Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Simon Njenga"'
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Akademický článek
Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial.
Autor: Monique Wasunna, Simon Njenga, Manica Balasegaram, Neal Alexander, Raymond Omollo, Tansy Edwards, Thomas P C Dorlo, Brima Musa, Mohammed Hassan Sharaf Ali, Mohammed Yasein Elamin, George Kirigi, Rashid Juma, Anke E Kip, Gerard J Schoone, Asrat Hailu, Joseph Olobo, Sally Ellis, Robert Kimutai, Susan Wells, Eltahir Awad Gasim Khalil, Nathalie Strub Wourgaft, Fabiana Alves, Ahmed Musa
Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004880 (2016)
BACKGROUND:SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India,
Externí odkaz: https://doaj.org/article/8f00c7ff8e114d8499c8306afaf2b491
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3
Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study
Autor: Simon Njenga, G. Kirigi, Asrat Hailu, Ahmed Eleojo Musa, Monique Wasunna, Joseph Olobo, Thomas P. C. Dorlo, Manica Balasegaram, Eltahir A G Khalil, Mats O. Karlsson, Anke E. Kip, Brima M. Younis, Jos H. Beijnen, Fabiana Alves, Sally Ellis
Publikováno v: Journal of Antimicrobial Chemotherapy
Background: Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. Objectives: To describe the pharmacokinetics and establish a pharmacokinetic/pharmacodynamic relationship for miltefosine in E
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e370f56f0e35af7a84f95c232cbafbe
http://europepmc.org/articles/PMC5890687
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4
Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial
Autor: Manica Balasegaram, Neal Alexander, Anke E. Kip, Mohammed Hassan Sharaf Ali, Eltahir A G Khalil, Gerard J. Schoone, Simon Njenga, Sally Ellis, Susan Wells, Thomas P. C. Dorlo, Robert Kimutai, Monique Wasunna, Joseph Olobo, Asrat Hailu, Fabiana Alves, Raymond Omollo, Brima Musa, Nathalie Strub Wourgaft, Mohammed Yasein Elamin, G. Kirigi, Ahmed Eleojo Musa, Rashid Juma, Tansy Edwards
Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004880 (2016)
PLoS Neglected Tropical Diseases, 10(9), 1. Public Library of Science
PLoS Neglected Tropical Diseases
Background SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40948c6b3808f106f5666edd27cf699
http://europepmc.org/articles/PMC5023160?pdf=render
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5
HLA-A and HLA-B in Kenya, Africa: Allele frequencies and identification of HLA-B*1567 and HLA-B*4426
Autor: Ma Luo, S. Ramdahin, Francis A. Plummer, Joanne Embree, Job B. Bwayo, S. Pan, Simon Njenga, Mary Cheang, Robert C. Brunham, Jeckoniah O. Ndinya-Achola, Xiaojuan Mao, T. Stuart
Publikováno v: Tissue Antigens. 59:370-380
HLA-A and HLA-B alleles of a population from Kenya, Africa were examined by sequencing exon 2 and exon 3 DNA and typing using a Taxonomy-based Sequence-analysis (TBSA) method. Extensive diversities were observed at both HLA-A and HLA-B loci in this p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ac46ee8a9fb3b0632b483da7469e8de
https://doi.org/10.1034/j.1399-0039.2002.590503.x
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6
Lymphocyte subsets in human immunodeficiency virus type 1-infected and uninfected children in Nairobi
Autor: Nico J. D. Nagelkerke, Simon Njenga, Jeckoniah O. Ndinya-Achola, Francis A. Plummer, HO Pamba, Joanne Embree, Patrick M. Nyange, Job J. Bwayo
Publikováno v: The Pediatric Infectious Disease Journal. 20:397-403
Background. Reference lymphocyte subset values for African children are lacking. This study documents these values as well as their alterations associated with perinatal and postnatal HIV-1 transmission and with protection from HIV-1 infection. Metho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904fa7c07240af9a50510ef51c9029a8
https://doi.org/10.1097/00006454-200104000-00006
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7
The HLA A2/6802 Supertype Is Associated with Reduced Risk of Perinatal Human Immunodeficiency Virus Type 1 Transmission
Autor: Joanne Embree, Susie Ramhadin, Francis A. Plummer, Kelly S. MacDonald, Jose Castillo, JO Ndinya-Achola, Julius Oyug, Nico Nagelkerke, Brian H. Barber, Simon Njenga, Job J. Bwayo
Publikováno v: The Journal of Infectious Diseases. 183:503-506
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ede69e55af6f7a8c4d226bba1e2d976
https://doi.org/10.1086/318092
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8
Mother‐Child Class I HLA Concordance Increases Perinatal Human Immunodeficiency Virus Type 1 Transmission
Autor: Job J. Bwayo, Brian H. Barber, Kelly S. MacDonald, Joanne Embree, Nico J. D. Nagelkerke, Jeckoniah O. Ndinya-Achola, Irene Ngatia, Francis A. Plummer, Simon Njenga, Zeena Mohammed
Publikováno v: The Journal of Infectious Diseases. 177:551-556
Major histocompatibility complex (MHC) gene products are expressed on human immunodeficiency virus (HIV)-infected cells and incorporated into the lipid envelope of HIV virions. Macaques immunized with human MHC gene products are protected from simian
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78c332eb009a86d711d64f184045c05
https://doi.org/10.1086/514243
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9
Anti-HLA Alloantibody Is Found in Children But Does Not Correlate with a Lack of HIV Type 1 Transmission from Infected Mothers
Autor: Simon Njenga, Job J. Bwayo, Francis A. Plummer, Joanne Embree, Nicolaas J. D. Nagelkerke, Mark A. Luscher, Gregory Choy, Kelly S. MacDonald, Brian H. Barber
Publikováno v: AIDS Research and Human Retroviruses. 14:99-107
Searching for mechanisms of natural resistance to HIV infection with which to guide HIV vaccine design, we have examined antibody responses to HLA class I antigens in children of HIV-1-infected mothers. Anti-HLA antibodies are known to block HIV infe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e226084839dd1d7882d07c691f7a24
https://doi.org/10.1089/aid.1998.14.99
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10
Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya
Autor: Manica Balasegaram, Joke van Peteghem, Roberto de la Tour, Mark Riongoita, Rashid Juma, G. Kirigi, Simon Njenga, Adrian Laussermayer, François Chappuis, Raymond Omollo, Jane Mbui, Monique Wasunna
Publikováno v: PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases, Vol. 7, No 9 (2013) P. e2441
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2441 (2013)
Background Visceral leishmaniasis (VL) is a systemic parasitic disease that is fatal unless treated. In Kenya, national VL guidelines rely on microscopic examination of spleen aspirate to confirm diagnosis. As this procedure is invasive, it cannot be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693ee7fad4f160b45c77e559f48ead26
https://pubmed.ncbi.nlm.nih.gov/24086782
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