Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Simon M Lichtinger"'
Publikováno v:
eLife, Vol 13 (2024)
Proton-coupled oligopeptide transporters (POTs) are of great pharmaceutical interest owing to their promiscuous substrate binding site that has been linked to improved oral bioavailability of several classes of drugs. Members of the POT family are co
Externí odkaz:
https://doaj.org/article/a81effb883ee4d87878995426199639c
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009328 (2021)
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which protein features are impor
Externí odkaz:
https://doaj.org/article/8451791b5c80476b8177c2c6cc4e33b7
Publikováno v:
Plos Computational Biology
bioRxiv
PLoS Computational Biology, Vol 17, Iss 8, p e1009328 (2021)
PLoS Computational Biology
bioRxiv
PLoS Computational Biology, Vol 17, Iss 8, p e1009328 (2021)
PLoS Computational Biology
Funder: Science and Technology Facilities Council; funder-id: http://dx.doi.org/10.13039/501100000271
Funder: Winton Programme for the Physics of Sustainability
Funder: German Academic Scholarship Foundation
Rationally and efficiently
Funder: Winton Programme for the Physics of Sustainability
Funder: German Academic Scholarship Foundation
Rationally and efficiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83869e4295fe729d0ed95d227358adb
Autor:
Joanne L. Parker, Justin C. Deme, Simon M. Lichtinger, Gabriel Kuteyi, Philip C. Biggin, Susan M. Lea, Simon Newstead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The uptake and elimination of beta-lactam antibiotics in the human body are facilitated by the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). The mechanism by which SLC15 family transporters recognize and discrimina
Externí odkaz:
https://doaj.org/article/66b1ac35c95b49cdb878067a8315deb4