Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Simon O'Connor"'
Autor:
Chey Loveday, Kevin Litchfield, Paula Z. Proszek, Alex J. Cornish, Flavia Santo, Max Levy, Geoff Macintyre, Amy Holryod, Peter Broderick, Darshna Dudakia, Barbara Benton, Maise Al Bakir, Crispin Hiley, Emily Grist, Charles Swanton, Robert Huddart, Tom Powles, Simon Chowdhury, Janet Shipley, Simon O’Connor, James D. Brenton, Alison Reid, David Gonzalez de Castro, Richard S. Houlston, Clare Turnbull
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-
Externí odkaz:
https://doaj.org/article/fd830b167ba2414b9bc17a0f92cc02a5
Autor:
George Gabriel Bitar, Simon O'Connor, Ayoma D. Attygalle, Dima El‐Sharkawi, Sunil Iyengar, Bhupinder Sharma
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 305-306 (2021)
Externí odkaz:
https://doaj.org/article/ad26fa0b8be343efac1b09b630d5119d
Autor:
Graham Brown, Gosia Mikołajczak, Anthony Lyons, Jennifer Power, Fraser Drummond, Aaron Cogle, Brent Allan, Craig Cooper, Simon O’Connor
Publikováno v:
BMC Public Health, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Advances in medical treatment for HIV are driving major changes in HIV policy and practice, including the encouragement of intake and adherence to HIV antiretroviral treatment (ART) by people living with HIV (PLHIV) for both perso
Externí odkaz:
https://doaj.org/article/c306f007f1fb4a8bad04120e2345c7cf
Autor:
Kevin Litchfield, Max Levy, Darshna Dudakia, Paula Proszek, Claire Shipley, Sander Basten, Elizabeth Rapley, D. Timothy Bishop, Alison Reid, Robert Huddart, Peter Broderick, David Gonzalez de Castro, Simon O'Connor, Rachel H. Giles, Richard S. Houlston, Clare Turnbull
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.
Externí odkaz:
https://doaj.org/article/5514be44ed294c9ca7423b116df904dc
Autor:
Lucy Collins, Simon O'Connor
Publikováno v:
Irish University Review. 51:189-199
Autor:
Alex J. Cornish, Barbara Benton, Chey Loveday, Robert Huddart, James D. Brenton, Paula Proszek, Max Levy, Clare Turnbull, Peter Broderick, Charles Swanton, Richard S. Houlston, Janet Shipley, Maise Al Bakir, Kevin Litchfield, Emily Grist, Simon Chowdhury, Flavia Santo, Amy Holryod, Crispin T. Hiley, Alison Reid, Thomas Powles, Simon O'Connor, Geoff Macintyre, David Gonzalez de Castro, Darshna Dudakia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Loveday, C, Litchfield, K, Proszek, P Z, Cornish, A J, Santo, F, Levy, M, Macintyre, G, Holryod, A, Broderick, P, Dudakia, D, Benton, B, Bakir, M A, Hiley, C, Grist, E, Swanton, C, Huddart, R, Powles, T, Chowdhury, S, Shipley, J, O'Connor, S, Brenton, J D, Reid, A, de Castro, D G, Houlston, R S & Turnbull, C 2020, ' Genomic landscape of platinum resistant and sensitive testicular cancers ', Nature Communications, vol. 11, no. 1, pp. 2189 . https://doi.org/10.1038/s41467-020-15768-x
Nature Communications
Loveday, C, Litchfield, K, Proszek, P Z, Cornish, A J, Santo, F, Levy, M, Macintyre, G, Holryod, A, Broderick, P, Dudakia, D, Benton, B, Bakir, M A, Hiley, C, Grist, E, Swanton, C, Huddart, R, Powles, T, Chowdhury, S, Shipley, J, O'Connor, S, Brenton, J D, Reid, A, de Castro, D G, Houlston, R S & Turnbull, C 2020, ' Genomic landscape of platinum resistant and sensitive testicular cancers ', Nature Communications, vol. 11, no. 1, pp. 2189 . https://doi.org/10.1038/s41467-020-15768-x
Nature Communications
While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tu
Autor:
Simon O'Connor
Publikováno v:
Lancet (London, England)
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomise
Autor:
David Cunningham, Katherine Vroobel, Simon O'Connor, Bhupinder Sharma, Ayoma D. Attygalle, Andrew Wotherspoon, Dorte Wren
Publikováno v:
Histopathology. 75:287-290
Autor:
George Bitar, Simon O'Connor, Dima El-Sharkawi, Sunil Iyengar, Bhupinder Sharma, Ayoma D. Attygalle
Publikováno v:
EJHaem. 2(2)
Autor:
Ayoma D. Attygalle, Ming-Qing Du, Bhupinder Sharma, Rachel Dobson, David Cunningham, Katherine Vroobel, Simon O'Connor, Andrew Wotherspoon, Dorte Wren
Publikováno v:
HistopathologyReferences. 78(3)