Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Simon John Mantell"'
Publikováno v:
Expert Review of Clinical Pharmacology. 3:55-72
The broad spectrum anti-inflammatory actions of adenosine A(2A) receptor agonists are well described. The wide distribution of this receptor, however, suggests that the therapeutic potential of these agents is likely to reside in topical treatments t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc8ae4fd39b59d1d3af0542b5ff4d27
https://doi.org/10.1586/ecp.09.57
https://doi.org/10.1586/ecp.09.57
Autor:
Emilio F. Stuart, Stuart Rozze, Fiona Macintyre, D. K. Walker, Michael A. Trevethick, Sandra Marina Monaghan, Michael Yeadon, Maw Graham Nigel, Patricia Wright, Simon John Mantell, Matthew D. Selby, Helene Chavaroche, Peter T. Stephenson, Arnaud Lemaitre, David V. Batchelor, Karen N. Wright, Lynsey Whitlock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4471-4475
COPD is a major cause of mortality in the western world. A(2A) agonists are postulated to reduce the lung inflammation that causes COPD. The cardiovascular effects of A(2A) agonists dictate that a compound needs to be delivered by inhalation to be th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87c4b9e0c41f333bb6eb6cd6ff48d8f
https://doi.org/10.1016/j.bmcl.2009.05.027
https://doi.org/10.1016/j.bmcl.2009.05.027
Autor:
William A. Million, Pauline Carnell, Gareth W. Harbottle, Russell Monhemius, Simon A. Osborne, Cedric Poinsard, Maw Graham Nigel, Ben S. Greener, Karl Richard Gibson, Rebecca L. Prime, Steven England, Peter G. Dodd, Simon John Mantell, Alison Betts, Huw Rees
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2190-2194
The SAR of a series of novel pyrido[3,4-d]pyramid-4-ylamine mGluR1 antagonists is described. The multiple of the unbound K(i) in cerebrospinal fluid necessary to give morphine like analgesic effects in an electromyograph pinch model in rodents is det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedc2e644ebe905bda97f0d735bbb991
https://doi.org/10.1016/j.bmcl.2009.02.106
https://doi.org/10.1016/j.bmcl.2009.02.106
Autor:
Adrian Barnard, Michael Yeadon, Simon John Mantell, Karen N. Wright, Mike Trevethick, Emilio F. Stuart
Publikováno v:
British Journal of Pharmacology. 155:463-474
Adenosine A2A receptor agonists may be important regulators of inflammation. Such conclusions have come from studies demonstrating that, (i) adenosine A2A agonists exhibit anti-inflammatory properties in vitro and in vivo, (ii) selective A2A antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b389fb3b3f24e9751710877ac153b5f7
https://doi.org/10.1038/bjp.2008.329
https://doi.org/10.1038/bjp.2008.329
Autor:
D. K. Walker, Emilio F. Stuart, Arnaud Lemaitre, David V. Batchelor, Peter G. Dodd, Maw Graham Nigel, Helene Chavaroche, Sandra Marina Monaghan, Ruth F. Keir, Matthew D. Selby, Simon John Mantell, Tim J. Hobson, Michael A. Trevethick, Peter T. Stephenson, Stuart Rozze, Rhys M. Jones, Karen N. Wright, Michael Yeadon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1284-1287
COPD is a major cause of mortality in the western world. A(2A) agonists are postulated to reduce the lung inflammation that causes COPD. The cardiovascular effects of A(2A) agonists dictate that a compound needs to be delivered by inhalation to be th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d0869ceb904523cd82b828bbd710e4
https://doi.org/10.1016/j.bmcl.2008.01.033
https://doi.org/10.1016/j.bmcl.2008.01.033
Autor:
Charlotte Alice Louise Lane, Mike Trevethick, Russell Andrew Lewthwaite, Kim James, Christelle Perros-Huguet, Mark E. Bunnage, Rhys M. Jones, Paul Alan Glossop, David Price, Rob Webster, Simon John Mantell, Alan Daniel Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4012-4015
The design and profile of a series of saligenin containing long acting β2-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5220dac31d5223846ee0063a0531ad90
https://doi.org/10.1016/j.bmcl.2007.04.081
https://doi.org/10.1016/j.bmcl.2007.04.081
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Publikováno v:
ChemInform. 33
Loss of aromaticity ensues when N-benzoyl oxazolidines are lithiated and undergo a 6.pi. disrotatory electrocyclization. The stereochem. of the cyclization shows it to be a new example of an electrocyclic ring closure. The cis-tricyclic products epim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c7e3658081ec4eb6fca6d88d834d16
https://doi.org/10.1002/chin.200231137
https://doi.org/10.1002/chin.200231137
Autor:
Charlotte Alice Louise Lane, Mark E. Bunnage, Mark Holbrook, Simon John Mantell, Alan Daniel Brown, Christelle Perros-Huguet, Russell Andrew Lewthwaite, Rob Webster, Paul Alan Glossop, Rhys D. Jones, David Price
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
The design and profile of a series of indole containing long acting beta(2)-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cba1548fe894a3f47b488a34c0a7639
https://pubmed.ncbi.nlm.nih.gov/17897826
https://pubmed.ncbi.nlm.nih.gov/17897826