Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Simon J. Webb"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Molecular biology achieves control over complex reaction networks by means of molecular systems that translate a chemical input (such as ligand binding) into an orthogonal chemical output (such as acylation or phosphorylation). We present an
Externí odkaz:
https://doaj.org/article/87f1d19e01b74c12baba99b83d9d6b2e
Autor:
Catriona McCallion, Anna D. Peters, Andrew Booth, Karen Rees-Unwin, Julie Adams, Raisa Rahi, Alain Pluen, Claire V. Hutchinson, Simon J. Webb, John Burthem
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2069-2081 (2019)
Abstract: CXC chemokine receptor 4 (CXCR4) is overexpressed by a broad range of hematological disorders, and its interaction with CXC chemokine ligand 12 (CXCL12) is of central importance in the retention and chemoprotection of neoplastic cells in th
Externí odkaz:
https://doaj.org/article/2507d194e7a244fc8e6f2e80527f29d0
Autor:
Robert Šardzík, Gavin T. Noble, Martin J. Weissenborn, Andrew Martin, Simon J. Webb, Sabine L. Flitsch
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 699-703 (2010)
The synthesis of a number of aminoethyl glycosides of cell-surface carbohydrates, which are important intermediates for glycoarray synthesis, is described. A set of protocols was developed which provide these intermediates, in a short number of steps
Externí odkaz:
https://doaj.org/article/bb2d26b91a944e6fad871952ddf99b0d
Autor:
Siyuan, Wang, Flavio, Della Sala, Matthew J, Cliff, George F S, Whitehead, Iñigo J, Vitórica-Yrezábal, Simon J, Webb
Publikováno v:
Journal of the American Chemical Society. 144(47)
Understanding and controlling peptide foldamer conformation in phospholipid bilayers is a key step toward their use as molecular information relays in membranes. To this end, a new
Autor:
Joana Silva, Reynard Spiess, Andrea Marchesi, Sabine L. Flitsch, Julie E. Gough, Simon J. Webb
Publikováno v:
Silva, J, Spiess, R, Marchesi, A, Flitsch, S L, Gough, J & Webb, S 2022, ' Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes ', Journal of Materials Chemistry B . https://doi.org/10.1039/D2TB00714B
Oxime formation is a convenient one-step method for ligating reducing sugars to surfaces, producing a mixture of closed ring α- and β-anomers along with open-chain (E)- and (Z)-isomers. Here we show that despite existing as a mixture of isomers, N-
Autor:
David P. Tilly, William Cullen, Heng Zhong, Romain Jamagne, Inigo Vitórica‐Yrezábal, Simon J. Webb
Publikováno v:
Tilly, D P, Cullen, W, Zhong, H, Jamagne, R, Vitórica-yrezábal, I & Webb, S J 2022, ' α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202104293
To investigate how remotely induced changes in ligand folding might affect catalysis by organometallic complexes, dynamic α-amino-iso-butyric acid (Aib) peptide foldamers bearing rhodium(I) N-heterocyclic carbene (NHC) complexes have been synthesise
Publikováno v:
Chivers, P R A, Dookie, R S, Gough, J & Webb, S 2020, ' Photo-dissociation of self-assembled (anthracene-2-carbonyl)amino acid hydrogels ', Chemical Communications . https://doi.org/10.1039/D0CC05292B
Amino acids modified with an N-terminal anthracene group self-assemble into supramolecular hydrogels upon the addition of a range of salts or cell culture medium. Gel-phase photo-dimerisation of gelators results in hydrogel disassembly and was used t
Autor:
Ewan W. Blanch, Petr Bouř, Valery Andrushchenko, Damien Jefferies, Simon J. Webb, William Cullen, Jonathan Clayden, Alison Rodger, Mario Campana, Maria Giovanna Lizio, Nikola Paul Chmel, Matteo De Poli, Syma Khalid
Publikováno v:
Lizio, M G, Campana, M, De Poli, M, Jefferies, D F, Cullen, W, Andrushchenko, V, Chmel, N P, Bouř, P, Khalid, S, Clayden, J, Blanch, E, Rodger, A & Webb, S J 2021, ' Insight into the Mechanism of Action and Peptide-Membrane Interactions of Aib-Rich Peptides : Multitechnique Experimental and Theoretical Analysis ', ChemBioChem, vol. 22, no. 9, pp. 1656-1667 . https://doi.org/10.1002/cbic.202000834
Lizio, M G, Campana, M, De Poli, M, Jefferies, D F, Cullen, W, Andrushchenko, V, Chmel, N P, Bouř, P, Khalid, S, Clayden, J, Blanch, E, Rodger, A & Webb, S J 2021, ' Insight into mechanism of action and peptide-membrane interactions of Aib-rich peptides: multi-technique experimental and theoretical analysis ', CHEMBIOCHEM . https://doi.org/10.1002/cbic.202000834
Chembiochem
Lizio, M G, Campana, M, De Poli, M, Jefferies, D F, Cullen, W, Andrushchenko, V, Chmel, N P, Bouř, P, Khalid, S, Clayden, J, Blanch, E, Rodger, A & Webb, S J 2021, ' Insight into mechanism of action and peptide-membrane interactions of Aib-rich peptides: multi-technique experimental and theoretical analysis ', CHEMBIOCHEM . https://doi.org/10.1002/cbic.202000834
Chembiochem
The increase in resistant bacterial strains necessitates the identification of new antimicrobial molecules. Antimicrobial peptides (AMPs) are an attractive option because of evidence that bacteria cannot easily develop resistance to AMPs. The peptaib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0087fa0e61c60f6dc86043a4a7956c75
https://hdl.handle.net/1983/44639f3f-aeda-4cf3-879f-9d03b54d4a51
https://hdl.handle.net/1983/44639f3f-aeda-4cf3-879f-9d03b54d4a51
Publikováno v:
Wrackmeyer, M, O’rourke, A P, Pugh, T, Turner, M L & Webb, S J 2021, ' Effect of varying substituent on the colour change transitions of diacetylene pigments ', Dyes and pigments, pp. 109397 . https://doi.org/10.1016/j.dyepig.2021.109397
A library of closely related diacetylenes has been synthesised, comprising docosa-10,12-diynediamides with small n-alkyl or cycloalkyl substituents on the termini. Colour changes of these solids in response to ultraviolet (UV) radiation and heating w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e545d46829981aa9336ab8d28ca582b
https://doi.org/10.1016/j.dyepig.2021.109397
https://doi.org/10.1016/j.dyepig.2021.109397
Autor:
Bryden A. F. Le Bailly, Natasha Eccles, Iñigo J. Vitorica-Yrezabal, Simon J. Webb, Jonathan Clayden, Flavio della Sala
Publikováno v:
Eccles, N, Le Bailly, B A F, Della Sala, F, Vitórica-Yrezábal, I J, Clayden, J & Webb, S J 2019, ' Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers ', Chemical communications (Cambridge, England), vol. 55, no. 63, pp. 9331-9334 . https://doi.org/10.1039/c9cc03895g
Eccles, N, Le Bailly, B, Della Sala, F, Vitorica-yrzebal, I, Clayden, J & Webb, S 2019, ' Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers ', Chemical Communications . https://doi.org/10.1039/C9CC03895G
Eccles, N, Le Bailly, B, Della Sala, F, Vitorica-yrzebal, I, Clayden, J & Webb, S 2019, ' Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers ', Chemical Communications . https://doi.org/10.1039/C9CC03895G
A crystallographically characterised zinc(ii)-capped foldamer can sense the enantiomeric excess of scalemic carboxylate solutions, including those produced by enantioselective organocatalysis, and can relay this input signal along the foldamer body t