Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simon Moshiach"'
Autor:
Wei M Liu, Feng Zhang, Simon Moshiach, Bin Zhou, Chao Huang, Kamalakkannan Srinivasan, Seema Khurana, Yi Zheng, Jill M Lahti, Xin A Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51797 (2012)
To determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we assessed which cellular events critical for motility are altered by KAI1/CD82 and how KAI1/CD82 regulates these events. We found that KAI1/CD82-express
Externí odkaz:
https://doaj.org/article/3bebad17cb8642a096a9e3ffe11a1129
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16783 (2011)
Genome reduction is a hallmark of obligate intracellular pathogens such as Chlamydia, where adaptation to intracellular growth has resulted in the elimination of genes encoding biosynthetic enzymes. Accordingly, chlamydiae rely heavily on the host ce
Externí odkaz:
https://doaj.org/article/41e40317d6144fc996f1e6a893407997
Autor:
Yvan Campos, Xiaohui Qiu, Edmar Zanoteli, Simon Moshiach, Naja Vergani, Antonella Bongiovanni, A John Harris, Alessandra d'Azzo
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9866 (2010)
Muscle contractile proteins are expressed as a series of developmental isoforms that are in constant dynamic remodeling during embryogenesis, but how obsolete molecules are recognized and removed is not known. Ozz is a developmentally regulated prote
Externí odkaz:
https://doaj.org/article/819429bbe6fa40818af3ea631a21a59b
Autor:
Hua-Rong Shao, Stephan W. Morris, Jyh-Rong Chao, Amina Fu, Yi Sun, Wu Xu, Guo-yan Qi, Kelli L. Boyd, Alan Pourpak, Simon Moshiach, Stanley Pounds
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(4)
In the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial protein complex, anti-apoptotic signals are generated by cleavage and activation of the serine protease HtrA2/OMI by the rhomboid protease PARL upon recruitment of both proteases to inner mitochondrial m
Autor:
Rosario Mosca, David Finkelstein, Alessandra d'Azzo, Ida Annunziata, Xiaohui Qiu, Elida Gomero, Simon Moshiach, Christopher L. Morton, Yvan Campos, Shai White-Gilbertson, Diantha van de Vlekkert, Eda Machado, Laura J. Janke
Publikováno v:
Science Advances
LAMP1 oversialylation results in excessive lysosomal exocytosis, promoting tumor invasion and drug resistance.
Understanding how tumor cells transition to an invasive and drug-resistant phenotype is central to cancer biology, but the mechanisms
Understanding how tumor cells transition to an invasive and drug-resistant phenotype is central to cancer biology, but the mechanisms
Autor:
Norman Sachs, Hayden Huang, Jarett Michaelson, Yao Sun, Feng Zhang, Xin Zhang, Wenyuan Zhao, Jill M. Lahti, Arnoud Sonnenberg, Simon Moshiach
Publikováno v:
Blood. 118:4274-4284
Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathologic angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. Here we report tha
Autor:
Simon Moshiach, John Satumba, Brian Bothner, Sivashankar G. Sivakolundu, Chimere Ashley, Amanda Nourse, Jill M. Lahti, Richard W. Kriwacki
Publikováno v:
Journal of Molecular Biology. 384:240-254
Arf, Hdm2 and p53 regulate the tumor suppressor pathway that is most frequently disrupted in human cancer. In the absence of tumorigenic stress, Hdm2 actively attenuates p53-dependent cell cycle arrest and apoptosis by mediating ubiquitination-depend
Autor:
Huimin Hu, Erik J. Bonten, Samuel Connell, Gouri Yogalingam, Alessandra d'Azzo, Simon Moshiach, Diantha van de Vlekkert
Publikováno v:
Developmental Cell. 15(1):74-86
SummaryLysosomal exocytosis is a Ca2+-regulated mechanism that involves proteins responsible for cytoskeletal attachment and fusion of lysosomes with the plasma membrane. However, whether luminal lysosomal enzymes contribute to this process remains u
Autor:
Xin Zhang, Congfeng Xu, Jill M. Lahti, Qiusha Guo, Bing Xia, Yongde Jiang, Simon Moshiach, Yao Sun, Yuanjian Chen
Publikováno v:
European Journal of Cell Biology. 87:251-266
Although epithelial morphogenesis is tightly controlled by intrinsic genetic programs, the microenvironment in which epithelial cells proliferate and differentiate also contributes to the morphogenetic process. The roles of the physical microenvironm
Autor:
Samuel Connell, Douglas R. Green, Sebo Withoff, Christopher P. Dillon, Simon Moshiach, John L. Cleveland, Miguel A. Sanjuan, Frank C. Dorsey, Keiji Tanaka, Stephen W.G. Tait, Masaaki Komatsu
Publikováno v:
Nature. 450:1253-1257
Phagocytosis and autophagy are two ancient, highly conserved processes involved, respectively, in the removal of extracellular organisms and the destruction of organisms in the cytosol. Autophagy, for either metabolic regulation or defence, involves