Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Simon N. Willis"'
Autor:
Stephanie Trezise, Isabella Y. Kong, Edwin D. Hawkins, Marco J. Herold, Simon N. Willis, Stephen L. Nutt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHumoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to antibody-mediated autoimmune diseases, while impaired differentiation results in immuno
Externí odkaz:
https://doaj.org/article/57eb21cc2404438bab0ee3cd1555bae6
Autor:
Simon N. Willis, Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O’Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M. Tarlinton, Stephen L. Nutt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, thr
Externí odkaz:
https://doaj.org/article/37dfa3d4d0b943728cbf40939c1d7a57
Autor:
Michael Sze Yuan Low, Erica J. Brodie, Pasquale L. Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N. Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O’Donnell, Catherine Pitt, Stephen L. Nutt, David Tarlinton
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2634-2645.e5 (2019)
Summary: The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. The mechanism by which IRF4 exerts its action in mature plasma cells has been elusive due to the death
Externí odkaz:
https://doaj.org/article/2e3ad701df4e46b6a95d81eadca8710a
Autor:
Francisca F. Almeida, Sara Tognarelli, Antoine Marçais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zöller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. Chiocchetti, Sophie Ugolini, Marco J. Herold, Wei Shi, Joachim Koch, Alexander Steinle, Eric Vivier, Thierry Walzer, Gabrielle T. Belz, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 7, Iss 10 (2018)
NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we describe a spontaneous p
Externí odkaz:
https://doaj.org/article/8e7af400c12d41358fe2c4876853dbc4
Autor:
Simon N. Willis, Charis E Teh, Yang Liao, Mark F. van Delft, Tania Tan, George Grigoriadis, Lorraine A. O'Reilly, Stephen L. Nutt, David C.S. Huang, Jia-Nan Gong, Julie Tellier, Michael S.Y. Low, Marco J Herold, Yuan Yao, Jacob T. Jackson, Wei Shi, Lin Tai, Pasquale L. Fedele
Publikováno v:
Leukemia. 35:2114-2118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d59ea7ff251473fc859c3cd730164ac9
https://doi.org/10.1038/s41375-020-01078-0
https://doi.org/10.1038/s41375-020-01078-0
Autor:
Isabella Y. Kong, Stephanie Trezise, Amanda Light, Izabela Todorovski, Gisela Mir Arnau, Sreeja Gadipally, David Yoannidis, Kaylene J. Simpson, Xueyi Dong, Lachlan Whitehead, Jessica C. Tempany, Anthony J. Farchione, Amania A. Sheikh, Joanna R. Groom, Kelly L. Rogers, Marco J. Herold, Vanessa L. Bryant, Matthew E. Ritchie, Simon N. Willis, Ricky W. Johnstone, Philip D. Hodgkin, Stephen L. Nutt, Stephin J. Vervoort, Edwin D. Hawkins
Publikováno v:
Cell death and differentiation. 29(12)
High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell function. To identify novel targeted therapeutics to treat immune disorders and haematological malignancies, there is a ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e25fbc31b5dbe412fe94196614b51b1
https://pubmed.ncbi.nlm.nih.gov/35831623
https://pubmed.ncbi.nlm.nih.gov/35831623
Autor:
Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
Publikováno v:
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877
https://hdl.handle.net/1887/3213877
Autor:
Andreas Strasser, Yang Liao, Catherine Pitt, Stephen L. Nutt, David M. Tarlinton, Kristy O'Donnell, Erica J. Brodie, Pasquale L. Fedele, Sarah S. Gabriel, Axel Kallies, Simon N. Willis, Wei Shi, Julie Tellier, George Grigoriadis, Michael Sze Yuan Low
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2634-2645.e5 (2019)
Summary: The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. The mechanism by which IRF4 exerts its action in mature plasma cells has been elusive due to the death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e91fc09876d8d34355d8bdb55f0e179
http://www.sciencedirect.com/science/article/pii/S2211124719314305
http://www.sciencedirect.com/science/article/pii/S2211124719314305
Autor:
Michael B. Stadler, Gerhard Christofori, Fabian Wu, Chun Cao, Stefan Dirnhofer, Stephen L. Nutt, Fengyuan Tang, Mathias Frederiksen, Patrick Matthias, Hubertus Kohler, Barna D. Fodor, Simon N. Willis, Mohamed-Amin Choukrallah, Shuang Song, Jacob T. Jackson
Publikováno v:
Blood. 137(21)
OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell–specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here, we show by chromatin immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a1f6082492ef82cda45a282a68764f
https://pubmed.ncbi.nlm.nih.gov/34042984
https://pubmed.ncbi.nlm.nih.gov/34042984
Autor:
Simon N. Willis, Stephen L. Nutt
Publikováno v:
Current opinion in immunology. 58
The differentiation of B cells into antibody-secreting plasma cells is associated with profound changes in morphology, lifespan, and cellular metabolism that are needed to support high rates of antibody production. These processes are driven by drama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19414ad215882cc4ef066c2f4a36ff6
https://pubmed.ncbi.nlm.nih.gov/31132512
https://pubmed.ncbi.nlm.nih.gov/31132512