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of 3
pro vyhledávání: '"Simon Kaeppeli"'
Autor:
Anna M. Jermakowicz, Alison M. Kurimchak, Katherine J. Johnson, Florence Bourgain-Guglielmetti, Simon Kaeppeli, Maurizio Affer, Hari Pradhyumnan, Robert K. Suter, Winston Walters, Maria Cepero, James S. Duncan, Nagi G. Ayad
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized i
Externí odkaz:
https://doaj.org/article/4f50f991d1904053be9db08dafc453a4
Publikováno v:
Neuro-Oncology. 24:vii103-vii104
The treatment for glioblastoma (GBM) is maximal safe resection, temozolomide chemotherapy, and radiation therapy. However, with a median survival of only 15 months, new therapies are needed. GBM tumors are highly heterogeneous and three tumor subtype
Autor:
Robert Suter, Anna Jermakowicz, Vasileios Stathias, Luz Ruiz, Matthew D'Antuono, Simon Kaeppeli, Grace Baker, Rithvik Veeramachaneni, Winston Walters, Maria Cepero, Sion Williams, Michael Ivan, Ricardo Komotar, Macarena De La Fuente, Jann Sarkaria, Stephan Schürer, Nagi Ayad
Publikováno v:
Neuro-Oncology. 24:vii118-vii118
Glioblastoma (GBM) remains the most common and lethal adult primary brain cancer. Two of the most significant issues preventing the development of effective GBM treatments are inter- and intra-tumor heterogeneity. To address these issues, we develope