Zobrazeno 1 - 10
of 9 536
pro vyhledávání: '"Simon Jones P"'
Autor:
Johnny Kenth, Elizabeth Maughan, Colin R Butler, Jasleen Gabrie, Maral Rouhani, Benjamin Silver, Olumide K Ogunbiyi, Stuart Wilkinson, Reema Nandi, Robert Walker, Nagarajan Muthialu, Simon Jones, Richard Hewitt, Iain A Bruce
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Mucopolysaccharidosis (MPS) type IVA is a rare lysosomal storage disorder caused by aberrations of the N-acetyl-galactosamine-6-sulfatase (GALNS) enzyme. MPS IVA is associated with a wide gamut of respiratory and airway disorders
Externí odkaz:
https://doaj.org/article/7834c7ec13d8457c9faf74eb47a221cb
Autor:
Hao Zhang, Neil Jethani, Simon Jones, Nicholas Genes, Vincent J Major, Ian S Jaffe, Anthony B Cardillo, Noah Heilenbach, Nadia Fazal Ali, Luke J Bonanni, Andrew J Clayburn, Zain Khera, Erica C Sadler, Jaideep Prasad, Jamie Schlacter, Kevin Liu, Benjamin Silva, Sophie Montgomery, Eric J Kim, Jacob Lester, Theodore M Hill, Alba Avoricani, Ethan Chervonski, James Davydov, William Small, Eesha Chakravartty, Himanshu Grover, John A Dodson, Abraham A Brody, Yindalon Aphinyanaphongs, Arjun Masurkar, Narges Razavian
Publikováno v:
PLOS Digital Health, Vol 3, Iss 12, p e0000685 (2024)
Ensuring reliability of Large Language Models (LLMs) in clinical tasks is crucial. Our study assesses two state-of-the-art LLMs (ChatGPT and LlaMA-2) for extracting clinical information, focusing on cognitive tests like MMSE and CDR. Our data consist
Externí odkaz:
https://doaj.org/article/a75d72ec94b64755a5f737a01e709bd9
Publikováno v:
Journal of Power Sources Advances, Vol 30, Iss , Pp 100162- (2024)
Six thermal runaway propagation tests were performed on small modules consisting of seven 21700 lithium-ion cells in a hexagonal configuration with 3 mm spacing between adjacent cells. One cell in the centre of the module was triggered into thermal r
Externí odkaz:
https://doaj.org/article/226a3a3225ba491b9e20d477759afcdb
Publikováno v:
International Journal of Digital Earth, Vol 17, Iss 1 (2024)
ABSTRACTFlood models rely on accurate topographic data representing the bare earth ground surface. In many parts of the world, the only topographic data available are the free, satellite-derived global Digital Elevation Models (DEMs). However, these
Externí odkaz:
https://doaj.org/article/87fa65b8ab4b4f3a888fbe40764fd41a
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-9 (2024)
Abstract Understanding the response of plant respiration to climate change is key to determining whether the global land carbon sink continues into the future or declines. Most global vegetation models use a classical growth-maintenance approach, whi
Externí odkaz:
https://doaj.org/article/4d74fa35b4d24a15a15be0116b4ee993
Publikováno v:
Royal Society Open Science, Vol 11, Iss 6 (2024)
This study aims to develop an automated framework for the characterization of materials which are both hyper-elastic and viscoelastic. This has been evaluated using human articular cartilage (AC). AC (26 tissue samples from 5 femoral heads) underwent
Externí odkaz:
https://doaj.org/article/4133d202229249fa942af7a80545844f
Autor:
Stuart Ellison, Karen Buckland, Yuko Learmonth, Victoria Day, Spandan Kalra, Lauren Howe, Francisco José Roman-Rodriguez, Jose Bonafont, Laura Booth, Rebecca Holley, Jon Smythe, Simon Jones, Adrian Thrasher, Claire Booth, Brian W. Bigger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101271- (2024)
Hematopoietic stem cell gene therapy (HSCGT) is a promising therapeutic strategy for the treatment of neurodegenerative, metabolic disorders. The approach involves the ex vivo introduction of a missing gene into patients’ own stem cells via lentivi
Externí odkaz:
https://doaj.org/article/c6d56cc1cb214a2393e79a6e7acc9046
Publikováno v:
Clinical Infection in Practice, Vol 22, Iss , Pp 100353- (2024)
Background: Patients with advanced HIV can present with multiple life-threatening pathologies. Disseminated histoplasmosis is an underdiagnosed infection in advanced HIV which can lead to haemophagocytic lymphohistiocytosis (HLH). Case report: A 36-y
Externí odkaz:
https://doaj.org/article/2ae907abdf7f4824a38c7f81336821d4
Autor:
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translatio
Externí odkaz:
https://doaj.org/article/ab6733cf5df64638bd28121108e81c94
Publikováno v:
JIMD Reports, Vol 64, Iss 5, Pp 346-352 (2023)
Abstract Metachromatic leukodystrophy (MLD) results from ARSA gene mutations. Affected individuals meet early milestones before neurological deterioration and early death. Atidarsagene autotemcel (arsa‐cel), an autologous haematopoietic stem cell g
Externí odkaz:
https://doaj.org/article/929b37f9ead54e64bcac05d1feb3fb18