Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Simon N S Louis"'
Autor:
Simon N S Louis, Michael A Krezel, William J Louis, Laurie T C Chow, Albert G Frauman, Linda Adriana Rezmann, Naghmeh Varghayee
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 16 (2015)
Hypothesis: Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 recep- tor (AT2-receptor) interacting protein identified as ATIP. Introduction: The role of the AT2-receptor in cardiac hypertrophy is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a9880c027d0fcd73b0d8a77dc7688d
https://doi.org/10.1177/1470320313483845
https://doi.org/10.1177/1470320313483845
Autor:
William J Louis, Simon N S Louis, Graham P Jackman, Linda A Rezmann-Vitti, Curtis A. Machida, Brian J Duke, Tracy L. Nero
Publikováno v:
Journal of Medicinal Chemistry. 49:3467-3477
Site-directed mutagenesis and photoaffinity labeling experiments suggest the existence of at least two distinct binding orientations for aryloxypropanolamine competitive antagonists in the beta-adrenergic receptor (beta-AR), one where the aryloxy moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3ece1df11b9c0faa0b22edb0caba29
https://doi.org/10.1021/jm050624l
https://doi.org/10.1021/jm050624l
Autor:
William J. Louis, Linda A Rezmann-Vitti, Tracy L. Nero, Dimitri Iakovidis, Simon N S Louis, Graham P. Jackman, Curtis A. Machida
Publikováno v:
Biochemical Pharmacology. 68:675-688
We investigated the role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)) in agonist binding to, and activation of, the rat beta(1)-adrenergic receptor by comparing pK(i)s and functional responses of W134A, S190A and Y356F mutant receptors to wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f364284f1174e13d7b5f7573045357
https://doi.org/10.1016/j.bcp.2004.04.021
https://doi.org/10.1016/j.bcp.2004.04.021
Autor:
Simon N S Louis, William J. Louis, Linda A Rezmann-Vitti, Dimitri Iakovidis, Tracy L. Nero, Graham P. Jackman
Publikováno v:
European Journal of Medicinal Chemistry. 37:111-125
A series of 36 phenoxypropanolamines was examined to determine the structure--activity relationships of beta-adrenoceptor (beta-AR) antagonists for the human beta(1)-AR. The binding affinities of all the compounds were determined for human beta(1)-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a575a4b10b20a60fd2eea9bbe38464f9
https://doi.org/10.1016/s0223-5234(01)01315-0
https://doi.org/10.1016/s0223-5234(01)01315-0
Publikováno v:
Cardiovascular Drugs and Therapy. 14:565-577
In vitro lipolysis stimulated by low (-)-isoprenaline concentrations (< or =30 nM) in epididymal white adipocytes from Sprague-Dawley rats was inhibited at least 60-80% by the specific beta1-antagonists LK 204-545 and CGP 20712A (1 microM), suggestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff01723da2e3f7e04b2278305fb993d
https://doi.org/10.1023/a:1007838125152
https://doi.org/10.1023/a:1007838125152
Autor:
Felicia M. Colagrande, Graham P. Jackman, Tracy L. Nero, Simon N S Louis, William J Louis, Dimitri Iakovidis
Publikováno v:
European Journal of Medicinal Chemistry. 34:919-937
To further explore the structure-activity relationships of beta-adrenoceptor (beta-AR) antagonists, a series of 25 para-substituted N-isopropylphenoxy-propanolamines were synthesised, nine of which are new compounds. All have been examined for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5f676dccc0435c8fea8a47e478535f
https://doi.org/10.1016/s0223-5234(99)00114-2
https://doi.org/10.1016/s0223-5234(99)00114-2
Autor:
Felicia M. Colagrande, Graham P. Jackman, Linda Adriana Rezmann, William J Louis, Dimitri Iakovidis, Simon N S Louis, Tracy L. Nero
Publikováno v:
European Journal of Medicinal Chemistry. 34:539-548
The synthesis of (±)-1-(3',4'-dihydroxyphenoxy)-3-(3",4"-dimethoxyphenyl)ethylamino-2-propanol hydrochloride, (±)-RO363.HCl, and the ( 2S )-(-)-isomer is described for the first time. The binding affinities for (±)-RO363.HCl, ( 2S )-(-)-RO363.HCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08caa5a1dabc99efbfc531cbf4deec2
https://doi.org/10.1016/s0223-5234(99)80103-2
https://doi.org/10.1016/s0223-5234(99)80103-2
Publikováno v:
European Journal of Pharmacology. 367:431-435
LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd7bef335d169866717fba3ec851d81
https://doi.org/10.1016/s0014-2999(99)00019-9
https://doi.org/10.1016/s0014-2999(99)00019-9
Autor:
Albert G Frauman, Laurie T C Chow, Simon N S Louis, William J Louis, Naghmeh Varghayee, Linda Adriana Rezmann
Publikováno v:
Cancers
Cancers, Vol 3, Iss 4, Pp 3824-3837 (2011)
Cancers; Volume 3; Issue 4; Pages: 3824-3837
Cancers, Vol 3, Iss 4, Pp 3824-3837 (2011)
Cancers; Volume 3; Issue 4; Pages: 3824-3837
Angiotensin II (Ang II), the main effector of the renin angiotensin system, acts upon two distinct transmembrane receptors, the Ang II type 1 and the type 2 (AT2-) receptor, to induce promotion and inhibition of ERK2 phosphorylation. The AT2-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5131c46cc5fdab8a14f4f79d71e8b894
https://pubmed.ncbi.nlm.nih.gov/24213113
https://pubmed.ncbi.nlm.nih.gov/24213113