An N-Allylglyoxylamide Based Bioorthogonal Nitrone Trap

Autor: Daniel Lee, Simon Latour, Michael Emblem, Jobette Santos, Jaewan Jang, Alison McGuigan, Mark Nitz

Aldehydes are attractive bioorthogonal coupling partners. The ease of manipulation of aldehydes and their orthogonality to other classes of bioorthogonal reactions has inspired the exploration of chemistries which generate irreversible conjugates. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d0529dda5ec0fb2a9b4650121f0ea87
https://doi.org/10.26434/chemrxiv-2022-bk73l-v2

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arrays

Autor: Ruonan Cao, Nancy T Li, Jose L Cadavid, Simon Latour, Cassidy M Tan, Alison P McGuigan

The success rate of bringing novel cancer therapies to the clinic remains extremely low due to the lack of relevant pre-clinical culture models that capture the complexity of human tumours. Patient-derived organoids have emerged as a useful tool to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e39f858641aca8fda616f5328ee91634
https://doi.org/10.1101/2022.08.20.504600

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

Autor: Nancy T. Li, Nila C. Wu, Ruonan Cao, Jose L. Cadavid, Simon Latour, Xiaoya Lu, Yutong Zhu, Mirjana Mijalkovic, Reza Roozitalab, Natalie Landon-Brace, Faiyaz Notta, Alison P. McGuigan

Publikováno v: Biomaterials. 291

Complex 3D bioengineered tumour models provide the opportunity to better capture the heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to study tumour heterogeneity and variation in patient responses. Organoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c345fab2f89ed68460923ca183994db
https://pubmed.ncbi.nlm.nih.gov/36343611

A novel 3D culture model recapitulates primary FL B cell features and promotes their survival

Autor: Valérie Le Morvan, Pierre Nassoy, Patricia Legoix, Céline Pangault, Simon Latour, Pierre Soubeyran, Laurence Bresson-Bepoldin, Frédéric Mourcin, Kevin Alessandri, Elise Dessauge, Martina Prochazkova-Carlotti, Julien Saint-Vanne, Lea Broca-Brisson, Nelson Hélaine, Karin Tarte, Jean-Philippe Merlio, Sylvain Baulande, Laurent Deleurme, Isabelle Mahouche, Laetitia Andrique, Céline Monvoisin, Gaëlle Recher, Christelle Dussert, Claire Lamaison, Marine Seffals

Publikováno v: Blood Advances
Blood Advances, 2021, ⟨10.1182/bloodadvances.2020003949⟩
Blood Advances, The American Society of Hematology, 2020, ⟨10.1182/bloodadvances.2020003949⟩
Blood Advances, The American Society of Hematology, 2021, ⟨10.1182/bloodadvances.2020003949⟩

Non-Hodgkin B-cell lymphomas (B-NHL) mainly develop within lymph nodes as aggregates of tumor cells densely packed with their surrounding microenvironment, creating a tumor niche specific to each lymphoma subtypes. In vitro preclinical models mimicki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf8445aa993a67d7ba9a527cc53b65f
https://hal.science/hal-03367891/document

Easy and robust micropatterning using fibrinogen anchors

Autor: Simon Latour, Alison P. McGuigan

Publikováno v: The Journal of Cell Biology

Watson et al. describe a general method to improve protein printing on glass (also known as micropatterning) while maintaining protein activity. In particular, this enables subcellular micropatterning, whereby complex micropatterns are able to simult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf8d8c201efef63faea79f0fc94defb
https://doi.org/10.1083/jcb.202012105