Výsledky vyhledávání - "Simon N, Muchohi"

Response to diazepam in children with malaria-induced seizures

Autor: Simon N. Muchohi, M L Ikumi, Eric O Ohuma, Gilbert Kokwaro, Newton Crjc.

Publikováno v: Epilepsy Research

Summary Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67bca547b4e055b147a2bf34b37a3a
https://doi.org/10.1016/j.eplepsyres.2008.08.002

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Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions

Autor: Gilbert Kokwaro, Bernhards Ogutu, Simon N. Muchohi, Charles R. Newton, Geoffrey Edwards, Steve A. Ward

AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions. METHODS: Twenty-six children with severe malaria and convulsions lasting >

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d01693c9b9f0b5c5a65d8320de0c65d
https://ora.ox.ac.uk/objects/uuid:6ca480fa-3d36-4673-942a-5742e1a95f98

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A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers

Autor: Roma Chilengi, Gilbert Kokwaro, Evelyn Anabwani, Simon N. Muchohi, Rashid Juma, Alexis Nzila, Hudson A. Lodenyo, Gabriel Mwambingu, Mahfudh Bashraheil, Julie Jemutai, Amina Salim, Ednah Wenwa, George O Oyoo, Tim Niehues, Ahmed M Abdallah, Trudie Lang, Chemtai Kipkeu, Priscilla Nyakundi

Publikováno v: Malaria Journal, Vol 10, Iss 1, p 63 (2011)
Malaria Journal

Background Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic profile of this drug in healthy adult male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca1e191b740fccb138d267b980d07a6
https://ora.ox.ac.uk/objects/uuid:4cadebce-2890-4af7-8e84-6e800f0a107a

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Risk factors associated with the epilepsy treatment gap in Kilifi, Kenya: a cross-sectional study

Autor: Simon N. Muchohi, Christopher Nyundo, Rachael Odhiambo, Caroline K. Mbuba, Peter Odermatt, Charles R. Newton, Julie A. Carter, Fredrick Ibinda, Tansy Edwards, Anthony K. Ngugi, Greg Fegan

Publikováno v: The Lancet Neurology. 11:688-696

Summary Background Many people with epilepsy in low-income countries do not receive appropriate biomedical treatment. This epilepsy treatment gap might be caused by patients not seeking biomedical treatment or not adhering to prescribed antiepileptic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6ff5427fb2391c93d540dd242c9cb1
https://doi.org/10.1016/s1474-4422(12)70155-2

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Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation

Autor: Japhet Karisa, Wanchana Ungphakorn, Gilbert Kokwaro, Nahashon Thuo, Simon N. Muchohi, Kathryn Maitland, Alex Muturi, Alison H. Thomson

Publikováno v: Journal of Antimicrobial Chemotherapy

Background Severe malnutrition is frequently complicated by sepsis, leading to high case fatality. Oral ciprofloxacin is a potential alternative to the standard parenteral ampicillin/gentamicin combination, but its pharmacokinetics in malnourished ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adc0ee4d1a6694e05f0144f77daa339
https://doi.org/10.1093/jac/dkr314

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Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: Application to a population pharmacokinetics study in children with severe malnutrition

Autor: Gilbert Kokwaro, Alex Muturi, Nahashon Thuo, Simon N. Muchohi, Japhet Karisa, Kathryn Maitland

Publikováno v: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

Article published in Journal of Chromatography B Clinical pharmacokinetic studies of ciprofloxacin require accurate and precise measurement of plasma drug concentrations. We describe a rapid, selective and sensitive HPLC method coupled with fluoresce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753325899e8c10f6b83e8d86ac0d9cc9
http://hdl.handle.net/11071/3858

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Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection

Autor: Gilbert Kokwaro, Simon N. Muchohi, Bernhards Ogutu, Geoffrey Edwards, Isaiah M Githiga, Kenneth Obiero, Charles R. Newton

Publikováno v: Journal of Chromatography B. 824:333-340

A simple, sensitive, selective, and reproducible reversed-phase high-performance liquid chromatographic (HPLC) method with UV detection was developed for the determination of lorazepam (LZP) in human plasma, using oxazepam (OZP) as internal standard.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a261e6a36f58c5739f88f6f6c003f7b5
https://doi.org/10.1016/j.jchromb.2005.07.040

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Determination of midazolam and its major metabolite 1′-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children

Autor: Simon N. Muchohi, Gilbert Kokwaro, Charles R. Newton, Geoffrey Edwards, Louise Preston, Steve A. Ward

Publikováno v: Journal of Chromatography B. 821:1-7

We have developed a sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) for the simultaneous quantification of midazolam (MDZ) and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1659224aae377512b69c4a8e36f8dbf4
https://doi.org/10.1016/j.jchromb.2005.03.015

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Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper

Autor: Gilbert Kokwaro, Evelyn Gitau, Bernhards Ogutu, I M Githiga, Simon N. Muchohi

Publikováno v: Journal of Chromatography B. 799:173-177

We have developed a sensitive, selective and reproducible reversed-phase HPLC method with ultraviolet detection (340 nm) for the simultaneous quantification of amodiaquine (AQ) and its major metabolite, desethylamodiaquine (AQm) in a small volume (20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd2f944b5bec3a715efff8e9c4c0218
https://doi.org/10.1016/j.jchromb.2003.10.006

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Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria

Autor: William M. Watkins, Sadik Mithwani, Simon N. Muchohi, Geoffrey Edwards, Gilbert Kokwaro, Kevin Marsh, Sumia Sir-Elkhatim Mohamed, Leon Aarons, Oneeb Majid

Publikováno v: British Journal of Clinical Pharmacology. 57:146-152

Aims To determine the population pharmacokinetics of artemether and dihydroartemisinin in African children with severe malaria and acidosis associated with respiratory distress following an intramuscular injection of artemether. Methods Following a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc9aa266351a6d4ca46fced19d430441
https://doi.org/10.1046/j.1365-2125.2003.01986.x

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