Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Simon M N Efange"'
Autor:
Fidele Ntie-Kang, Denis Zofou, Smith B Babiaka, Rolande Meudom, Michael Scharfe, Lydia L Lifongo, James A Mbah, Luc Meva'a Mbaze, Wolfgang Sippl, Simon M N Efange
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78085 (2013)
Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We assess the bioactivity and "drug-likeness" of a relatively small but structurall
Externí odkaz:
https://doaj.org/article/85357b95def44bc49e698dff96a524f4
Autor:
Maloba M. M. Lobe, Simon M. N. Efange
Publikováno v:
Royal Society Open Science, Vol 7, Iss 1 (2020)
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dih
Externí odkaz:
https://doaj.org/article/085cc046dde049edb57b95019718cf49
Autor:
Moses N. Ngemenya, Grace Ntube Abwenzoh, Hermia Nalova Ikome, Denis Zofou, Fidele Ntie-Kang, Simon M. N. Efange
Publikováno v:
BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-disubstituted piperid
Externí odkaz:
https://doaj.org/article/9a809e0d659b4c7e864ebec8443e83c9
Publikováno v:
Natural Products and Bioprospecting, Vol 7, Iss 3, Pp 235-247 (2017)
Abstract The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1–6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is re
Externí odkaz:
https://doaj.org/article/ce3fcbe6464f41ac9679f0801be5e486
Autor:
Noella M. Efange, Maloba M. M. Lobe, Lauve R. T. Yamthe, Jeannette N. M. Pekam, Protus A. Tarkang, Lawrence Ayong, Simon M. N. Efange
Publikováno v:
Antimicrob Agents Chemother
Previous studies suggest that 3′,5′-dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones (DSIIQs [spiroquindolones]) are multitarget antiplasmodial agents that combine the actions of spiroindolone and naphthylisoquinoline antimalarial agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8060decb91a0ceab5cd8f517d652f9
https://pubmed.ncbi.nlm.nih.gov/36409128
https://pubmed.ncbi.nlm.nih.gov/36409128
Autor:
Cyril T. Namba-Nzanguim, Gemma Turon, Conrad V. Simoben, Ian Tietjen, Luis J. Montaner, Simon M. N. Efange, Miquel Duran-Frigola, Fidele Ntie-Kang
Publikováno v:
Frontiers in Drug Discovery. 2
Current antiviral drug discovery efforts face many challenges, including development of new drugs during an outbreak and coping with drug resistance due to rapidly accumulating viral mutations. Emerging artificial intelligence and machine learning (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2dd1c437550c85f1b6779f6d10ea4cc
https://doi.org/10.3389/fddsv.2022.1013285
https://doi.org/10.3389/fddsv.2022.1013285
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Molecular hybridization of privileged scaffolds may generate novel antiplasmodial chemotypes that display superior biological activity and delay drug resistance. In the present study, we describe the in vitro activities and mode of action of 3′,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7cd524f5072cc944343bf76191f70d
https://doi.org/10.1038/s41598-020-74824-0
https://doi.org/10.1038/s41598-020-74824-0
Publikováno v:
Natural Products and Bioprospecting, Vol 7, Iss 3, Pp 235-247 (2017)
Natural Products and Bioprospecting
Natural Products and Bioprospecting
The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1–6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is reported. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56252a51f4d12954214e6d6ee6563b1
http://link.springer.com/article/10.1007/s13659-017-0125-y
http://link.springer.com/article/10.1007/s13659-017-0125-y
Autor:
Grace Ntube Abwenzoh, Hermia Nalova Ikome, Simon M. N. Efange, Denis Zofou, Moses N. Ngemenya, Fidele Ntie-Kang
Publikováno v:
BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-7 (2018)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-disubstituted piperidines with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4e34401d0552e14d6fad46a6bc60cf
https://doi.org/10.1186/s40360-018-0233-2
https://doi.org/10.1186/s40360-018-0233-2
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 6, Pp 472-477 (2015)
Objective To evaluate the antibacterial activity of ten synthetic tetrahydroisoquinolines against eight bacterial strains. Methods The ten tetrahydroisoquinolines synthesized via base-catalyzed Pictet–Spengler cyclization were screened against a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654e320e8731ed4a5acd184c1d858647