Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Simon M. Schultze"'
New therapeutic approaches to counter the increasing prevalence of obesity and type 2 diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase (PI3K)/v-akt murine thymoma viral oncogene homologue (AKT), mitogen-activated pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03870163ac266be9273713d1dc8b5ba2
http://doc.rero.ch/record/290769/files/S1462399411002109.pdf
http://doc.rero.ch/record/290769/files/S1462399411002109.pdf
Autor:
Maren Dietrich, Andreas Geier, Brian A. Hemmings, Simon M. Schultze, Markus Niessen, Debby Hynx, Giatgen A. Spinas, Oliver Tschopp
Publikováno v:
Liver International. 35:1354-1366
Non-alcoholic fatty liver disease (NAFLD) is a major health problem and occurs frequently in the context of metabolic syndrome and type 2 diabetes mellitus. Hepatocyte-specific Pten-deficiency in mice was shown previously to result in hepatic steatos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b6e637745fe1cd8901cea877ce4cb3
https://doi.org/10.1111/liv.12600
https://doi.org/10.1111/liv.12600
Autor:
Oliver Tschopp, Monika Rau, Achim Weber, Simon M. Schultze, Beat Müllhaupt, Grace L. Guo, Bruno Stieger, Bo Kong, Andreas Geier, Johannes Schmitt
Publikováno v:
Liver International. 35:1133-1144
Background & Aims There is a growing evidence that bile acids are involved in the regulation of triglyceride-, cholesterol-homoeostasis and fat absorption. In this study organ-specific Fxr knockout mice were used to further investigate the influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7ccac59c8a43c0bcc690d30c5e354b
https://doi.org/10.1111/liv.12456
https://doi.org/10.1111/liv.12456
Autor:
Daniel Konrad, Thomas A. Lutz, J A Pospisilik, Stephan Wueest, L. Van Lommel, Simon M. Schultze, Julia M. Rytka, Sarah Debray, Daniel T. Meier, Frans Schuit, Katleen Lemaire, Helga Ellingsgaard, Simone Boller, O Tschopp, Sabine Rütti, U Malipiero, Jan A. Ehses, Marc Y. Donath, Peter Y. Wielinga, Harald Esterbauer, M. Böni-Schnetzler, Anica Schraenen
Publikováno v:
Diabetologia
Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the innate inflammatory response to numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1330d63e0f027ef7d009d6b89fffd004
Autor:
Jae Hwi Jang, Oliver Tschopp, Achim Weber, Andreas Rickenbacher, Christian E. Oberkofler, Bostjan Humar, Simon M. Schultze, Kuno Lehmann, Pierre-Alain Clavien, Rolf Graf, Christoph Tschuor, Dimitri A. Raptis
Publikováno v:
Gastroenterology
GASTROENTEROLOGY
GASTROENTEROLOGY
Background & Aims Extended liver resection leads to hepatic failure because of a small remnant liver volume. Excessive parenchymal damage has been proposed as the principal cause of this failure, but little is known about the contribution of a primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df7d0f797225277e5056319ed2b237d
https://www.zora.uzh.ch/id/eprint/66530/
https://www.zora.uzh.ch/id/eprint/66530/
Publikováno v:
Archives of physiology and biochemistry. 117(2)
The protein kinase B (PKB) family encompasses three isoforms; PKBα (AKT1), PKBβ (AKT2) and PKBγ (AKT3). PKBα and PKBβ but not PKBγ, are prominently expressed in classical insulin-sensitive tissues like liver, muscle and fat. Transgenic mice def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6facb160be981a2b88a0d3db3c040a91
https://pubmed.ncbi.nlm.nih.gov/21214427
https://pubmed.ncbi.nlm.nih.gov/21214427