Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon J Carter"'
Autor:
Ferran Gonzalez Hernandez, Simon J Carter, Juha Iso-Sipilä, Paul Goldsmith, Ahmed A. Almousa, Silke Gastine, Watjana Lilaonitkul, Frank Kloprogge, Joseph F Standing
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Pharmacokinetic (PK) predictions of new chemical entities are aided by prior knowledge from other compounds. The development of robust algorithms that improve preclinical and clinical phases of drug development remains constrained by the need to sear
Externí odkaz:
https://doaj.org/article/2eb00f5a5852475b9bff6607a3802d01
Autor:
Xiaomei Chen, Rikard Nordgren, Stella Belin, Alzahra Hamdan, Shijun Wang, Tianwu Yang, Zhe Huang, Simon J. Carter, Simon Buatois, João A. Abrantes, Andrew C. Hooker, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1784-1797 (2024)
Abstract Population pharmacokinetic (PK) models are widely used to inform drug development by pharmaceutical companies and facilitate drug evaluation by regulatory agencies. Developing a population PK model is a multi‐step, challenging, and time‐
Externí odkaz:
https://doaj.org/article/7b021a7f7b66484a8b7f9eaa81834ea5
Autor:
Robert S Phillips, Bryonnie Scott, Simon J Carter, Matthew Taylor, Eleanor Peirce, Patrick Davies, Ian K Maconochie
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130327 (2015)
BackgroundCardiopulmonary arrest in children is an uncommon event, and often fatal. Resuscitation is often attempted, but at what point, and under what circumstances do continued attempts to re-establish circulation become futile? The uncertainty aro
Externí odkaz:
https://doaj.org/article/9e3373fe23b345be904c5100fe53f1f7
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 4, Pp 211-221 (2020)
A structurally identifiable micro‐rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goodness‐of‐fit values through comeasurement of pitavastatin and eltrombopag. Transporter
Externí odkaz:
https://doaj.org/article/a5f53b308f794671b966c68b6dd7040b
Autor:
Frank Kloprogge, Simon J Carter, Judith Breuer, Joseph F. Standing, Florencia A.T. Boshier, Ivan Hung, Dagan O. Lonsdale, Mario Cortina-Borja, Juanita Pang, Silke Gastine
Publikováno v:
Clinical Pharmacology and Therapeutics
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral loads change rapidly following symptom onset, so to assess antivirals it is important to understand the natural history and patient factors influencing this. We undertook an individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d18ad6aaa7b796ba5f0ffa6d5e448
https://doi.org/10.1002/cpt.2223
https://doi.org/10.1002/cpt.2223
Autor:
Karelle Ménochet, Lloyd M. King, Alex S. Ferecskó, Michael J. Chappell, Ted Parton, Simon J. Carter
Publikováno v:
Xenobiotica. 50:415-426
Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method.Atorvastatin was incu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ac841fe46e409c23b09622555095e3
https://doi.org/10.1080/00498254.2019.1652781
https://doi.org/10.1080/00498254.2019.1652781
Autor:
Frank Kloprogge, Ferran Gonzalez Hernandez, Juha Iso-Sipilä, Ahmed A Almousa, Paul Goldsmith, Joseph F. Standing, Silke Gastine, Simon J Carter, Watjana Lilaonitkul
Publikováno v:
Wellcome Open Research
Pharmacokinetic (PK) predictions of new chemical entities are aided by prior knowledge from other compounds. The development of robust algorithms that improve preclinical and clinical phases of drug development remains constrained by the need to sear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0f7d3a1461fc14af6c6f2fd240158a
https://pubmed.ncbi.nlm.nih.gov/34381873
https://pubmed.ncbi.nlm.nih.gov/34381873
Autor:
Frank Kloprogge, Silke Gastine, Simon J Carter, Mario Cortina-Borja, Ivan Hung, Florencia A.T. Boshier, Judith Breuer, Dagan O. Lonsdale, Joseph F. Standing, Juanita Pang
SUMMARY Background SARS-CoV-2 viral loads change rapidly following symptom onset so to assess antivirals it is important to understand the natural history and patient factors influencing this. We undertook an individual patient-level meta-analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7ed5a4f699e2d28cad286877cb4f4c
https://doi.org/10.1101/2020.08.20.20178699
https://doi.org/10.1101/2020.08.20.20178699
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 4, Pp 211-221 (2020)
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 4, Pp 211-221 (2020)
A structurally identifiable micro‐rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goodness‐of‐fit values through comeasurement of pitavastatin and eltrombopag. Transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fa7a7a96312ab3f65c53bcf4167a34
https://pubmed.ncbi.nlm.nih.gov/32142598
https://pubmed.ncbi.nlm.nih.gov/32142598
Autor:
Eleanor Peirce, Simon J. Carter, Matthew Taylor, Bryonnie Scott, Patrick Davies, Ian Maconochie, Robert S. Phillips
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0130327 (2015)
PLoS ONE, Vol 10, Iss 6, p e0130327 (2015)
BackgroundCardiopulmonary arrest in children is an uncommon event, and often fatal. Resuscitation is often attempted, but at what point, and under what circumstances do continued attempts to re-establish circulation become futile? The uncertainty aro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d55ef5ca4051bf488f47a8c22b7cf6c
https://pubmed.ncbi.nlm.nih.gov/26107958
https://pubmed.ncbi.nlm.nih.gov/26107958