Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simon M. Brandl"'
Autor:
Nadine M. Woessner, Simon M. Brandl, Sara Hartmann, Wolfgang W. Schamel, Frederike A. Hartl, Susana Minguet
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAntigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 complex, and thereby to T cell activation. The CD3ε subunit plays a unique role i
Externí odkaz:
https://doaj.org/article/0a1412bd5d8541f29df79e6652127bbd
Autor:
Anh Thu Dang, Juliane Strietz, Alessandro Zenobi, Hanif J. Khameneh, Simon M. Brandl, Laura Lozza, Gregor Conradt, Stefan H.E. Kaufmann, Walter Reith, Ivo Kwee, Susana Minguet, Sonia T. Chelbi, Greta Guarda
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101900- (2021)
Summary: BTN3A molecules—BTN3A1 in particular—emerged as important mediators of Vγ9Vδ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular me
Externí odkaz:
https://doaj.org/article/de729f8b994f4debb0363e2537507785
Autor:
O Sascha Yousefi, Matthias Günther, Maximilian Hörner, Julia Chalupsky, Maximilian Wess, Simon M Brandl, Robert W Smith, Christian Fleck, Tim Kunkel, Matias D Zurbriggen, Thomas Höfer, Wilfried Weber, Wolfgang WA Schamel
Publikováno v:
eLife, Vol 8 (2019)
The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR). It is challe
Externí odkaz:
https://doaj.org/article/9cd03ee763d646c6a2e9196e850a27f3
Optogenetics is the genetic approach for controlling cellular processes with light. It provides spatiotemporal, quantitative and reversible control over biological signaling and metabolic processes, overcoming limitations of chemically inducible syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::656f5e51d684983c6141dc6f3a8925c3
https://zenodo.org/record/7638956
https://zenodo.org/record/7638956
Autor:
Kristian Schweimer, Sanaz Taromi, Julia Zimmermann, Maja Köhn, Frederike A. Hartl, Simon M. Brandl, Lea J. Flachsmann, Susana Minguet, Nico Hoefflin, Birgitta M. Wöhrl, Nadine M. Woessner, Anna Morath, Stefan Günther, Robert Zeiser, O. Sascha Yousefi, Pankaj Mishra, Gina J. Fiala, Esmeralda Beck-Garcia, Rubí M.-H. Velasco Cárdenas, Wolfgang W. A. Schamel
Publikováno v:
Nature Immunology
Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate signaling is not well known. We report a previously unknown binding motif
Autor:
Stefan Günther, Kristian Schweimer, Nadine M. Woessner, Nico Hoefflin, Rubí M.-H. Velasco Cárdenas, Anna Morath, Sanaz Taromi, Lea J. Flachsmann, Robert Zeiser, Pankaj Mishra, Julia Zimmermann, Simon M. Brandl, Frederike A. Hartl, Maja Köhn, Susana Minguet, Gina J. Fiala, Birgitta M. Wöhrl, O. Sascha Yousefi, Esmeralda Beck-Garcia, Wolfgang W. A. Schamel
Publikováno v:
Nature Immunology. 22:100-101
Autor:
Wilfried Weber, Rocio Ochoa-Fernandez, Thomas Ott, Rüdiger Simon, Giovanni Giuriani, Leonie-Alexa Koch, Franz-Georg Wieland, Jens Timmer, Simon M. Brandl, Nikolaj B. Abel, Jenia Schlegel, Raphael Engesser, J. Benjamin Miller, Matias D. Zurbriggen
Publikováno v:
Nature methods. 17(7)
Optogenetics is the genetic approach for controlling cellular processes with light. It provides spatiotemporal, quantitative and reversible control over biological signaling and metabolic processes, overcoming limitations of chemically inducible syst
Autor:
Julia Chalupsky, Christian Fleck, Matias D. Zurbriggen, O. Sascha Yousefi, Robert W. Smith, Tim Kunkel, Maximilian Wess, Wilfried Weber, Wolfgang W. A. Schamel, Matthias Günther, Thomas Höfer, Simon M. Brandl, Maximilian Hörner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b7127b8e7ae5be7e9c7651bba84b14
https://doi.org/10.7554/elife.42475.064
https://doi.org/10.7554/elife.42475.064
Autor:
Christian Fleck, Maximilian Wess, Omid Sascha Yousefi, Matias D. Zurbriggen, Matthias Günther, Tim Kunkel, Maximilian Hörner, Wilfried Weber, Simon M. Brandl, Thomas Höfer, Julia Chalupsky, Wolfgang W. A. Schamel, Robert W. Smith
Publikováno v:
eLife, 8
eLife
eLife, Vol 8 (2019)
eLife 8 (2019)
eLife
eLife, Vol 8 (2019)
eLife 8 (2019)
The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR). It is challe
Autor:
Rocio, Ochoa-Fernandez, Sophia L, Samodelov, Simon M, Brandl, Elke, Wehinger, Konrad, Müller, Wilfried, Weber, Matias D, Zurbriggen
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1408
Optogenetic tools to control gene expression have many advantages over the classical chemically inducible systems, overcoming intrinsic limitations of chemical inducers such as solubility, diffusion, and cell toxicity. They offer an unmatched spatiot