Participants in the Trans-Antarctic Winter Traverse Expedition Showed Increased Bacterial Load and Diversity in Saliva but Maintained Individual Differences within Stool Microbiota and Across Metabolite Fingerprints

Autor: Simon J. S. Cameron, Arwyn Edwards, Robert J. Lambert, Mike Stroud, Luis A. J. Mur

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4850 (2023)

Understanding the impact of long-term physiological and environmental stress on the human microbiota and metabolome may be important for the success of space flight. This work is logistically difficult and has a limited number of available participan

Externí odkaz: https://doaj.org/article/3e6565f1ae664df4b573b9af1beccf29

A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer.

Autor: Simon J S Cameron, Keir E Lewis, Sharon A Huws, Matthew J Hegarty, Paul D Lewis, Justin A Pachebat, Luis A J Mur

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177062 (2017)

Lung cancer (LC) is the most prevalent cancer worldwide, and responsible for over 1.3 million deaths each year. Currently, LC has a low five year survival rates relative to other cancers, and thus, novel methods to screen for and diagnose malignancie

Externí odkaz: https://doaj.org/article/f10fa8fb422848ff8e1c5f5828fcc4ec

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth

Autor: L Kindinger, Julie A. K. McDonald, Vasso Terzidou, Phillip R. Bennett, Katia Capuccini, Denise Chan, Holly V. Lewis, Anna L. David, Lynne Sykes, David A. MacIntyre, Zoltan Takats, Jane E. Norman, Paolo Inglese, Sarah J. Stock, Kate Alexander-Hardiman, Yun S. Lee, Julian Marchesi, Richard G. Brown, Pamela Pruski, Simon J S Cameron, T. G. Teoh, Ann Smith, Gonçalo D S Correia

Publikováno v: Pruski, P, dos Santos Correia, G, Lewis, H, Capuccini, K, Inglese, P, Chan, D, Brown, R, Kindinger, L, Lee, Y, Smith, A, Marchesi, J, McDonald, J, Cameron, S, Alexander-Hardiman, K, David, A, Stock, S J E, Norman, J, Terzidou, V, Teoh, TG, Sykes, L, Bennett, P, Takats, Z & MacIntyre, D 2021, ' Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth ', Nature Communications, vol. 12, 5967 . https://doi.org/10.1038/s41467-021-26215-w
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Pruski, P, Correia, G D S, Lewis, H V, Capuccini, K, Inglese, P, Chan, D, Brown, R G, Kindinger, L, Lee, Y S, Smith, A, Marchesi, J, McDonald, J A K, Cameron, S, Alexander-Hardiman, K, David, A L, Stock, S J, Norman, J E, Terzidou, V, Teoh, T G, Sykes, L, Bennett, P R, Takats, Z & MacIntyre, D A 2021, ' Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth ', Nature Communications, vol. 12, no. 1, 5967, pp. 5967 . https://doi.org/10.1038/s41467-021-26215-w
Nature Communications

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24442bae3a4714f17dbbc25b9e14db7c
http://hdl.handle.net/10044/1/92499

Sample Preparation Free Mass Spectrometry Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry: Applications to Microbiology, Metabolic Biofluid Phenotyping, and Food Authenticity

Autor: Richard Schaffer, Adam Burke, Kate Alexander-Hardiman, Julia Balog, Lynn Vanhaecke, Simon J S Cameron, Tony Rickards, Tamás Karancsi, Monica Rebec, Daniel Simon, Alvaro Perdones-Montero, Lieven Van Meulebroek, Sara Stead, Zoltan Takats

Publikováno v: Cameron, S J S, Perdones-Montero, A, Van Meulebroek, L, Burke, A, Alexander-Hardiman, K, Simon, D, Schaffer, R, Balog, J, Karancsi, T, Rickards, T, Rebec, M, Stead, S, Vanhaecke, L & Takáts, Z 2021, ' Sample preparation free mass spectrometry using laser-assisted rapid evaporative Ionization mass spectrometry: applications to microbiology, metabolic biofluid phenotyping, and food authenticity ', Journal of the American Society for Mass Spectrometry, vol. 32, no. 6, pp. 1393–1401 . https://doi.org/10.1021/jasms.0c00452

Mass spectrometry has established itself as a powerful tool in the chemical, biological, medical, environmental, and agricultural fields. However, experimental approaches and potential application areas have been limited by a traditional reliance on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9cc30ac49b2428e8f329986912a2f5
https://pubmed.ncbi.nlm.nih.gov/33980015

Rapid ex vivo molecular fingerprinting of biofluids using laser-assisted rapid evaporative ionization mass spectrometry

Autor: Vera, Plekhova, Lieven, Van Meulebroek, Marilyn, De Graeve, Alvaro, Perdones-Montero, Margot, De Spiegeleer, Ellen, De Paepe, Emma, Van de Walle, Zoltan, Takats, Simon J S, Cameron, Lynn, Vanhaecke

Publikováno v: Nature protocols. 16(9)

Of the many metabolites involved in any clinical condition, only a narrow range of biomarkers is currently being used in the clinical setting. A key to personalized medicine would be to extend this range. Metabolic fingerprinting provides a more comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::411aee4b8e0cd60bd681208509a2a9f4
https://pubmed.ncbi.nlm.nih.gov/34341579