Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia

Autor: Martin Stanulla, Martin Zimmermann, Melchior Lauten, Holger J. Schünemann, Paul G. Schlegel, Anja Möricke, Simon Modlich, Svitlana Igel, Sabine Illsinger, Georg C. Schwabe, Peter Schütte, Martin Schrappe, Gudrun Fleischhack, Matthias Schwab, Claudia Rossig, Laura Hinze, Gunnar Cario, Kjeld Schmiegelow, Elke Schaeffeler, Swantje Buchmann, Christian P. Kratz, Christian Flotho, Hans Hartmann, Stefanie V. Junk, Astrid Gnekow, Axel Sauerbrey, R Kolb

Publikováno v: Leukemia
Stanulla, M, Schaeffeler, E, Möricke, A, Buchmann, S, Zimmermann, M, Igel, S, Schmiegelow, K, Flotho, C, Hartmann, H, Illsinger, S, Sauerbrey, A, Junk, S V, Schütte, P, Hinze, L, Lauten, M, Modlich, S, Kolb, R, Rossig, C, Schwabe, G, Gnekow, A K, Fleischhack, G, Schlegel, P G, Schünemann, H J, Kratz, C P, Cario, G, Schrappe, M & Schwab, M 2021, ' Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia ', Leukemia, vol. 35, no. 9, pp. 2650-2657 . https://doi.org/10.1038/s41375-021-01203-7

Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction syndrome (SOS). Nevertheless, current treatment continues to use short-term applications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2097cbe574d45d3e2858da69aa6eb187
https://pubmed.ncbi.nlm.nih.gov/33714975

Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): a retrospective survey

Autor: Klaus, Bienemann, Birgit, Burkhardt, Simon, Modlich, Ulrike, Meyer, Anja, Möricke, Kirsten, Bienemann, Christine, Mauz-Körholz, Gabriele, Escherich, Martin, Zimmermann, Dieter, Körholz, Gritta, Janka-Schaub, Martin, Schrappe, Alfred, Reiter, Arndt, Borkhardt

Publikováno v: British journal of haematology. 155(4)

Children with chromosomal instability syndromes have an increased risk of developing lymphoma and leukaemia. The treatment of these malignancies is hampered by therapy-associated toxicity and infectious complications. This retrospective analysis eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02bc32d85ab9b3c531178d380b9da238
https://pubmed.ncbi.nlm.nih.gov/21923652