Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Simon J. Davis"'
Autor:
Sam Daly, João Ferreira Fernandes, Ezra Bruggeman, Anoushka Handa, Ruby Peters, Sarah Benaissa, Boya Zhang, Joseph S. Beckwith, Edward W. Sanders, Ruth R. Sims, David Klenerman, Simon J. Davis, Kevin O’Holleran, Steven F. Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Volumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and comple
Externí odkaz:
https://doaj.org/article/c36760769e7f4f429745b5a08a5a2651
Autor:
Edison Serrano, Jean Karen Lefillanca, Jaime Carrasco, Simon J. Davis, Adrian J. Hernandez Arias
Publikováno v:
Aquaculture Reports, Vol 34, Iss , Pp 101919- (2024)
This study aimed to investigate the effects of dietary inclusion of Andean lupin (Lupinus mutabilis) on the growth performance, carcass composition, liver histology, and nutrient digestibility in rainbow trout (Oncorhynchus mykiss) juveniles. The exp
Externí odkaz:
https://doaj.org/article/3f3eb02afcbe40ce8fdc6eca2eac7f49
Autor:
Anusyah Rathakrishnan, Ana L. Reis, Vlad Petrovan, Lynnette C. Goatley, Katy Moffat, Yuan Lui, Mai T. Vuong, Shinji Ikemizu, Simon J. Davis, Linda K. Dixon
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in
Externí odkaz:
https://doaj.org/article/f20f1127e5e54fceacc00ca1de7a56ff
Autor:
Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated
Externí odkaz:
https://doaj.org/article/e163cebf0d034cc0b49fca7e959be290
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The mechanistic detail of how PD-1 inhibits T cell activation is lacking. Here, the authors show PD-1 suppresses the cooperative TCR–pMHC–CD8 interaction by inhibiting TCR proximal signalling.
Externí odkaz:
https://doaj.org/article/2e4502623e2b43e3b586f623ee548395
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses by many orders of magnitude – bey
Externí odkaz:
https://doaj.org/article/718d990dbd3f4b5ab090986fc4573a64
Autor:
James H. Felce, Sarah L. Latty, Rachel G. Knox, Susan R. Mattick, Yuan Lui, Steven F. Lee, David Klenerman, Simon J. Davis
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2654-2665 (2017)
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors. Here, we use a large-scal
Externí odkaz:
https://doaj.org/article/ac280b470ad0472b9932a24d661938b7
Autor:
Christopher Paluch, Ana Mafalda Santos, Consuelo Anzilotti, Richard J. Cornall, Simon J. Davis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged—immune related adverse events. The observat
Externí odkaz:
https://doaj.org/article/673980b531654510a0d8ba4795ba7cb5
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The first step of the adaptive immune response involves the interaction of T cells that express T-cell receptors (TCRs) with peptide-loaded major histocompatibility complexes expressed by antigen-presenting cells (APCs). Exactly how this leads to act
Externí odkaz:
https://doaj.org/article/f782c0a93fd944d098614a91034699df
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The immune system serves as a crucial line of defense from infection and cancer, while also contributing to tissue homeostasis. Communication between immune cells is mediated by small soluble factors called cytokines, and also by direct cellular inte
Externí odkaz:
https://doaj.org/article/40c2a99cdf97412bb302d1b9b9fcd0df