Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Simon M, Cool"'
Autor:
Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/174408689eff4e6e9ca900272ba6e6a0
Autor:
Xiaoman Luo, Chau Sang Lau, Bach Quang Le, Tuan Chun Tan, Jian Hui Too, Raymond Alexander Alfred Smith, Na Yu, Simon M. Cool
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract It is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration in a rodent m
Externí odkaz:
https://doaj.org/article/0cf7a89fd8db47a9b66a4c83dabf92fb
Autor:
Tong Ming Liu, Ege Deniz Yildirim, Pin Li, Hai Tong Fang, Vinitha Denslin, Vibhor Kumar, Yuin Han Loh, Eng Hin Lee, Simon M. Cool, Bin Tean Teh, James H. Hui, Bing Lim, Ng Shyh-Chang
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 210-225 (2020)
Summary: The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate incr
Externí odkaz:
https://doaj.org/article/4d9d3e38c78343fd95dc58634ee62cac
Autor:
Ling Ling, Xiafei Ren, Xue Cao, Afizah Binte Mohd Hassan, Sophia Mah, Padmapriya Sathiyanathan, Raymond A.A. Smith, Clarissa L.L. Tan, Michelle Eio, Rebekah M. Samsonraj, Andre J. van Wijnen, Michael Raghunath, Victor Nurcombe, James H. Hui, Simon M. Cool
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 105-121 (2020)
Summary: Human mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in media frequently supplemented with fibroblast growth factor 2 (FGF2). Particular hep
Externí odkaz:
https://doaj.org/article/20588c373c4b42dcb4070cc8ac8229d2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior an
Externí odkaz:
https://doaj.org/article/a331013a36744136a09ba5215857a010
Autor:
Nicholas Tan Kwan Zen, Kerwin Zeming Kwek, Teo Kim Leng, Mavis Loberas, Jialing Lee, Chin Ren Goh, Da Hou Yang, Steve Oh, James Hui Hoi Po, Simon M. Cool, Han Wei Hou, Jongyoon Han
The growing interest in regenerative medicine has opened new avenues for novel cell therapies using stem cells. Bone Marrow Aspirate (BMA) is an important source of stromal mesenchymal stem cells (MSCs). Conventional MSC harvesting from BMA relies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296d69f72fe6086729138b1c0e145055
https://doi.org/10.1101/2023.05.03.539013
https://doi.org/10.1101/2023.05.03.539013
Autor:
Jamie Trott, Ee Kim Tan, Sheena Ong, Drew M. Titmarsh, Simon L.I.J. Denil, Maybelline Giam, Cheng Kit Wong, Jiaxu Wang, Mohammad Shboul, Michelle Eio, Justin Cooper-White, Simon M. Cool, Giulia Rancati, Lawrence W. Stanton, Bruno Reversade, N. Ray Dunn
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1675-1688 (2017)
Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable v
Externí odkaz:
https://doaj.org/article/420b4b50331549cead36ed5ee5db165a
Autor:
Shih Yin Tsai, Chloe Xiaoyun Chan, Elisa Marie Crombie, Tuan Chun Tan, Simon M. Cool, Wen-Hai Zhuo, Wing Moon Raymond Lam, Hwee Weng Dennis Hey, Way Cherng Chen
Publikováno v:
The Spine Journal. 22:483-494
BACKGROUND Increasing kyphosis of the spine in a human is a well-recognized clinical phenomenon that has been associated with back pain, poor physical performance and disability. The pathophysiology of age-related kyphosis is complex and has been ass
Autor:
James C.H. Goh, Soo Yein Toh, Sunny Akogwu Abbah, Simon M. Cool, Ming Wang, Hee-Kit Wong, Jun Li, Amit K. Ramruttun, Kishore Bhakoo, Ling Liu, Tao Hu, Raymond W. Lam
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 16:63-75
High doses BMP-2 have resulted in a series of complications in spinal fusion. We previously established a polyelectrolyte complex (PEC) carrier system that reduces the therapeutic dose of BMP-2 in both rodent and porcine spinal fusion models. This st
Publikováno v:
European Cells & Materials, Vol 42, Pp 139-153 (2021)
Periodontitis is the most common inflammatory disease that leads to periodontal defects and tooth loss. Regeneration of alveolar bone and soft tissue in periodontal defects is highly desirable but remains challenging. A heparan sulphate variant (HS3)