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pro vyhledávání: '"Simon J. Lawless"'
Autor:
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their micr
Externí odkaz:
https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002
Autor:
Simon J. Lawless, Ursula Warthorst, Erika L. Pearce, Joerg M. Buescher, Mauro Corrado, Gabriele Niedermann, Ryan Kyle, Annette E. Patterson, Lana Vandersarren, Tobias B. Huber, Elke Firat, David E. Sanin, Angelika S. Rambold, Oliver Kretz, Bart N. Lambrecht, Jing Qiu, George Caputa, Michael D. Buck, Anne Rensing-Ehl, Ramon I. Klein Geltink, Beth Kelly, Xuekai Zhu, David O’Sullivan, Sophie Janssens, Katarzyna M. Grzes, Jonathan D. Curtis, Anna Bremser, Edward J. Pearce
Publikováno v:
Cell
T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca27bc36abe55ad1d579f81597d113c
https://hdl.handle.net/21.11116/0000-0005-C3E3-E11858/00-001M-0000-002E-8575-1
https://hdl.handle.net/21.11116/0000-0005-C3E3-E11858/00-001M-0000-002E-8575-1
Autor:
Simon J. Lawless, Fabian Hässler, Stanley Ching-Cheng Huang, Michael D. Buck, Francesc Baixauli, Ramon I. Klein Geltink, Erika L. Pearce, Annette E. Patterson, Christina M. O’Neill, Katarzyna M. Grzes, David E. Sanin, Jing Qiu, David O’Sullivan, Jonathan D. Curtis, Duojiao Wu, Mai Matsushita, Mauro Corrado, Edward J. Pearce, Matteo Villa, Nikki van Teijlingen Bakker, Alanna M. Cameron, Agnieszka M. Kabat, Gerhard Mittler
Publikováno v:
Immunity. 49:1021-1033.e6
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δ
Publikováno v:
Seminars in Immunology
Innate immunity is the first line of defense against invading pathogens. Changes in both metabolism and chromatin accessibility contribute to the shaping of these innate immune responses, and we are beginning to appreciate that cross-talk between the