Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Simon J Gibbons"'
Autor:
Simon J Gibbons, Madhusudan Grover, Kyoung Moo Choi, Akhilesh Wadhwa, Adeel Zubair, Laura A Wilson, Yanhong Wu, Thomas L Abell, William L Hasler, Kenneth L Koch, Richard W McCallum, Linda A B Nguyen, Henry P Parkman, Irene Sarosiek, William J Snape, James Tonascia, Frank A Hamilton, Pankaj J Pasricha, Gianrico Farrugia
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187772 (2017)
Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in
Externí odkaz:
https://doaj.org/article/0139eeb3234f4160abab2a2ff66b52ae
Autor:
Yujiro Hayashi, David T Asuzu, Simon J Gibbons, Kirsten H Aarsvold, Michael R Bardsley, Gwen A Lomberk, Angela J Mathison, Michael L Kendrick, K Robert Shen, Takahiro Taguchi, Anu Gupta, Brian P Rubin, Jonathan A Fletcher, Gianrico Farrugia, Raul A Urrutia, Tamas Ordog
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76822 (2013)
Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine KITLG-KIT and IGF1-IG
Externí odkaz:
https://doaj.org/article/6a36f60b865849fca0e540962e4685c9
Autor:
Yujiro Hayashi, David T. Asuzu, Michael R. Bardsley, Gabriella B. Gajdos, Sergiy M. Kvasha, David R. Linden, Rea A. Nagy, Siva Arumugam Saravanaperumal, Sabriya A. Syed, Yoshitaka Toyomasu, Huihuang Yan, Eduardo N. Chini, Simon J. Gibbons, Todd A. Kellogg, Khashayarsha Khazaie, Makoto Kuro-o, Jair Machado Espindola Netto, Mahendra Pal Singh, James G. Tidball, Michelle Wehling-Henricks, Gianrico Farrugia, Tamas Ordog
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Background & Aims: Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to
Externí odkaz:
https://doaj.org/article/8b43f8672b2b4107aadaf0a158051895
Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis
Autor:
Madhusudan Grover, Simon J. Gibbons, Asha A. Nair, Cheryl E. Bernard, Adeel S. Zubair, Seth T. Eisenman, Laura A. Wilson, Laura Miriel, Pankaj J. Pasricha, Henry P. Parkman, Irene Sarosiek, Richard W. McCallum, Kenneth L. Koch, Thomas L. Abell, William J. Snape, Braden Kuo, Robert J. Shulman, Travis J. McKenzie, Todd A. Kellogg, Michael L. Kendrick, James Tonascia, Frank A. Hamilton, Gianrico Farrugia, the NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. Methods Diabetic g
Externí odkaz:
https://doaj.org/article/20e8bd3f92e147689f45774f66978f5d
Autor:
Gianluca Cipriani, Simon J. Gibbons, Pieter-Jan Verhulst, Kyoung Moo Choi, Seth T. Eisenman, Stephanie S. Hein, Tamas Ordog, David R. Linden, Joseph H. Szurszewski, Gianrico Farrugia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 1, Pp 40-47 (2016)
Background & Aims: Diabetic gastroparesis is associated with changes in interstitial cells of Cajal (ICC), neurons, and smooth muscle cells in both animal models and humans. Macrophages appear to be critical to the development of cellular damage that
Externí odkaz:
https://doaj.org/article/2bf9579190304b57859cf3583e6b5d0e
Autor:
Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to g
Autor:
Seth T. Eisenman, Peter R. Strege, Heather L. Holmes, Simon J. Gibbons, Cheryl E. Bernard, Amelia Mazzone, Maria Gabriela Colmenares Aguilar, Gianrico Farrugia, Michael F. Romero
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G93-G107
In this study, we show that the electrogenic Na+/HCO3− cotransporter, NBCe1/Slc4a4, is expressed in subtypes of interstitial cells of Cajal (ICCs) responsible for electrical slow wave generation throughout the mouse gastrointestinal tract and is ab
Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal MotilitySummary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 2, Pp 120-130.e1 (2016)
There is an increasing awareness of the role of macrophages in the regulation and maintenance of gastrointestinal function in health and disease. This work has proceeded in the context of an increased understanding of the complex phenotypic variation
Externí odkaz:
https://doaj.org/article/45b9885afaf445078af93ee80659504f
Autor:
Heidi K. Chua, Vikram Joshi, Gianrico Farrugia, Rondell P. Graham, Constanza Alcaino, Peter R. Strege, Mona El Refaey, Amelia Mazzone, Robert R. Cima, Tamas Ordog, Stefan Calder, Daniel J. Tschumperlin, David W. Larson, Peter J. Mohler, Simon J. Gibbons, Andrew J. Haak, Yujiro Hayashi, Arthur Beyder, Peng Du, Cheryl E. Bernard
Publikováno v:
Gut
ObjectiveThis study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC).DesignAll human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a discovery cohort
Autor:
Gregory O'Grady, Leo K. Cheng, Tim Hsu Han Wang, Timothy R. Angeli, Simon J. Gibbons, Grant Beban, John A. Windsor, Peng Du, Francesca Bianco
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Postsurgical gastric dysfunction is common, but the mechanisms are varied and poorly understood. The pylorus normally acts as an electrical barrier isolating gastric and intestinal slow waves. In this report, we present an aberrant electrical conduct