The chromodomain proteins, Cbx1 and Cbx2 have distinct roles in the regulation of heterochromatin and virulence in the fungal wheat pathogen, Zymoseptoria tritici

Autor: Callum J. Fraser, Julian C. Rutherford, Jason J. Rudd, Simon K. Whitehall

SUMMARYHeterochromatin is characterized by specific histone post-translational modifications such as the di- and tri-methylation of histone H3 on lysine 9 (H3K9me2/3), which direct the recruitment of ‘reader’ proteins to chromatin. In the fungal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e131e4d001cac41173d8f7093664308
https://doi.org/10.1101/2022.09.21.508279

Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Autor: Holly E Anderson, Alexander Kagansky, Josephine Wardle, Juri Rappsilber, Robin C Allshire, Simon K Whitehall

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13488 (2010)

HIRA (or Hir) proteins are conserved histone chaperones that function in multi-subunit complexes to mediate replication-independent nucleosome assembly. We have previously demonstrated that the Schizosaccharomyces pombe HIRA proteins, Hip1 and Slm9,

Externí odkaz: https://doaj.org/article/c149eafdf622407fa4918dc29898b975

Abo1, a conserved bromodomain AAA ‐ ATP ase, maintains global nucleosome occupancy and organisation

Autor: Csenge Gal, Lakxmi Subramanian, Robin C. Allshire, Karen M Moore, Alex J Whale, Konrad Paszkiewicz, Heather E. Murton, Kevin M. Creamer, Simon K. Whitehall, Sandra Codlin, Jürg Bähler, Nicholas A. Kent, Janet F. Partridge

Publikováno v: EMBO Reports
Gal, C, Murton, H E, Subramanian, L, Whale, A J, Moore, K M, Paszkiewicz, K, Codlin, S, Bähler, J, Creamer, K M, Partridge, J F, Allshire, R C, Kent, N A & Whitehall, S K 2016, ' Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation ', EMBO Reports, vol. 17, no. 1, pp. 79-93 . https://doi.org/10.15252/embr.201540476

Maintenance of the correct level and organisation of nucleosomes is crucial for genome function. Here, we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in the maintenance of nucleosome architecture in fission yeast. Cells lacking abo1+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff026580cc269f457127eff006bfddac
https://doi.org/10.15252/embr.201540476

Reporter Gene Silencing Assays in Fission Yeast

Autor: Simon K. Whitehall, Hugh P. Cam

Publikováno v: Cold Spring Harbor protocols. 2016(10)

Reporter gene silencing assays provide a facile method for assessing the function of heterochromatin in Schizosaccharomyces pombe. They use strains containing auxotrophic markers (commonly ura4+ or ade6+) located within a heterochromatic region. Tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40b9f414ebbea4d18be5fd9aeeaff2c
https://pubmed.ncbi.nlm.nih.gov/27698241

A homeodomain transcription factor regulates the DNA replication checkpoint in yeast

Autor: Christopher J. McInerny, Frances S. Purtill, Brian A. Morgan, Simon K. Whitehall, Andrew D. Sharrocks, Emma S. Williams

Publikováno v: Cell Cycle. 10:664-670

Checkpoints monitor the successful completion of cell cycle processes, such as DNA replication, and also regulate the expression of cell cycle-dependent genes that are required for responses. In the model yeast Schizosaccharomyces pombe G 1/S phase-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44183c45412e0018a2ed347a38dcbef8
https://doi.org/10.4161/cc.10.4.14824