55:295-300
Aims: We sought to develop a new method that enables the assessment of the immune response of guinea pigs during TB vaccine evaluation studies, without the need to cull or anaesthetize animals. Method and Results: Guinea pigs were vaccinated with fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4ca048bf1d616cc8b62496b389199d
https://doi.org/10.1111/j.1472-765x.2012.03292.x
https://doi.org/10.1111/j.1472-765x.2012.03292.x
Publikováno v:
Journal of Applied Microbiology. 111:350-359
Aims: We undertook a series of experiments to investigate factors that contribute to variation in Mycobacterium tuberculosis viability and infectivity, during experimental aerosolization, with an aim to optimize a strategy to enable a more reproducib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46fdaadc33a436fe44af85dd3fc91c83
https://doi.org/10.1111/j.1365-2672.2011.05069.x
https://doi.org/10.1111/j.1365-2672.2011.05069.x
Autor:
Ian M. Orme, Randall J. Basaraba, Ann Williams, Simon O. Clark, Graham Hall, Karen E. Gooch, Susan L. Kraft, George F. Rick Hatch, A. McIntyre, Mike Dennis, E. Eschelbach, Sally Sharpe, Fergus V. Gleeson, Philip Marsh
Publikováno v:
Tuberculosis. 89:405-416
Sensitive and reproducible methods are needed to measure the impact on the host following experimental challenge with Mycobacterium tuberculosis, in order to determine the degree of protection conferred by new vaccines. Here we compare how well diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf41f85f2641e0706763f01d2905819
https://doi.org/10.1016/j.tube.2009.09.002
https://doi.org/10.1016/j.tube.2009.09.002
Autor:
Lindsay J. Hall, Philip Marsh, Christine Hale, Derek Pickard, Peter Andersen, Jes Dietrich, Moataz Abd El Ghany, Gordon Dougan, Simon O. Clark, Dominic L.F. Kelly, Simon Clare
Publikováno v:
Vaccine
A recombinant Salmonella enterica serovar Typhimurium (S. Typhimurium) vaccine strain was constructed that stably expressed the Mycobacterium tuberculosis fusion antigen Ag85B-ESAT6 from the chromosome. Live oral vaccination of mice with the Salmonel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babafb24eefbc71a14d63b7f8b6138c4
Autor:
Edgar Badell, Nathalie Winter, Brigitte Gicquel, Luiz R.R. Castello-Branco, Simon O. Clark, Fabienne Nicolle, Laleh Majlessi, Frédéric Boudou, Philip Marsh, David Lewis, Claude Leclerc, Angelo Martino
Publikováno v:
Vaccine
Vaccine, Elsevier, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩
Vaccine, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩
Vaccine, Elsevier, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩
Vaccine, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩
International audience; The potent IFN-gamma inducing fusion antigen Ag8513-ESAT-6 (85136) is a lead subunit candidate to improve current vaccination against Mycobacterium tuberculosis (Mtb). The recombinant M. bovis BCG strain Myc3504 was constructe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076d3bb22fc56b1afb91c91c598c9763
https://doi.org/10.1016/j.vaccine.2008.10.034
https://doi.org/10.1016/j.vaccine.2008.10.034
Autor:
Nigel P. Minton, Ann Williams, Simon O. Clark, Helen Shuttleworth, Graham J. Hatch, Emma Allen-Vercoe, Philip Marsh, Karen Blake, Joanna Bacon, Toby Hampshire, Julia Vipond, Richard Vipond, Karen E. Gooch
Publikováno v:
Vaccine. 24:6340-6350
Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2f444df30343a1281e9d0fbef0b6b1
https://doi.org/10.1016/j.vaccine.2006.05.025
https://doi.org/10.1016/j.vaccine.2006.05.025
Autor:
Julia Vipond, Richard Vipond, Julia A. Tree, Philip Marsh, Else Marie Agger, Ann Williams, Simon O. Clark, Graham J. Hatch
Publikováno v:
Tuberculosis. 86:218-224
Summary A selection of previously identified protective Mycobacterium tuberculosis DNA vaccines were re-formulated as proteins and administered with a Th1-inducing adjuvant to help stimulate the relevant immune responses necessary for protection. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ce0d0390a8e6cf29574b871d96ce9c
https://doi.org/10.1016/j.tube.2006.01.014
https://doi.org/10.1016/j.tube.2006.01.014