Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Simon J R Heales"'
1
Akademický článek
Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCT
Autor: Natasha E Schoeler, Louise Marston, Laura Lyons, Sally Halsall, Ruchika Jain, Siobhan Titre-Johnson, Maryam Balogun, Simon J R Heales, Simon Eaton, Michael Orford, Elizabeth Neal, Christin Eltze, Elma Stephen, Andrew A Mallick, Finbar O’Callaghan, Shakti Agrawal, Alasdair Parker, Martin Kirkpatrick, Andreas Brunklaus, Ailsa McLellan, Helen McCullagh, Rajib Samanta, Rachel Kneen, Hui Jeen Tan, Anita Devlin, Manish Prasad, Rohini Rattihalli, Helen Basu, Archana Desurkar, Ruth Williams, Penny Fallon, Irwin Nazareth, Nicholas Freemantle, J Helen Cross
Publikováno v: Efficacy and Mechanism Evaluation, Vol 11, Iss 16 (2024)
Background Many infancy-onset epilepsies have a poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in older children and adults unresponsive to antiseizure medicines. We aimed to determine the effe
Externí odkaz: https://doaj.org/article/3cbdf6bf151e43c59877574331e8adad
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2
CoQ10 Deficient Endothelial Cell Culture Model for the Investigation of CoQ10 Blood–Brain Barrier Transport
Autor: Charles Turner, Luke Wainwright, Jane E. Preston, Simon J R Heales, R Neil Dalton, N. Joan Abbott, Ana R. Georgian, Iain P. Hargreaves
Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 10
Journal of Clinical Medicine, Vol 9, Iss 3236, p 3236 (2020)
Primary coenzyme Q10 (CoQ10) deficiency is unique among mitochondrial respiratory chain disorders in that it is potentially treatable if high-dose CoQ10 supplements are given in the early stages of the disease.While supplements improve peripheral abn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfe025687dad367a2d764c12a322796
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3
Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard
Autor: Kate E C, Duberley, Iain P, Hargreaves, Korn-Anong, Chaiwatanasirikul, Simon J R, Heales, John M, Land, Shamima, Rahman, Kevin, Mills, Simon, Eaton
Publikováno v: Rapid communications in mass spectrometry : RCM. 27(9)
Neurological dysfunction is common in primary coenzyme Q10 (2,3-dimethoxy, 5-methyl, 6-polyisoprene parabenzoquinone; CoQ10 ; ubiquinone) deficiencies, the most readily treatable subgroup of mitochondrial disorders. Therapeutic benefit from CoQ10 sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f238f57b9bf853867c9b160f1ea69c
https://pubmed.ncbi.nlm.nih.gov/23592193
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4
Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states
Autor: George F G, Allen, Viruna, Neergheen, Marcus, Oppenheim, Julia C, Fitzgerald, Emma, Footitt, Keith, Hyland, Peter T, Clayton, John M, Land, Simon J R, Heales
Publikováno v: Journal of neurochemistry. 114(1)
Pyridoxal 5'-phosphate, the active form of vitamin B(6), is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyses the final stage in the production of the neurotransmitters dopamine and serotonin. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbb19471f8aa1ebc3e3449de466338fc
https://pubmed.ncbi.nlm.nih.gov/20403077
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6
Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase
Autor: Victoria C, Stewart, Rebecca, Stone, Matthew E, Gegg, Martyn A, Sharpe, Roger D, Hurst, John B, Clark, Simon J R, Heales
Publikováno v: Journal of neurochemistry. 83(4)
Cultured rat and human astrocytes and rat neurones were shown to release reduced glutathione (GSH). In addition, GSH oxidation was retarded by the concomitant release of a factor from the cells. One possibility is that this factor is extracellular su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::207729dde19e3ac5fe6c0e55fd51f994
https://pubmed.ncbi.nlm.nih.gov/12421371
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7
Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass
Autor: Jake, Jacobson, Michael R, Duchen, Simon J R, Heales
Publikováno v: Journal of neurochemistry. 82(2)
Cardiolipin, a polyunsaturated acidic phospholipid, is found exclusively in bacterial and mitochondrial membranes where it is intimately associated with the enzyme complexes of the respiratory chain. Cardiolipin structure and concentration are centra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72c129eb40d08c035e3d730da0e35488
https://pubmed.ncbi.nlm.nih.gov/12124423
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8
Akademický článek
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9
Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin
Autor: Irmgard Ziegler, John A. Blair, Christian Meinschad, Simon J. R. Heales
Publikováno v: Cell Biochemistry and Function. 6:191-195
Luminol-dependent chemiluminescence of normal human monocytes activated by zymosan is demonstrated to be inhibited by tetrahydrobiopterin in a concentration-dependent manner. The reduced pterins tetrahydrobiopterin, dihydrobiopterin, and dihydroneopt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadc337b425b81012b25e6697fc2c974
https://doi.org/10.1002/cbf.290060307
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