Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Simon Jenni"'
Autor:
Gabriel Dagotto, Jana L. Fisher, David Li, Zhenyu Li, Simon Jenni, Zongli Li, Lawrence J. Tartaglia, Peter Abbink, Dan H. Barouch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101350- (2024)
Adeno-associated viruses (AAVs) are popular gene therapy delivery vectors, but their application can be limited by anti-vector immunity. Both preexisting neutralizing antibodies (NAbs) and post-administration NAbs can limit transgene expression and r
Externí odkaz:
https://doaj.org/article/bb79628a310c4d358f90adeb46aad779
Autor:
Friederike M. C. Benning, Simon Jenni, Coby Y. Garcia, Tran H. Nguyen, Xuewu Zhang, Luke H. Chao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Baculoviruses are insect-infecting pathogens with wide applications as biological pesticides, in vitro protein production vehicles and gene therapy tools. Its cylindrical nucleocapsid, which encapsulates and protects the circular double-stra
Externí odkaz:
https://doaj.org/article/58d055d1925b4e73ac9c2de464ebe788
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011750 (2024)
Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles
Externí odkaz:
https://doaj.org/article/7cb334ec63d44366b72185d41a74c506
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Vesicular stomatitis virus (VSV) is the most widely studied prototype for negative-sense RNA viruses. Structure determination of VSV particles is particularly challenging because they are polymorphic with different helical symmetries. Here, Jenni et
Externí odkaz:
https://doaj.org/article/f75dbfda53a64064a00d6b05db5f925d
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between mitotic spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to obtain predictions of the Ndc80 ‘loop’ structure and of the Ndc80 : Nuf2
Externí odkaz:
https://doaj.org/article/600324cf07a44404ace8381f540dd098
Autor:
Kevin R. McCarthy, Joseph L. Timpona, Simon Jenni, Louis-Marie Bloyet, Vesna Brusic, Welkin E. Johnson, Sean P. J. Whelan, Lindsey R. Robinson-McCarthy
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT EnvP(b)1 is an endogenous retroviral envelope gene found in human and other primate genomes. We report EnvP(b)1 sequences in primate genomes consistent with an integration event between 40 and 71 million years ago. Using a highly specific po
Externí odkaz:
https://doaj.org/article/98868e82129a490397d8d207d2023a7b
Autor:
Xue Fei, Tristan A Bell, Simon Jenni, Benjamin M Stinson, Tania A Baker, Stephen C Harrison, Robert T Sauer
Publikováno v:
eLife, Vol 9 (2020)
ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and translocates specific protein substrates into the degradation chamber of ClpP. We present cryo-EM studies of the E. coli enzyme that show how asymmetric hexameric rin
Externí odkaz:
https://doaj.org/article/4a7bb2bb3e33420786905516001192e8
Autor:
Simon Jenni, Louis-Marie Bloyet, Ruben Diaz-Avalos, Bo Liang, Sean P.J. Whelan, Nikolaus Grigorieff, Stephen C. Harrison
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 53-60.e5 (2020)
Summary: The large (L) proteins of non-segmented, negative-strand RNA viruses are multifunctional enzymes that produce capped, methylated, and polyadenylated mRNA and replicate the viral genome. A phosphoprotein (P), required for efficient RNA-depend
Externí odkaz:
https://doaj.org/article/0594fe44de3e492e92ec93c34c5cb32e
Autor:
Schwartzman, Roy1 docroy_com@ncsu.edu, Simon, Jenni M.2 jmsimon@uncg.edu, Hyman, Cynthia Zuckerman1 cezucker@ncsu.edu
Publikováno v:
Proceedings of the International Conference on Gender Research (ICGR). 2024, p356-363. 8p.