Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Simon J. Waddell"'
Autor:
Brindha Gap-Gaupool, Sarah M. Glenn, Emily Milburn, Obolbek Turapov, Marialuisa Crosatti, Jennifer Hincks, Bradley Stewart, Joanna Bacon, Sharon L. Kendall, Martin I. Voskuil, Olga Riabova, Natalia Monakhova, Jeffrey Green, Simon J. Waddell, Vadim A. Makarov, Galina V. Mukamolova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract During infection Mycobacterium tuberculosis (Mtb) forms physiologically distinct subpopulations that are recalcitrant to treatment and undetectable using standard diagnostics. These difficult to culture or differentially culturable (DC) Mtb
Externí odkaz:
https://doaj.org/article/036ab31366e34a5191d2bed82482e8a4
Autor:
Nicoletta Campolattano, Gianluca D’Abrosca, Luigi Russo, Barbara De Siena, Milena Della Gala, Ida De Chiara, Rosangela Marasco, Aaron Goff, Simon J. Waddell, Margherita Sacco, Lidia Muscariello
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Drug resistance is one of the most difficult challenges facing tuberculosis (TB) control. Drug efflux is among the mechanisms leading to drug resistance. In our previous studies, we partially characterized the ABC-type MSMEG-3762/63 efflux p
Externí odkaz:
https://doaj.org/article/0d5b0b9409b040cb8a8cbbc5e6a9433e
Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan
Autor:
Gary Napier, Anwar Sheed Khan, Abdul Jabbar, Muhammad Tahir Khan, Sajid Ali, Muhammad Qasim, Noor Mohammad, Rumina Hasan, Zahra Hasan, Susana Campino, Sajjad Ahmad, Baharullah Khattak, Simon J. Waddell, Taj Ali Khan, Jody E. Phelan, Taane G. Clark
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan, with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control. Whole genome sequencing (WGS) of M. tuberculosis is being us
Externí odkaz:
https://doaj.org/article/e9e9a17025eb4d2199855338fa7f1d4e
Autor:
Daniel Mekonnen, Awoke Derbie, Adane Mihret, Solomon Abebe Yimer, Tone Tønjum, Baye Gelaw, Endalkachew Nibret, Abaineh Munshae, Simon J. Waddell, Abraham Aseffa
Publikováno v:
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-13 (2021)
Abstract Mycobacterium tuberculosis (Mtb), the main etiology of tuberculosis (TB), is predominantly an intracellular pathogen that has caused infection, disease and death in humans for centuries. Lipid droplets (LDs) are dynamic intracellular organel
Externí odkaz:
https://doaj.org/article/971f41638d694e84931616db0f8c2d92
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Mycobacteria naturally grow as corded biofilms in liquid media without detergent. Such detergent-free biofilm phenotypes may reflect the growth pattern of bacilli in tuberculous lung lesions. New strategies are required to treat tuberculosis
Externí odkaz:
https://doaj.org/article/e7819f1bcebf4e7a86cd42bb30477b29
Autor:
Joanna Houghton, Angela Rodgers, Graham Rose, Alexandre D’Halluin, Terry Kipkorir, Declan Barker, Simon J. Waddell, Kristine B. Arnvig
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Almost 140 years after the identification of Mycobacterium tuberculosis as the etiological agent of tuberculosis, important aspects of its biology remain poorly described. Little is known about the role of posttranscriptional control of gene
Externí odkaz:
https://doaj.org/article/1f0df0280f7b41aa8779259b5895a1bf
Autor:
Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish larvae, selecting for those that protected lateral-line hair cell
Externí odkaz:
https://doaj.org/article/581c6dc4787e4df088decf8ef38ca7aa
Autor:
Luiz A. E. Pollo, Erlon F. Martin, Vanessa R. Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J. Waddell, Maique W. Biavatti, Louis P. Sandjo
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
Drug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive chemical diversity and inspiration for
Externí odkaz:
https://doaj.org/article/a5bc17ab6ed24dc3902629fe70006e5a
Autor:
Barbara De Siena, Nicoletta Campolattano, Gianluca D’Abrosca, Luigi Russo, Daire Cantillon, Rosangela Marasco, Lidia Muscariello, Simon J. Waddell, Margherita Sacco
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Multi-drug resistant tuberculosis (MDR-TB) represents a major health problem worldwide. Drug efflux and the activity of efflux transporters likely play important roles in the development of drug-tolerant and drug-resistant mycobacterial phenotypes. T
Externí odkaz:
https://doaj.org/article/f4407709c724465bb024ea2e121c693e
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Staphylococcus aureus is a common cause of chronic and relapsing infection, especially when the ability of the immune system to sterilize a focus of infection is compromised (e.g., because of a foreign body or in the cystic fibrosis lung). Chronic in
Externí odkaz:
https://doaj.org/article/d3b95b4caa4e479abe68cfd237caf08d