Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Simon J. Heales"'
Autor:
Angela McNelly, Anne Langan, Danielle E. Bear, Alexandria Page, Tim Martin, Fatima Seidu, Filipa Santos, Kieron Rooney, Kaifeng Liang, Simon J. Heales, Tomas Baldwin, Isabelle Alldritt, Hannah Crossland, Philip J. Atherton, Daniel Wilkinson, Hugh Montgomery, John Prowle, Rupert Pearse, Simon Eaton, Zudin A. Puthucheary
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Bioenergetic failure caused by impaired utilisation of glucose and fatty acids contributes to organ dysfunction across multiple tissues in critical illness. Ketone bodies may form an alternative substrate source, but the feasibility and safe
Externí odkaz:
https://doaj.org/article/fc2bdd73d9d84cb288bed97655efdd19
Autor:
Lotta Parviainen, Sybille Dihanich, Greg W. Anderson, Andrew M. Wong, Helen R. Brooks, Rosella Abeti, Payam Rezaie, Giovanna Lalli, Simon Pope, Simon J. Heales, Hannah M. Mitchison, Brenda P. Williams, Jonathan D. Cooper
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-21 (2017)
Abstract The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically occurs early in disease progressi
Externí odkaz:
https://doaj.org/article/3fb268f03bd943c5b78884dc1a176f68
Autor:
Kathleen Keatley, Samuel Stromei-Cleroux, Tammy Wiltshire, Nina Rajala, Gary Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan, Simon J. Heales, Geoffrey J. Pilkington, Brigitte Meunier, John E. McGeehan, Iain P. Hargreaves, Rhiannon E. McGeehan
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3364 (2019)
Glioblastoma is the most common and malignant primary brain tumour in adults, with a dismal prognosis. This is partly due to considerable inter- and intra-tumour heterogeneity. Changes in the cellular energy-producing mitochondrial respiratory chain
Externí odkaz:
https://doaj.org/article/0099cc077a444987ab0fa88885d12c8e
Autor:
Angela McNelly, Anne Langan, Danielle E. Bear, Alexandria Page, Tim Martin, Fatima Seidu, Filipa Santos, Kieron Rooney, Kaifeng Liang, Tomas Baldwin, Simon J Heales, Isabelle Alldritt, Hannah Crossland, Philip J. Atherton, Daniel Wilkinson, Hugh Montgomery, John Prowle, Rupert Pearse, Simon Eaton, Zudin A. Puthucheary
Bioenergetic failure caused by impaired utilisation of glucose and fatty acids contributes to organ dysfunction across multiple tissues in critical illness. Ketone bodies may form an alternative substrate source, but the feasibility and safety of ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5124039c6df20d967613be07e86969ae
https://doi.org/10.1101/2023.03.30.23287849
https://doi.org/10.1101/2023.03.30.23287849
Autor:
Laura, Dunn, George Fg, Allen, Adamantios, Mamais, Helen, Ling, Abi, Li, Kate E, Duberley, Iain P, Hargreaves, Simon, Pope, Janice L, Holton, Andrew, Lees, Simon J, Heales, Rina, Bandopadhyay
Publikováno v:
Neurobiology of Aging
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death. In rodents, inhibition of this pathway
Autor:
Emma L, Mead, Angelina, Mosley, Simon, Eaton, Lucianne, Dobson, Simon J, Heales, Jennifer M, Pocock
Publikováno v:
Journal of neurochemistry. 121(2)
Microglia express three isoforms of the NADPH oxidase, Nox1, Nox2 and Nox4, with the potential to produce superoxide (O(2) ˙(-) ). Microglia also express neurotransmitter receptors, which can modulate microglial responses. In this study, microglial