Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Simon M Cool"'
Autor:
Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/174408689eff4e6e9ca900272ba6e6a0
Autor:
Rachel K Okolicsanyi, Emily T Camilleri, Lotta E Oikari, Chieh Yu, Simon M Cool, Andre J van Wijnen, Lyn R Griffiths, Larisa M Haupt
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137255 (2015)
The suitability of human mesenchymal stem cells (hMSCs) in regenerative medicine relies on retention of their proliferative expansion potential in conjunction with the ability to differentiate toward multiple lineages. Successful utilisation of these
Externí odkaz:
https://doaj.org/article/b8c0fec0a54941ecb7c57a63e61e99b7
Autor:
Marta Kisiel, Agnieszka S Klar, Manuela Ventura, Jos Buijs, Marc-Krystelle Mafina, Simon M Cool, Jöns Hilborn
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78551 (2013)
Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of skeletal non-union and spinal fusion. However, BMP-2 delivery in a conventional collagen scaffold necessitates a high dose to achieve an efficacious outcome.
Externí odkaz:
https://doaj.org/article/38ea273698694e2f827c90c59cdefbc5
Autor:
Tong Ming Liu, Ege Deniz Yildirim, Pin Li, Hai Tong Fang, Vinitha Denslin, Vibhor Kumar, Yuin Han Loh, Eng Hin Lee, Simon M. Cool, Bin Tean Teh, James H. Hui, Bing Lim, Ng Shyh-Chang
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 210-225 (2020)
Summary: The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate incr
Externí odkaz:
https://doaj.org/article/4d9d3e38c78343fd95dc58634ee62cac
Autor:
Ling Ling, Xiafei Ren, Xue Cao, Afizah Binte Mohd Hassan, Sophia Mah, Padmapriya Sathiyanathan, Raymond A.A. Smith, Clarissa L.L. Tan, Michelle Eio, Rebekah M. Samsonraj, Andre J. van Wijnen, Michael Raghunath, Victor Nurcombe, James H. Hui, Simon M. Cool
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 105-121 (2020)
Summary: Human mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in media frequently supplemented with fibroblast growth factor 2 (FGF2). Particular hep
Externí odkaz:
https://doaj.org/article/20588c373c4b42dcb4070cc8ac8229d2
Autor:
Jamie Trott, Ee Kim Tan, Sheena Ong, Drew M. Titmarsh, Simon L.I.J. Denil, Maybelline Giam, Cheng Kit Wong, Jiaxu Wang, Mohammad Shboul, Michelle Eio, Justin Cooper-White, Simon M. Cool, Giulia Rancati, Lawrence W. Stanton, Bruno Reversade, N. Ray Dunn
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1675-1688 (2017)
Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable v
Externí odkaz:
https://doaj.org/article/420b4b50331549cead36ed5ee5db165a
Autor:
Nicholas Tan Kwan Zen, Kerwin Zeming Kwek, Teo Kim Leng, Mavis Loberas, Jialing Lee, Chin Ren Goh, Da Hou Yang, Steve Oh, James Hui Hoi Po, Simon M. Cool, Han Wei Hou, Jongyoon Han
The growing interest in regenerative medicine has opened new avenues for novel cell therapies using stem cells. Bone Marrow Aspirate (BMA) is an important source of stromal mesenchymal stem cells (MSCs). Conventional MSC harvesting from BMA relies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296d69f72fe6086729138b1c0e145055
https://doi.org/10.1101/2023.05.03.539013
https://doi.org/10.1101/2023.05.03.539013
Autor:
Shih Yin Tsai, Chloe Xiaoyun Chan, Elisa Marie Crombie, Tuan Chun Tan, Simon M. Cool, Wen-Hai Zhuo, Wing Moon Raymond Lam, Hwee Weng Dennis Hey, Way Cherng Chen
Publikováno v:
The Spine Journal. 22:483-494
BACKGROUND Increasing kyphosis of the spine in a human is a well-recognized clinical phenomenon that has been associated with back pain, poor physical performance and disability. The pathophysiology of age-related kyphosis is complex and has been ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb1a91d7c894d2672abe2efc73dec0
https://doi.org/10.1016/j.spinee.2021.09.003
https://doi.org/10.1016/j.spinee.2021.09.003
Autor:
James C.H. Goh, Soo Yein Toh, Sunny Akogwu Abbah, Simon M. Cool, Ming Wang, Hee-Kit Wong, Jun Li, Amit K. Ramruttun, Kishore Bhakoo, Ling Liu, Tao Hu, Raymond W. Lam
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 16:63-75
High doses BMP-2 have resulted in a series of complications in spinal fusion. We previously established a polyelectrolyte complex (PEC) carrier system that reduces the therapeutic dose of BMP-2 in both rodent and porcine spinal fusion models. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c6c2ea49d4187134d75e1346e972ee
https://doi.org/10.1002/term.3260
https://doi.org/10.1002/term.3260
Publikováno v:
European Cells & Materials, Vol 42, Pp 139-153 (2021)
Periodontitis is the most common inflammatory disease that leads to periodontal defects and tooth loss. Regeneration of alveolar bone and soft tissue in periodontal defects is highly desirable but remains challenging. A heparan sulphate variant (HS3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fdd0723ac1ee7843063dbc07dd8842
https://www.ecmjournal.org/papers/vol042/pdf/v042a09.pdf
https://www.ecmjournal.org/papers/vol042/pdf/v042a09.pdf