High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

Autor: Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Simon M. G. Braun, Nicole Francis, Rabih Murr

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distin

Externí odkaz: https://doaj.org/article/c700bba4738648ac97b97852cfa493cc

Rapid and reversible epigenome editing by endogenous chromatin regulators

Autor: Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing

Externí odkaz: https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893

BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex

Autor: Jiong Tang, Gerald R. Crabtree, Andrey Krokhotin, Erik L. Miller, Simon M. G. Braun, Georgia Panagiotakos, Ralitsa Petrova, Yitai Tang

Publikováno v: Genes Dev
Genes and Development, Vol. 35, No 5-6 (2021) pp. 335-353

mSWI/SNF or BAF chromatin regulatory complexes are dosage-sensitive regulators of human neural development frequently mutated in autism spectrum disorders and intellectual disability. Cell cycle exit and differentiation of neural stem/progenitor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbd43ee4c89faf44ef12c15e785b571
https://pubmed.ncbi.nlm.nih.gov/33602870

The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex

Autor: Ralitsa Petrova, Andrey Krokhotin, Georgia Panagiotakos, Erik L. Miller, Yitai Tang, Gerald R. Crabtree, Jiong Tang, Simon M. G. Braun

Nervous system development is orchestrated by tightly-regulated progenitor cell divisions, followed by differentiation at precise but varying times across different regions. As progenitors exit the cell cycle, they initiate a subunit switch of the mS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617804892355fa86eba442f46204a21f

Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury

Autor: Simon M. G. Braun, Raquel A.C. Machado, Jonathan Moss, Sebastian Jessberger, Burkhard Becher, Nicolas Toni, Gregor-Alexander Pilz

Publikováno v: Cell Reports, 11 (11)
Cell Reports, Vol 11, Iss 11, Pp 1679-1685 (2015)
Cell reports
Cell Reports, vol. 11, no. 11, pp. 1679-1685
Cell Reports, Vol. 11, No 11 (2015) pp. 1679-1685

Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b98d7135f6fdea57f72b97d9fa37b5a
https://doi.org/10.1016/j.celrep.2015.05.024