Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Simon Koplev"'
Autor:
Zeyneb Kurt, Jenny Cheng, Rio Barrere-Cain, Caden N McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Wang, Johan Björkegren, Aldons J Lusis, Montgomery Blencowe, Xia Yang
Publikováno v:
eLife, Vol 12 (2023)
Mouse models have been used extensively to study human coronary artery disease (CAD) or atherosclerosis and to test therapeutic targets. However, whether mouse and human share similar genetic factors and pathogenic mechanisms of atherosclerosis has n
Externí odkaz:
https://doaj.org/article/e87fc1a00ff440dc9b28b69b90ccd82d
Autor:
Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O’Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L.M. Björkegren, Zhidong Tu, Carmen Argmann
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113371- (2023)
Summary: Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcripto
Externí odkaz:
https://doaj.org/article/1c20f6d542d54b86acc9526737df22b2
Autor:
Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucos
Externí odkaz:
https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
Autor:
Katherine C. Michelis, Aya Nomura-Kitabayashi, Laura Lecce, Oscar Franzén, Simon Koplev, Yang Xu, Maria Paola Santini, Valentina D'Escamard, Jonathan T.L. Lee, Valentin Fuster, Roger Hajjar, Ramachandra C. Reddy, Joanna Chikwe, Paul Stelzer, Farzan Filsoufi, Allan Stewart, Anelechi Anyanwu, Johan L.M. Björkegren, Jason C. Kovacic
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 242-257 (2018)
Summary: Mesenchymal stem cells (MSCs) reportedly exist in a vascular niche occupying the outer adventitial layer. However, these cells have not been well characterized in vivo in medium- and large-sized arteries in humans, and their potential pathol
Externí odkaz:
https://doaj.org/article/1f2349ca0d1348c4bbc264d6b3932a36
Autor:
Simon Koplev, James Longden, Jesper Ferkinghoff-Borg, Mathias Blicher Bjerregård, Thomas R. Cox, Janine T. Erler, Jesper T. Pedersen, Franziska Voellmy, Morten O.A. Sommer, Rune Linding
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2784-2791 (2017)
Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbatio
Externí odkaz:
https://doaj.org/article/262e116538d240979a729f07ca49550c
Autor:
Vivek Nanda, Ting Wang, Milos Pjanic, Boxiang Liu, Trieu Nguyen, Ljubica Perisic Matic, Ulf Hedin, Simon Koplev, Lijiang Ma, Oscar Franzén, Arno Ruusalepp, Eric E Schadt, Johan L M Björkegren, Stephen B Montgomery, Michael P Snyder, Thomas Quertermous, Nicholas J Leeper, Clint L Miller
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007755 (2018)
Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial wall-specific mechanisms. One of the annotated genes encodes LMOD1 (Leiomodin 1), a member of the ac
Externí odkaz:
https://doaj.org/article/c3959c46f0eb46e29d7c81bfaaf32757
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005911 (2018)
Integrating data from multiple regulatory layers across cancer types could elucidate additional mechanisms of oncogenesis. Using antibody-based protein profiling of 736 cancer cell lines, along with matching transcriptomic data, we show that pan-canc
Externí odkaz:
https://doaj.org/article/6108d3a83d2b4fa1ab5b0cfedaad9364
Autor:
Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Björkegren, Heribert Schunkert
Publikováno v:
Basic Research in Cardiology. 117
Autor:
Ke Hao, Raili Ermel, Katyayani Sukhavasi, Haoxiang Cheng, Lijiang Ma, Ling Li, Letizia Amadori, Simon Koplev, Oscar Franzén, Valentina d’Escamard, Nirupama Chandel, Kathryn Wolhuter, Nicole S. Bryce, Vamsidhar R.M. Venkata, Clint L. Miller, Arno Ruusalepp, Heribert Schunkert, Johan L.M. Björkegren, Jason C. Kovacic
Publikováno v:
Circ Genom Precis Med
Background: Hundreds of candidate genes have been associated with coronary artery disease (CAD) through genome-wide association studies. However, a systematic way to understand the causal mechanism(s) of these genes, and a means to prioritize them fo
Autor:
Simon Koplev, Marcus Seldin, Katyayani Sukhavasi, Raili Ermel, Shichao Pang, Lingyao Zeng, Sean Bankier, Antonio Di Narzo, Haoxiang Cheng, Vamsidhar Meda, Angela Ma, Husain Talukdar, Ariella Cohain, Letizia Amadori, Carmen Argmann, Sander M. Houten, Oscar Franzén, Giuseppe Mocci, Omar A. Meelu, Kiyotake Ishikawa, Carl Whatling, Anamika Jain, Rajeev Kumar Jain, Li-Ming Gan, Chiara Giannarelli, Panos Roussos, Ke Hao, Heribert Schunkert, Tom Michoel, Arno Ruusalepp, Eric E. Schadt, Jason C. Kovacic, Aldon J. Lusis, Johan L. M. Björkegren
Publikováno v:
Nat Cardiovasc Res
Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk factors, principally taking place in metabolic organs and the arterial wall. Here we show that 224 gene-regulatory coexpression networks (GRNs) identified by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a526ab2830c2578f0d53873d3cae4e
https://europepmc.org/articles/PMC9583458/
https://europepmc.org/articles/PMC9583458/