Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon N. Haydar"'
Autor:
Simon N. Haydar, Jean Zhang, John Dunlop, Arianna Nencini, Laura Maccari, Elisa Turlizzi, Riccardo Zanaletti, Thomas A. Comery, Chiara Ghiron, Eva Genesio, Iolanda Micco, Cristiana Castaldo
Publikováno v:
European Journal of Medicinal Chemistry. 78:401-418
α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139ec03023d3491022a7083c4d811190
https://doi.org/10.1016/j.ejmech.2014.03.031
https://doi.org/10.1016/j.ejmech.2014.03.031
Autor:
Thomas A. Comery, John Dunlop, Laura Maccari, Eva Genesio, Flora Jow, Carmela Pratelli, Chiara Ghiron, Riccardo Zanaletti, Elisa Turlizzi, Ilaria Ceccarelli, Laura Bettinetti, Iolanda Micco, Carla Scali, Simon N. Haydar, Arianna Nencini, Michela Valacchi, Cristiana Castaldo, Giuseppe Cocconcelli
Publikováno v:
Journal of Medicinal Chemistry. 55:10277-10281
α7 Nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort around previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98800eb6cf37051f3ec70e6b3f324b99
https://doi.org/10.1021/jm3013568
https://doi.org/10.1021/jm3013568
Autor:
Riccardo Zanaletti, John Dunlop, Flora Jow, Laura Maccari, Michela Valacchi, Iolanda Micco, Elisa Turlizzi, Cristiana Castaldo, Giovanni Gaviraghi, Simon N. Haydar, Giuseppe Cocconcelli, Thomas A. Comery, Chiara Ghiron, Laura Bettinetti, Carla Scali, Arianna Nencini
Publikováno v:
Journal of Medicinal Chemistry. 55:4806-4823
Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d0dae84961ada3602bc2ed9d734b4f
https://doi.org/10.1021/jm300247y
https://doi.org/10.1021/jm300247y
Autor:
Simon N. Haydar, A. Paul Krapcho
Publikováno v:
Journal of Heterocyclic Chemistry. 38:1153-1166
The synthesis of 6-chloro-9-nitro-benzothiopyranopyridin-5-ones 2a, 2b and 2c has been accomplished. Chemotype 2d could not be prepared since attempts to cyclize 3-(2-nitro-5-chlorophenoxy)pyridine-2-carboxylic acid (1d) led to the decarboxylation pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0a267b40813e838880032fd3457157
https://doi.org/10.1002/jhet.5570380520
https://doi.org/10.1002/jhet.5570380520
Autor:
Flora Jow, Renza Roncarati, Thomas A. Comery, Karen L. Marquis, Steven M. Grauer, Georg C. Terstappen, Claudine Pulicicchio, Carla Scali, Simon N. Haydar, Chiara Ghiron, John Dunlop, Julie A. Brennan, Rachel L. Navarra, Cody Kelley
Publikováno v:
Psychopharmacology. 218(4)
α7 nicotinic acetylcholine receptor (nAChR) agonists are proposed as candidate agents for the adjunctive treatment of cognitive deficits associated with schizophrenia. Despite the pursuit of such an approach clinically, it is surprising that the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b633953d019e1f497899decfe568ae
https://pubmed.ncbi.nlm.nih.gov/21643676
https://pubmed.ncbi.nlm.nih.gov/21643676
Autor:
Ernesto Menta, Simon N. Haydar, Miles P. Hacker, G. Beggiolin, Starlan Truong-Chiott, A. Paul Krapcho
Publikováno v:
ChemInform. 31
The synthesis of 1- and 2-substituted aza-benzothiopyranoindazoles has been accomplished. The comparisons of the in vitro antitumor activities of the 2-substituted analogues with the benzothiopyranoindazole chemotypes indicate that the positioning of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde038d1ea81bfd2e836139c65f3d7ac
https://doi.org/10.1002/chin.200021140
https://doi.org/10.1002/chin.200021140
Autor:
A. Paul Krapcho, Simon N. Haydar
Publikováno v:
ChemInform. 33
The synthesis of 6-chloro-9-nitro-benzothiopyranopyridin-5-ones 2a, 2b and 2c has been accomplished. Chemotype 2d could not be prepared since attempts to cyclize 3-(2-nitro-5-chlorophenoxy)pyridine-2-carboxylic acid (1d) led to the decarboxylation pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2388910e7483f9a210bc3d738e6832dd
https://doi.org/10.1002/chin.200209148
https://doi.org/10.1002/chin.200209148
Autor:
Simon N. Haydar, G. Beggiolin, Starlan Truong-Chiott, A. Paul Krapcho, Miles P. Hacker, Ernesto Menta
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(3)
The synthesis of 1- and 2-substituted aza-benzothiopyranoindazoles has been accomplished. The comparisons of the in vitro antitumor activities of the 2-substituted analogues with the benzothiopyranoindazole chemotypes indicate that the positioning of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3a0ca35204f288c5643114efd8b01c
https://pubmed.ncbi.nlm.nih.gov/10698460
https://pubmed.ncbi.nlm.nih.gov/10698460
Autor:
A. Paul Krapcho, Simon N. Haydar
Publikováno v:
Heterocyclic Communications. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8612752c0dedd889256e202a3e35f946
https://doi.org/10.1515/hc.1998.4.4.291
https://doi.org/10.1515/hc.1998.4.4.291
Autor:
Simon N. Haydar, A. Paul Krapcho
Publikováno v:
Journal of Heterocyclic Chemistry. 34:1637-1638
Treatment of thioxanthenone 6 with N-(2-dimethylaminoethyl)hydrazine led to the benzothiopyranoin-dazole 3, a novel heterocycle, along with the expected compound 8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104bf44a0bb58ca7989508748d0a866
https://doi.org/10.1002/jhet.5570340542
https://doi.org/10.1002/jhet.5570340542