Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Simon Laban"'
Autor:
Tsima Abou Kors, Matthias Meier, Lena Mühlenbruch, Annika C. Betzler, Franziska Oliveri, Martin Bens, Jaya Thomas, Johann M. Kraus, Johannes Doescher, Adrian von Witzleben, Linda Hofmann, Jasmin Ezic, Diana Huber, Julian Benckendorff, Thomas F. E. Barth, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Jonathan M. Blackburn, Thomas K. Hoffmann, Christian Ottensmeier, Hans A. Kestler, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis antigens (CTA)
Externí odkaz:
https://doaj.org/article/395296b0c62b42a7af04bb14da175331
Autor:
Fabian Rosing, Matthias Meier, Lea Schroeder, Simon Laban, Thomas Hoffmann, Andreas Kaufmann, Oliver Siefer, Nora Wuerdemann, Jens Peter Klußmann, Thorsten Rieckmann, Yvonne Alt, Daniel L. Faden, Tim Waterboer, Daniela Höfler
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT The incidence rate of human papillomavirus-driven oropharyngeal cancer (HPV-OPC) is increasing in countries with high human development index. HPV cell-free DNA (cfDNA) isolated from 3 to 4 mL blood plasma has been successfully used for ther
Externí odkaz:
https://doaj.org/article/48533d1238d7461a9b378bb4cdffd83c
Autor:
Julius M. Vahl, Gabriele Nagel, Tsima Abou Kors, Matthias Brand, Adrian vonWitzleben, Michael Sonntag, Ayla Grages, Marie N. Theodoraki, Jens Greve, Michael Denkinger, Dhayana Dallmeier, Christian Idel, Stephan Stilgenbauer, Thomas K. Hoffmann, Simon Laban
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21426-21435 (2023)
Abstract Introduction Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in head and neck cancer (HNC) patients (HNCP) has not been performed previously. Methods
Externí odkaz:
https://doaj.org/article/403267fe0932404bb41475658f084ee6
Autor:
Markus Hecht, Benjamin Frey, Udo S. Gaipl, Xie Tianyu, Markus Eckstein, Anna-Jasmina Donaubauer, Gunther Klautke, Thomas Illmer, Maximilian Fleischmann, Simon Laban, Matthias G. Hautmann, Bálint Tamaskovics, Thomas B. Brunner, Ina Becker, Jian-Guo Zhou, Arndt Hartmann, Rainer Fietkau, Heinrich Iro, Michael Döllinger, Antoniu-Oreste Gostian, Andreas M. Kist
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 49, Iss , Pp 100953- (2024)
Purpose: Individual prediction of treatment response is crucial for personalized treatment in multimodal approaches against head-and-neck squamous cell carcinoma (HNSCC). So far, no reliable predictive parameters for treatment schemes containing immu
Externí odkaz:
https://doaj.org/article/545805f66b504b9d8a9522c916fbe3dc
Autor:
Julius M. Vahl, Gabriele Nagel, Ayla Grages, Matthias Brand, Adrian vonWitzleben, Michael Sonntag, Marie‐Nicole Theodoraki, Jens Greve, Tsima Aboukors, Michael Denkinger, Dhayana Dallmeier, Christian Idel, Thomas K. Hoffmann, Simon Laban
Publikováno v:
Cancer Medicine, Vol 12, Iss 18, Pp 18826-18836 (2023)
Abstract Background Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may affect head and neck cancer patients' (HNCP) outcomes. Here, we compare epidemiologica
Externí odkaz:
https://doaj.org/article/a1465fdd240b4ed1b704c84412fc0dbc
Autor:
Lisa T. Huber, Johann M. Kraus, Jasmin Ezić, Amin Wanli, Marco Groth, Simon Laban, Thomas K. Hoffmann, Barbara Wollenberg, Hans A. Kestler, Cornelia Brunner
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 3, Pp 422-446 (2023)
Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”. The present pilot study aims to investigate
Externí odkaz:
https://doaj.org/article/7f08bddc60874ffa92d65bc1ddf7441a
Autor:
Linda Hofmann, Marie Waizenegger, Ralph Röth, Stefanie Schmitteckert, Daphne Engelhardt, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundEpithelial to mesenchymal transition (EMT) is a key process in carcinogenesis of head and neck squamous cell carcinoma (HNSCC), contributing to tumor invasiveness, distant metastasis, and recurrence. Exosomes are known mediators and regulat
Externí odkaz:
https://doaj.org/article/da495342c7434169a99bd62712d7b29c
Autor:
Linda Hofmann, Tsima Abou Kors, Jasmin Ezić, Beate Niesler, Ralph Röth, Sonja Ludwig, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Valentin Medyany, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Head and neck squamous cell carcinomas (HNSCC) lack tumor-specific biomarkers. Exosomes from HNSCC patients carry immunomodulatory molecules, and correlate with clinical parameters. We compared miRNA profiles of plasma- and saliva-derived
Externí odkaz:
https://doaj.org/article/f4b07b257ef04856b71e8b242130684a
Autor:
Linda Hofmann, Valentin Medyany, Jasmin Ezić, Ramin Lotfi, Beate Niesler, Ralph Röth, Daphne Engelhardt, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Edwin K. Jackson, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundExosomes contribute to immunosuppression in head and neck squamous cell carcinoma (HNSCC), a tumor entity which lacks specific tumor biomarkers. Plasma-derived exosomes from HNSCC patients correlate with clinical parameters and have potenti
Externí odkaz:
https://doaj.org/article/b081436aafca40e187dd665805d0efb6
Autor:
Johannes Doescher, Adrian von Witzleben, Konstantinos Boukas, Stephanie E. Weissinger, Gareth J. Thomas, Simon Laban, Jaya Thomas, Thomas K. Hoffmann, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this therapy and require further treatment, either salvage surgery or palliative therapy. The addit
Externí odkaz:
https://doaj.org/article/0f6a2dfd86bf46f089d4d00e59c62b60