Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Simon M, Poucher"'
Autor:
Hannah Lees, Jonathan Swann, Simon M Poucher, Jeremy K Nicholson, Elaine Holmes, Ian D Wilson, Julian R Marchesi
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e100916 (2014)
Animal models are invaluable tools which allow us to investigate the microbiome-host dialogue. However, experimental design introduces biases in the data that we collect, also potentially leading to biased conclusions. With obesity at pandemic levels
Externí odkaz:
https://doaj.org/article/644d55be95c84a4dafd6463d20a3a45e
Autor:
Despina Constantin, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Simon M. Poucher, Craig Porter, Brendan Leighton
Publikováno v:
The Journal of Physiology. 595:5765-5780
Key points Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, although the impact of meldonium-mediated muscle carnitine depletion on whole-body fuel selection, and muscle fuel metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::700dbf4d7b7b7627cedf3d83ef765b8f
https://doi.org/10.1113/jp274415
https://doi.org/10.1113/jp274415
Autor:
Anton J. M. Wagenmakers, Janice M. Marshall, Ruth Macdonald, Ann E. Griffin, Simon M. Poucher
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 86:67-75
INTRODUCTION: Accurate assessment of muscle insulin sensitivity requires measurement of insulin concentration in interstitial fluid (ISF), but has proved difficult. We aimed to optimise measurement of ISF insulin concentrations in rat muscles in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69e86be3d03f9de04561517d1d87268
https://doi.org/10.1016/j.vascn.2017.04.001
https://doi.org/10.1016/j.vascn.2017.04.001
Autor:
Simon M. Poucher, Hannah Lees, Ian D. Wilson, Elaine Holmes, Jeremy K. Nicholson, Jonathan R. Swann
Publikováno v:
Journal of proteome research. 18(5)
Obesity and its comorbidities are increasing worldwide imposing a heavy socioeconomic burden. The effects of obesity on the metabolic profiles of tissues (liver, kidney, pancreas), urine, and the systemic circulation were investigated in the Zucker r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc558dfad2645cda8f09d7c6aab5f191
https://pubmed.ncbi.nlm.nih.gov/30939873
https://pubmed.ncbi.nlm.nih.gov/30939873
Autor:
Craig, Porter, Dumitru, Constantin-Teodosiu, Despina, Constantin, Brendan, Leighton, Simon M, Poucher, Paul L, Greenhaff
Publikováno v:
The Journal of physiology. 595(17)
Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, although the impact of meldonium-mediated muscle carnitine depletion on whole-body fuel selection, and muscle fuel metabolism and its mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25e01ed9f21344b5c87430cf8274a2a5
https://pubmed.ncbi.nlm.nih.gov/28733980
https://pubmed.ncbi.nlm.nih.gov/28733980
Autor:
E Leverton, Simon M. Poucher, Peter G. Morris, J A Lockton, E. Y. H. Khoo, Jan W. Eriksson, Peter Mansell, Ian A. Macdonald, Mary C. Stephenson, Lars Johansson
Publikováno v:
NMR in Biomedicine. 26:1518-1526
The measurement of tissue lipid and glycogen contents and the establishment of normal levels of variability are important when assessing changes caused by pathology or treatment. We measured hepatic and skeletal muscle lipid and glycogen levels using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d80c2a65d6c9f4c193dd96a3e3bbec
https://doi.org/10.1002/nbm.2985
https://doi.org/10.1002/nbm.2985
Autor:
William N. Washburn, Simon M. Poucher
Publikováno v:
Expert Opinion on Investigational Drugs. 22:463-486
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a novel class of agents for the treatment of type 2 diabetes mellitus (T2DM). By inhibiting SGLT2, they prevent renal glucose reabsorption, resulting in glucosuria.The rationale for development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b780fe3c489be0af7f4c64e7f2fd6f79
https://doi.org/10.1517/13543784.2013.774372
https://doi.org/10.1517/13543784.2013.774372
Publikováno v:
Diabetes, Obesity and Metabolism. 14:918-926
Aims We examined the effects of the oral dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin on glycaemic control and pancreatic β-cell mass and morphology in a mouse model of type 2 diabetes mellitus (T2DM). Methods Male C57BL/6 mice (n = 12/group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97ec63fbec7116f98e18813f7ffc260
https://doi.org/10.1111/j.1463-1326.2012.01619.x
https://doi.org/10.1111/j.1463-1326.2012.01619.x
Autor:
Victor P Bilan, Simon M. Poucher, Eman M. Salah, Bradley Zinker, Rachel M. Mayers, Sheldon I. Bastacky, Stevan P. Tofovic, Huw B. Jones
Publikováno v:
Journal of Endocrinology. 210:293-308
Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Yet the pathogenic mechanisms underlying the development of DN are not fully defined, partially due to lack of suitable models that mimic the complex pathogenesis of renal disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221f22278238e69bb183811155880d23
https://doi.org/10.1530/joe-11-0122
https://doi.org/10.1530/joe-11-0122
Publikováno v:
Computer Methods and Programs in Biomedicine. 102:119-129
The glucose-insulin system is a challenging process to model due to the feedback mechanisms present, hence the implementation of a model-based approach to the system is an on-going and challenging research area. A new approach is proposed here which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad99c946643d65bb1756e72c3ba4acf
https://doi.org/10.1016/j.cmpb.2010.08.013
https://doi.org/10.1016/j.cmpb.2010.08.013