Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Simon J Dovedi"'
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTInnovative approaches in the design of T cell-engaging (TCE) molecules are ushering in a new wave of promising immunotherapies for the treatment of cancer. Their mechanism of action, which generates an in trans interaction to create a synthet
Externí odkaz:
https://doaj.org/article/3e72b1cc99f146d7aaec4efa9cd6c54c
Autor:
Jennifer P Morton, Matthew Wilson, Hannah Buckley, Alwin G Schuller, Richard Goodwin, Kate Williamson, Frances M Richards, Duncan I Jodrell, Saadia A Karim, Simon J Dovedi, Jim Eyles, Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Rebecca Brais
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background The prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. It has been suggested that the adenosine pathway contributes to the ability of PDAC to evade the immune system and hence, its resistance to imm
Externí odkaz:
https://doaj.org/article/f9d832bad08344709ee59ce32bb6e960
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 95-106 (2022)
The field of Immuno-Oncology (IO) is evolving to utilise novel antibody backbones that can co-target multiple cell-surface stimulatory and inhibitory co-receptors (SICR). This approach necessitates a better understanding of SICR co-expression at the
Externí odkaz:
https://doaj.org/article/9087a34ea27f4b3ea19c5bd2348d173a
Autor:
Robert W Wilkinson, Hormas Ghadially, Stacy Kentner, Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Matthew J Robinson, Tim Slidel, Simon J Dovedi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Immuno-oncology therapies are now part of the standard of care for cancer in many indications. However, durable objective responses remain limited to a subset of patients. As such, there is a critical need to identify biomarkers that can p
Externí odkaz:
https://doaj.org/article/0daba65ab2174eb2906d5b3b2486abf0
Autor:
Stefanie R. Mullins, John P. Vasilakos, Katharina Deschler, Iwen Grigsby, Pete Gillis, Julius John, Matthew J. Elder, John Swales, Elina Timosenko, Zachary Cooper, Simon J. Dovedi, Andrew J. Leishman, Nadia Luheshi, James Elvecrog, Ashenafi Tilahun, Richard Goodwin, Ronald Herbst, Mark A. Tomai, Robert W. Wilkinson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically “cold” tumors, tumor-resident innate immune cell activation may be required to
Externí odkaz:
https://doaj.org/article/664a845e229648008b22d687ebf6b261
Autor:
Nadine Nelson, Marta Lopez-Pelaez, Asis Palazon, Edmund Poon, Maike De La Roche, Simon Barry, Viia Valge-Archer, Robert W. Wilkinson, Simon J. Dovedi, Paul D. Smith
Publikováno v:
OncoImmunology, Vol 8, Iss 8, Pp 1-10 (2019)
In vitro assays that evaluate CD8+ T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor immune responses. Here, we describe a novel cytotoxicity co-culture assay that circumvents t
Externí odkaz:
https://doaj.org/article/bef43dac3ea74350878e6dc63b21d270
Autor:
Yuri Kosinsky, Simon J. Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Helen Tomkinson, Nidal Al-Huniti, Donald R. Stanski, Gabriel Helmlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor siz
Externí odkaz:
https://doaj.org/article/6864f2475f1e4703b3c1be9f5fbfb02a
Autor:
Christoph Wülfing, Simon J. Dovedi
Publikováno v:
Nature. 614:416-418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f98416a2f577357d1a351624e507fa
https://doi.org/10.1038/d41586-023-00244-5
https://doi.org/10.1038/d41586-023-00244-5
Autor:
Edmund Poon, Stefanie Mullins, Amanda Watkins, Geoffrey S. Williams, Jens-Oliver Koopmann, Gianfranco Di Genova, Marie Cumberbatch, Margaret Veldman-Jones, Shaun E. Grosskurth, Vasu Sah, Alwin Schuller, Corrine Reimer, Simon J. Dovedi, Paul D. Smith, Ross Stewart, Robert W. Wilkinson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-14 (2017)
Abstract Background T-cell checkpoint blockade and MEK inhibitor combinations are under clinical investigation. Despite progress elucidating the immuno-modulatory effects of MEK inhibitors as standalone therapies, the impact of MEK inhibition on the
Externí odkaz:
https://doaj.org/article/10af9c0a04c24ff1aad8329f36522589
Small gene networks delineate immune cell states and characterize immunotherapy response in melanoma
Autor:
Donagh Egan, Martina Kreileder, Myriam Nabhan, Luis F. Iglesias-Martinez, Simon J. Dovedi, Viia Valge-Archer, Amit Grover, Robert W. Wilkinson, Timothy Slidel, Claus Bendtsen, Ian P. Barrett, Donal J. Brennan, Walter Kolch, Vadim Zhernovkov
Publikováno v:
Cancer Immunology Research.
Single-cell technologies have elucidated mechanisms responsible for immune checkpoint inhibitor (ICI) response, but are not amenable to a clinical diagnostic setting. In contrast, bulk RNA sequencing (RNA-seq) is now routine for research and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f30e1b90aa882bd0665bee0abe8a62f
https://doi.org/10.1158/2326-6066.cir-22-0563
https://doi.org/10.1158/2326-6066.cir-22-0563