Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Simon Kasif"'
Autor:
Jonathan M. Dreyfuss, Yixing Yuchi, Xuehong Dong, Vissarion Efthymiou, Hui Pan, Donald C. Simonson, Ashley Vernon, Florencia Halperin, Pratik Aryal, Anish Konkar, Yinong Sebastian, Brandon W. Higgs, Joseph Grimsby, Cristina M. Rondinone, Simon Kasif, Barbara B. Kahn, Kathleen Foster, Randy Seeley, Allison Goldfine, Vera Djordjilović, Mary Elizabeth Patti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeo
Externí odkaz:
https://doaj.org/article/77b147ec15344c3cb4b79626a96517bd
Autor:
Daniel Lancour, Josée Dupuis, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard C. Schellenberg, Mark Crovella, Lindsay A. Farrer, Simon Kasif
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background Identifying and understanding the functional role of genetic risk factors for Alzheimer disease (AD) has been complicated by the variability of genetic influences across brain regions and confounding with age-related neurodegenera
Externí odkaz:
https://doaj.org/article/a030cad76a4049c59eb4f3bca41ab8df
Autor:
Alfred K. Ramirez, Simon N. Dankel, Bashir Rastegarpanah, Weikang Cai, Ruidan Xue, Mark Crovella, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The origin of the heterogeneity of metabolic and inflammatory profiles exhibited by white adipocytes is little understood. Here, using scRNA-seq and computational methods, the authors show that differentiating preadipocytes exhibit gene expression di
Externí odkaz:
https://doaj.org/article/1416263bed5c488e805d2dbdb75df926
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 21-36 (2019)
Objective: Accumulation of visceral white adipose tissue (WAT) associates with insulin resistance, adipose tissue inflammation, and metabolic syndrome, whereas accumulation of subcutaneous WAT may be protective. We aimed to identify molecular mechani
Externí odkaz:
https://doaj.org/article/ee3018b9e49243e5b317e1ed199718df
Autor:
Simon Kasif, Richard J Roberts
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000999 (2020)
How do we scale biological science to the demand of next generation biology and medicine to keep track of the facts, predictions, and hypotheses? These days, enormous amounts of DNA sequence and other omics data are generated. Since these data contai
Externí odkaz:
https://doaj.org/article/4ba3b1e37bb04bf8a6be513099dacf3b
Autor:
Alfred K. Ramirez, Matthew D. Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif, Jonathan M. Dreyfuss
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3040-3048 (2017)
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity. A common tool to assess metabolic differences between
Externí odkaz:
https://doaj.org/article/eae133fb784c475695891c7ed8339569
Autor:
Carles Lerin, Allison B. Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Jonathan M. Dreyfuss, Ana Luisa De Sousa-Coelho, Grace Daher, Irini Manoli, Justin R. Sysol, Elvira Isganaitis, Niels Jessen, Laurie J. Goodyear, Kirk Beebe, Walt Gall, Charles P. Venditti, Mary-Elizabeth Patti
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)
Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains u
Externí odkaz:
https://doaj.org/article/4be0d7d9bd0947dc91ff7cebd1442b54
Autor:
Daniel Lancour, Adam Naj, Richard Mayeux, Jonathan L Haines, Margaret A Pericak-Vance, Gerard D Schellenberg, Mark Crovella, Lindsay A Farrer, Simon Kasif
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007306 (2018)
Improving accuracy in genetic studies would greatly accelerate understanding the genetic basis of complex diseases. One approach to achieve such an improvement for risk variants identified by the genome wide association study (GWAS) approach is to in
Externí odkaz:
https://doaj.org/article/239ce9c373814543a12a06c57a98aee4
Autor:
Christopher Nogiec, Alison Burkart, Jonathan M. Dreyfuss, Carles Lerin, Simon Kasif, Mary-Elizabeth Patti
Publikováno v:
Molecular Metabolism, Vol 4, Iss 3, Pp 151-163 (2015)
Objective: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in
Externí odkaz:
https://doaj.org/article/7ee17466840843b7ae8cf2ccaf6ede51
Autor:
Esther Rheinbay, Mario L. Suvà, Shawn M. Gillespie, Hiroaki Wakimoto, Anoop P. Patel, Mohammad Shahid, Ozgur Oksuz, Samuel D. Rabkin, Robert L. Martuza, Miguel N. Rivera, David N. Louis, Simon Kasif, Andrew S. Chi, Bradley E. Bernstein
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1567-1579 (2013)
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we present a comparative analysis of chromatin state in GBM CSCs that r
Externí odkaz:
https://doaj.org/article/61ad20f8b8db4ae4a36b359023e2d865