Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Simon M. G. Braun"'
Autor:
Meropi Bagka, Hyeonyi Choi, Margaux Héritier, Hanna Schwaemmle, Quentin T. L. Pasquer, Simon M. G. Braun, Leonardo Scapozza, Yibo Wu, Sascha Hoogendoorn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in heal
Externí odkaz:
https://doaj.org/article/b4d2bb81f1b045a88f120d6c8ceeb87e
Autor:
Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Simon M. G. Braun, Nicole Francis, Rabih Murr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distin
Externí odkaz:
https://doaj.org/article/c700bba4738648ac97b97852cfa493cc
Autor:
Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
Externí odkaz:
https://doaj.org/article/6643f55537234e79b58f4c93aa3e4891
Autor:
Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing
Externí odkaz:
https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
Autor:
Antonina Hafner, Gerald R. Crabtree, Christopher M. Weber, Jacob G. Kirkland, Benjamin Z. Stanton, Alistair N. Boettiger, Simon M. G. Braun
Publikováno v:
Nature Structural & Molecular Biology, Vol. 28, No 6 (2021) pp. 501-511
Nat Struct Mol Biol
Nat Struct Mol Biol
The mammalian SWI/SNF complex, or BAF complex, has a conserved and direct role in antagonizing Polycomb-mediated repression. Yet, BAF also promotes repression by Polycomb in stem cells and cancer. How BAF both antagonizes and promotes Polycomb-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d553f63fe89284877c325a5813a60c66
https://archive-ouverte.unige.ch/unige:154515
https://archive-ouverte.unige.ch/unige:154515
Autor:
Jiong Tang, Gerald R. Crabtree, Andrey Krokhotin, Erik L. Miller, Simon M. G. Braun, Georgia Panagiotakos, Ralitsa Petrova, Yitai Tang
Publikováno v:
Genes Dev
Genes and Development, Vol. 35, No 5-6 (2021) pp. 335-353
Genes and Development, Vol. 35, No 5-6 (2021) pp. 335-353
mSWI/SNF or BAF chromatin regulatory complexes are dosage-sensitive regulators of human neural development frequently mutated in autism spectrum disorders and intellectual disability. Cell cycle exit and differentiation of neural stem/progenitor cell
Autor:
Christopher M. Weber, Jacob G. Kirkland, Alistair N. Boettiger, Simon M. G. Braun, Antonina Hafner, Gerald R. Crabtree, Benjamin Z. Stanton
The mammalian SWI/SNF, or BAF complex, has a conserved and direct role in antagonizing polycomb-mediated repression. Yet, BAF appears to also promote repression by polycomb in stem cells and cancer. How BAF both antagonizes and promotes polycomb-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6fd1e607a213f67b87c830bce49e208
https://doi.org/10.1101/2020.01.29.925586
https://doi.org/10.1101/2020.01.29.925586
Autor:
Ralitsa Petrova, Andrey Krokhotin, Georgia Panagiotakos, Erik L. Miller, Yitai Tang, Gerald R. Crabtree, Jiong Tang, Simon M. G. Braun
Nervous system development is orchestrated by tightly-regulated progenitor cell divisions, followed by differentiation at precise but varying times across different regions. As progenitors exit the cell cycle, they initiate a subunit switch of the mS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617804892355fa86eba442f46204a21f
Autor:
Nathaniel A. Hathaway, Yafeng He, Gerald R. Crabtree, Kathrin Muegge, Simon M. G. Braun, Richard Finney, Jianke Ren, Kai Ni, Xiaoping Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol. 11, No 1 (2020) P. 5647
Nature Communications
Nature Communications, Vol. 11, No 1 (2020) P. 5647
The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4732fd1268110817593e7cbec47d2015
Autor:
Simon M. G. Braun, Raquel A.C. Machado, Jonathan Moss, Sebastian Jessberger, Burkhard Becher, Nicolas Toni, Gregor-Alexander Pilz
Publikováno v:
Cell Reports, 11 (11)
Cell Reports, Vol 11, Iss 11, Pp 1679-1685 (2015)
Cell reports
Cell Reports, vol. 11, no. 11, pp. 1679-1685
Cell Reports, Vol. 11, No 11 (2015) pp. 1679-1685
Cell Reports, Vol 11, Iss 11, Pp 1679-1685 (2015)
Cell reports
Cell Reports, vol. 11, no. 11, pp. 1679-1685
Cell Reports, Vol. 11, No 11 (2015) pp. 1679-1685
Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulatio