Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Simon J F, Macdonald"'
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Publikováno v:
Nature Reviews. Drug Discovery
Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec92279a6333adbcbbb9fa28d8e0c4b8
https://doi.org/10.1038/s41573-021-00284-4
https://doi.org/10.1038/s41573-021-00284-4
Autor:
Jennifer M. Clark, Fernando Salgado-Polo, Simon J. F. Macdonald, Tim N. Barrett, Anastassis Perrakis, Craig Jamieson
Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can lead to the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb65acde0750fd7323d1ce9b5b2095b
https://strathprints.strath.ac.uk/80159/7/Clark_etal_JMC_2022_Structure_based_design_of_a_novel_class_of_autotaxin_inhibitors.pdf
https://strathprints.strath.ac.uk/80159/7/Clark_etal_JMC_2022_Structure_based_design_of_a_novel_class_of_autotaxin_inhibitors.pdf
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4959cf67302e9783a88dddd530b0b
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Publikováno v:
Journal of Chemical Information and Modeling. 60:5487-5498
The urgent need for new treatments for the chronic lung disease idiopathic pulmonary fibrosis (IPF) motivates research into antagonists of the RGD binding integrin αvβ6, a protein linked to the initiation and progression of the disease. Molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c245da99eb1232eb54e1011b1e057db0
https://doi.org/10.1021/acs.jcim.0c00254
https://doi.org/10.1021/acs.jcim.0c00254
Publikováno v:
Organic & Biomolecular Chemistry. 18:6696-6701
Iridium-catalysed catalytic, regioselective C–H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376e265aa5dd5fadc2188b600e03164b
https://doi.org/10.1039/d0ob01495h
https://doi.org/10.1039/d0ob01495h
Autor:
Richard J. D. Hatley, Steve P. McLachlan, Kathleen Baster, Lucy C. Gelder, Simon J. F. Macdonald
Publikováno v:
Journal of medicinal chemistry. 65(1)
A bibliometric study of authors across medicinal chemistry journals over 20 years reveals important trends. Most United States (US) based authors are assigned as racially/ethnically Asian or White; few are Black or Hispanic. More US coauthors have th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e19ac2526cc025b0dc35c3e47bec02e
https://pubmed.ncbi.nlm.nih.gov/34931848
https://pubmed.ncbi.nlm.nih.gov/34931848
Autor:
Panayiotis A. Procopiou, Simon J. F. Macdonald, Ben S. Barksby, Jeni Luckett, Richard P. Marshall, Yim Man, Valerie S. Morrison, Lee A. Borthwick, Alex L Wilkinson, R. Gisli Jenkins, Elaine Gower, Rory Barnes, Alison E. John, Richard J. D. Hatley, John Barrett, K. Tao Pun, James A. Roper, Tim N. Barrett, Andrew J. Fisher, Robert J. Slack, Rachel A. Burgoyne
Publikováno v:
European journal of pharmacology. 913
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β (TGFβ) via the alpha-V beta-6 (αvβ6) integrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab5aeaeda70ec0b5bdd8dacee1a7937
https://pubmed.ncbi.nlm.nih.gov/34762934
https://pubmed.ncbi.nlm.nih.gov/34762934
Autor:
Simon J F, Macdonald, Geoffrey D E, Clarke, Michael D, Dowle, Lee A, Harrison, Simon T, Hodgson, Graham G A, Inglis, Martin R, Johnson, Prit, Shah, Richard J, Upton, Steven B, Walls
Publikováno v:
The Journal of organic chemistry. 64(14)
A flexible, practical, and stereoselective synthesis of enantiomerically pure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd9b13ef74f72d85e684fd8ce230d565
https://pubmed.ncbi.nlm.nih.gov/34237863
https://pubmed.ncbi.nlm.nih.gov/34237863
Autor:
Harley Green, Lydia Barnes, Jolyon Matthews-Wright, Rachel Szpara, Luke Francis, Nuria S. Lima, Hollie Blaber, Carrie K. W. Wong, Alexander Seal, Charlotte S. Payne, Matthew F. Meehan, C. Elizabeth Killalea, Rohan J. Trainor, Katherine Wood, Jack M. J. Grace, Oliver Williams, Liam Cochrane, Edmund J. P. Hogarth, Katherine Louise Jones, Zoe J. Lee, Shusha Mahdy, Anna Gruszka, Lisa Morrison, Freya Taday, Leyla Jusu, Oliver King, May-Li Mackinnon, Joe Stillibrand, Daniel Buckley, Edward Cooney, Z.A. Henley, Simon J. F. Macdonald, Christina L. Long, Daniel Fu He, Craig Pike, Zoe C. Byron, Keenan M. Smith, Ian Edward David Smith, Antony M. Threadgould, Lewis Byers, Kamile Stanelyte, Hal R. I. Parke, Nick Barton, Rosa Cookson, James E. Rowedder, Andrew Nortcliffe, Aaron J. Senior, Alan Nadin, Makenzie J. Millward, Joseph Lambert, Lawrence Payne, David T. K. Brooks, Christopher Merrett, Heather A. Damian, Jordan Waters, Richard G. Chilvers
Publikováno v:
Journal of Medicinal Chemistry. 62:10402-10422
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c565e07f6df53b788d687eb5d9b250
https://doi.org/10.1021/acs.jmedchem.9b01499
https://doi.org/10.1021/acs.jmedchem.9b01499