Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Simon Karpatkin"'
The effect of thrombin on tumor cell cycle activation and spontaneous growth was examined in synchronized serum-starved tumor cell lines and a model of spontaneous prostate cancer development in TRAMP mice. BrdUrd incorporation and propidium iodide s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1da75a31cb7afaf33c02501ddc568de
https://doi.org/10.1158/0008-5472.c.6499473.v1
https://doi.org/10.1158/0008-5472.c.6499473.v1
Supplementary Figure 3 from Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a3fbf4e3bef78c976200a3f2df7ace
https://doi.org/10.1158/0008-5472.22380153
https://doi.org/10.1158/0008-5472.22380153
Supplementary Figure Legends 1-3 from Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb43794d9d89c7f65ae17390c7561a2
https://doi.org/10.1158/0008-5472.22380150
https://doi.org/10.1158/0008-5472.22380150
Supplementary Figure 1 from Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f5194311a3860266d2f30295c36fe1
https://doi.org/10.1158/0008-5472.22380159.v1
https://doi.org/10.1158/0008-5472.22380159.v1
Supplementary Figure 2 from Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e70679195ee27f4b922118e4a1c269f
https://doi.org/10.1158/0008-5472.22380156
https://doi.org/10.1158/0008-5472.22380156
Autor:
Suying Dang, Yong Ji, Jing Yang, Michael A. Nardi, Simon Karpatkin, Yong-Sheng Li, Thomas Wisniewski, Zongdong Li, Wei Zhang
Publikováno v:
Blood. 116:2336-2344
Patients with HIV-1 immune-related thrombocytopenia have a unique antibody (Ab) against integrin GPIIIa49-66 capable of inducing oxidative platelet fragmentation via Ab activation of platelet nicotinamide adenine dinucleotide phosphate oxidase and 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad4f7db00af0b858ecd7ccaab1ac903
https://doi.org/10.1182/blood-2010-01-264358
https://doi.org/10.1182/blood-2010-01-264358
Publikováno v:
International Journal of Cancer. 53:978-982
Thrombin has been shown to activate tumor-cell adhesion to platelets, fibronectin and von Willebrand factor 2- to 3-fold in vitro, and enhance metastasis 10- to 156-fold in vivo. We therefore elected to determine whether thrombin binds to tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b76228f0fc61dc70b9a6d6f7bdba9be
https://doi.org/10.1002/ijc.2910530620
https://doi.org/10.1002/ijc.2910530620
Publikováno v:
Cancer Research. 68:4666-4673
Cathepsin D (CD) up-regulation has been associated with human malignancy and poor prognosis. Thrombin up-regulated CD mRNA and protein in eight tumor cell lines as well as in human umbilical vascular endothelial cells (HUVEC). Thrombin increased the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e05450122bfb5df9f9fb2e954db26
https://doi.org/10.1158/0008-5472.can-07-6276
https://doi.org/10.1158/0008-5472.can-07-6276
Publikováno v:
Journal of Biological Chemistry. 283:3224-3230
We have described an autoantibody against beta3 (GPIIIa49-66), a region of platelet integrin alphaIIbbeta3 that is unique. It induces platelet fragmentation in the absence of complement via antibody activation of platelet NADPH oxidase and 12-lipoxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428e01939613a830995b7dc91d1c8f9f
https://doi.org/10.1074/jbc.m705902200
https://doi.org/10.1074/jbc.m705902200
Publikováno v:
Blood. 110:1989-1996
An HIV antibody (Ab) against platelet integrin GPIIIa49-66 induces complement-independent platelet particle formation by the elaboration of reactive oxygen species (ROS) downstream of the activation of the platelet NADPH oxidase by the 12-lipoxygenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7b96ebd8647b6b91f01181302af878
https://doi.org/10.1182/blood-2006-10-054064
https://doi.org/10.1182/blood-2006-10-054064