The Logic of Developing Neocortical Circuits in Health and Disease

Autor: Bradley Voytek, Simon Hippenmeyer, Jessica A. Cardin, Simon J. B. Butt, Alysson R. Muotri, Natalia V. De Marco García, Ileana L. Hanganu-Opatz

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 5
J Neurosci

The sensory and cognitive abilities of the mammalian neocortex are underpinned by intricate columnar and laminar circuits formed from an array of diverse neuronal populations. One approach to determining how interactions between these circuit compone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d928cac4958076c07bb05b91cf334a
https://doi.org/10.1523/jneurosci.1655-20.2020

Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

Autor: Anna Hoerder-Suabedissen, Yasushi Nakagawa, Andre Marques-Smith, Filippo Ghezzi, Zoltán Molnár, Alexandra Rowett, Simon J. B. Butt, Daniel Lyngholm, Gokul Parameswaran, Paul G. Anastasiades, Cristiana Vagnoni

Publikováno v: eLife, Vol 10 (2021)
Ghezzi, F, Marques-Smith, A, Anastasiades, P G, Lyngholm, D, Vagnoni, C, Rowett, A, Parameswaran, G, Hoerder-Suabedissen, A, Nakagawa, Y, Molnar, Z & Butt, S J B 2021, ' Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex ', eLife, vol. 10, e60810 . https://doi.org/10.7554/eLife.60810
eLife

Subplate neurons (SPNs) are thought to play a role in nascent sensory processing in neocortex. To better understand how heterogeneity within this population relates to emergent function, we investigated the synaptic connectivity of Lpar1-EGFP SPNs th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9154a5386b8c29ca242c6975d50eab5
https://elifesciences.org/articles/60810

Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

Autor: Simon J. B. Butt, Filippo Ghezzi, Cristiana Vagnoni, Zoltán Molnár, Sara Ratti, Liad J. Baruchin

Development of the cortical circuits for sensory-motor processing require the coordinated integration of both columnar and long-range synaptic connections. To understand how this occurs at the level of individual neurons we have explored the timeline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad3c8a6002926231ade3b18f507669e
https://doi.org/10.1101/2020.07.01.182238

The spineless origins of prefrontal cortex dysfunction and psychiatric disorders

Autor: Simon J. B. Butt, Armin Lak

Fundamental research into early circuits of the neocortex provides insight into the etiology of mental illness. In this issue of Neuron, Chini et al. (2020) probe the consequences of combined genetic and environmental perturbation on emergent network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580421fbeddd2b3d81457d3c204a2791
https://ora.ox.ac.uk/objects/uuid:a525d1b3-4a0c-4c79-9ba4-a6fa3d870c5f

Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice

Autor: Tomasz Schneider, Luiz G. Guidi, Antonio Velayos-Baeza, Daniel Lyngholm, Zoltán Molnár, Melissa A. G. Bailey, Isabel Martinez-Garay, Timothy Donnison, Zoe G. Holloway, Simon J. B. Butt, Anthony P. Monaco

Publikováno v: Brain Structure & Function

Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia-susceptibility genes, including KIAA0319, DYX1C1, and DCDC2, have been identified in hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5dc7c3a0b1672a1dcc0dfcab3a071e
https://doi.org/10.1007/s00429-016-1282-1