Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Simon J. Powis"'
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 3, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs) frequently express human leukocyte antigen class I (HLA‐I) molecules. The immunopeptidomes presented on EV HLA‐I are being mapped to provide key information on both specific cancer‐related peptides, and for
Externí odkaz:
https://doaj.org/article/1b69069a367b408cb5fe31c136db06fd
Autor:
Andrew T. Meek, Nils M. Kronenberg, Andrew Morton, Philipp Liehm, Jan Murawski, Eleni Dalaka, Jonathan H. Booth, Simon J. Powis, Malte C. Gather
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Studying dynamic processes in mechanobiology has been challenging due to lack of appropriate tools. Here, the authors present an interference-based method, illuminated via two rapidly alternating wavelengths, which enables real-time mapping of nanosc
Externí odkaz:
https://doaj.org/article/024965871d1b44808d4b07ef44378a64
Autor:
Izabela Lenart, Linh-Huyen Truong, Dinh Dung Nguyen, Olga Rasiukienė, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Branca I. Pereira, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific peptide fused to the light chain beta-2 microglobulin (β2m) and MHC class I heavy chain (HC) by
Externí odkaz:
https://doaj.org/article/26544435c75247c3bb82baf2f7945318
Autor:
Janos Kriston-Vizi, Izabela Lenart, Takao Iwawaki, Keith Gould, Darren Nesbeth, Simon J. Powis, Antony N. Antoniou
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
Salmonella enteritica (S. enteritica) induce and require unfolded protein response (UPR) pathways for intracellular replication. Salmonella infections can lead to reactive arthritis (ReA), which can exhibit associations with Human Leucocyte Antigen (
Externí odkaz:
https://doaj.org/article/e1f17209df0f45c4be8518d747297ce9
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-4 (2019)
Abstract Objectives Salmonella bacteria can induce the unfolded protein response, a cellular stress response to misfolding proteins within the endoplasmic reticulum. Salmonella can exploit the host unfolded protein response leading to enhanced bacter
Externí odkaz:
https://doaj.org/article/119285ecfc40459b9cbc684cb9c6edcb
Autor:
Alasdair H. Fikouras, Marcel Schubert, Markus Karl, Jothi D. Kumar, Simon J. Powis, Andrea Di Falco, Malte C. Gather
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
While the sharp emission lines of microlasers are advantageous for cell tagging, their relatively large size can impede cell migration and behavior. Here, Fikouras et al. develop nano-sized lasers that can readily tag and track various types of cells
Externí odkaz:
https://doaj.org/article/5dbcc6f29809447b853f1a9cb02f8875
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13554 (2021)
The Human Leukocyte Antigen class I (HLA-I) system is an essential part of the immune system that is fundamental to the successful activation of cytotoxic lymphocytes, and an effective subsequent immune attack against both pathogen-infected and cance
Externí odkaz:
https://doaj.org/article/8fe8c14e165d48edb3fe5b6205a60bfd
Autor:
Won Young Moon, Simon J. Powis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer cell deficiency (NKD) is a primary immunodeficiency where the main defect lies in CD56+CD3− natural killer (NK) cells which mediate cytotoxicity against tumors. Most cases are observed in children and adolescents with recurrent viral
Externí odkaz:
https://doaj.org/article/48cbaa0cd5c94664a56df8ab53d17e5e
Autor:
Jonas JW Kuiper, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Seçil Vural, Ina Kötter, Marleen G van de Sande, Ayşe Boyvat, Joke H de Boer, George Bertsias, Niek de Vries, Charlotte LM Krieckaert, Inês Leal, Nataša Vidovič Valentinčič, Ilknur Tugal-Tutkun, Hanane el Khaldi Ahanach, Félicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Lötscher, Floor G Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Böhm, Kees Bosman, Tony J Kenna, Simon J Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik JU Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G McGonagle, Franktien Turkstra
Publikováno v:
Kuiper, Jonas Jw; Prinz, Jörg C; Stratikos, Efstratios; Kuśnierczyk, Piotr; Arakawa, Akiko; Springer, Sebastian; Mintoff, Dillon; Padjen, Ivan; Shumnalieva, Russka; Vural, Seçil; Kötter, Ina; van de Sande, Marleen G; Boyvat, Ayşe; de Boer, Joke H; Bertsias, George; de Vries, Niek; Krieckaert, Charlotte Lm; Leal, Inês; Vidovič Valentinčič, Nataša; Tugal-Tutkun, Ilknur; ... (2023). EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders. Annals of the rheumatic diseases, 82(7), pp. 887-896. BMJ Publishing Group 10.1136/ard-2022-222852
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with
Autor:
Pankaj Kumar, Caitlin Boyne, Sydney Brown, Ayesha Qureshi, Peter Thorpe, Silvia A. Synowsky, Sally Shirran, Simon J. Powis
Publikováno v:
ImmunologyREFERENCES. 166(2)
Funding: Breast Cancer Now (Grant Number(s): 2018JulPR1086), Wellcome Trust (GrantNumber(s): 105621/Z/14/Z), Melville Charitable Trust. The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells