Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Simon Krautwald"'
Publikováno v:
Anti-fibrotic Drug Discovery ISBN: 9781788015103
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic, progressive, fibrotic scarring of the lung leading to decline in lung function and ultimately death. The median survival is three to five years and the numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::061f37a526960f7a1c5b3620058cdef0
https://doi.org/10.1039/9781788015783-00165
https://doi.org/10.1039/9781788015783-00165
Publikováno v:
Angewandte Chemie. International Edition, 56 (38)
An iridium-catalyzed cyclocondensation of amino alcohols and aldehydes is reported. Intramolecular allylic substitution by an enamine intermediate and subsequent in situ reduction furnishes 3,4-disubstituted piperidines with high enantiospecificity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1173a7fc9fd093f6b0fece2062532fca
https://doi.org/10.1002/anie.201706374
https://doi.org/10.1002/anie.201706374
Publikováno v:
Journal of the American Chemical Society
Experimental mechanistic studies of iridium-catalyzed, enantioselective allylic substitution enabled by (phosphoramidite,olefin) ligands are reported. (η2-Allylic alcohol)iridium(I) and (η3-allyl)iridium(III) complexes were synthesized and characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f3d9c54f015ffe79d7bb4b29de92c1
https://doi.org/10.1021/jacs.6b12421
https://doi.org/10.1021/jacs.6b12421
Publikováno v:
Organic letters. 21(21)
Enantioselective synthesis of a highly versatile building block en route to trachylobanes and related terpenoids is presented. The synthesis features diastereoselective Diels-Alder cycloaddition reaction, a cyclopropanation/homoquadricyclane rearrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd7cbef5caed5949e736d83c9ec1582
https://pubmed.ncbi.nlm.nih.gov/31603687
https://pubmed.ncbi.nlm.nih.gov/31603687
Publikováno v:
Journal of the American Chemical Society. 141(31)
The iridium-catalyzed asymmetric allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-butyl hydroperoxide, N-hydroxylamine, α-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057ede7571915f85e0403bf2d347bdbb
https://pubmed.ncbi.nlm.nih.gov/31318204
https://pubmed.ncbi.nlm.nih.gov/31318204
Autor:
Simon Krautwald, Michael Schneider, Erick M. Carreira, Marco Brandstätter, Matthieu J. R. Richter
Publikováno v:
Journal of the American Chemical Society. 143:9694-9694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ea88258d9b00c5d82466f60a781310
https://doi.org/10.1021/jacs.1c05408
https://doi.org/10.1021/jacs.1c05408
Autor:
Simon Krautwald, Mihoko Mori, Erick M. Carreira, Kazuro Shiomi, Satoshi Ōmura, Christian Nilewski
Publikováno v:
Angewandte Chemie. 128:4117-4121
Asymmetric synthesis and initial biological studies of two analogues of a naturally occurring chlorinated antifungal agent, atpenin A5, are described. These analogues were selected on the basis of Cl→CH3 or H3 C→Cl exchanges in the side-chain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b86e25eab89f8cb3d429ac0b17c4e7
https://doi.org/10.1002/ange.201511672
https://doi.org/10.1002/ange.201511672
Autor:
Simon Krautwald, Marco Brandstätter, Matthieu J. R. Richter, Michael Schneider, Erick M. Carreira
Publikováno v:
Journal of the American Chemical Society. 140(48)
The first synthesis of (−)-mitrephorone A is disclosed along with discussion and study of synthetic strategies. The natural product includes a highly congested hexacyclic ent-trachylobane diterpenoid framework featuring a rare, embedded oxetane. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65021c6bd8263d6cb290d903f73811d5
https://pubmed.ncbi.nlm.nih.gov/34156866
https://pubmed.ncbi.nlm.nih.gov/34156866
Publikováno v:
Angewandte Chemie. 127:14571-14575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4bba75116e92f134765cce637cd15a
https://doi.org/10.1002/ange.201506933
https://doi.org/10.1002/ange.201506933
Publikováno v:
Journal of the American Chemical Society. 139(10)
A cobalt-catalyzed method for the 1,1-diboration of terminal alkynes with bis(pinacolato)diboron (B2Pin2) is described. The reaction proceeds efficiently at 23 °C with excellent 1,1-selectivity and broad functional group tolerance. With the unsymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364919e8265baee859e630c071c9204c
https://pubmed.ncbi.nlm.nih.gov/28199104
https://pubmed.ncbi.nlm.nih.gov/28199104