Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Simon J Boulton"'
Autor:
Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010025 (2022)
Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular
Externí odkaz:
https://doaj.org/article/a96ac9391b0141f5855e9de298dde95f
Autor:
Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl
Publikováno v:
eLife, Vol 10 (2021)
The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss con
Externí odkaz:
https://doaj.org/article/f3f3bd2076484817a1cc27acc9027411
Autor:
Bari J Ballew, Vijai Joseph, Saurav De, Grzegorz Sarek, Jean-Baptiste Vannier, Travis Stracker, Kasmintan A Schrader, Trudy N Small, Richard O'Reilly, Chris Manschreck, Megan M Harlan Fleischut, Liying Zhang, John Sullivan, Kelly Stratton, Meredith Yeager, Kevin Jacobs, Neelam Giri, Blanche P Alter, Joseph Boland, Laurie Burdett, Kenneth Offit, Simon J Boulton, Sharon A Savage, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003695 (2013)
Dyskeratosis congenita (DC) is a heterogeneous inherited bone marrow failure and cancer predisposition syndrome in which germline mutations in telomere biology genes account for approximately one-half of known families. Hoyeraal Hreidarsson syndrome
Externí odkaz:
https://doaj.org/article/8227b26c0dbc4b9aa78d97185bee92cb
Autor:
Nigel J O'Neil, Julie S Martin, Jillian L Youds, Jordan D Ward, Mark I R Petalcorin, Anne M Rose, Simon J Boulton
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003582 (2013)
The generation and resolution of joint molecule recombination intermediates is required to ensure bipolar chromosome segregation during meiosis. During wild type meiosis in Caenorhabditis elegans, SPO-11-generated double stranded breaks are resolved
Externí odkaz:
https://doaj.org/article/370aa933cc4c4013a58fa02ba8b07e8c
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000735 (2009)
Homologous recombination (HR) is essential for the repair of blocked or collapsed replication forks and for the production of crossovers between homologs that promote accurate meiotic chromosome segregation. Here, we identify HIM-18, an ortholog of M
Externí odkaz:
https://doaj.org/article/123c1754bbe94ad89733b63f929ffcae
Autor:
Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human i
Externí odkaz:
https://doaj.org/article/dd8f26a91a1646ca8fb84eb2c02762b3
Autor:
Artur P. Kaczmarczyk, Anne-Cécile Déclais, Matthew D. Newton, Simon J. Boulton, David M. J. Lilley, David S. Rueda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Locating a four-way junction in a high background of genomic DNA is likely to be the rate-limiting step of the resolution process. This study captures the entire reaction trajectory of a nuclease targeting and resolving a DNA junction at single-molec
Externí odkaz:
https://doaj.org/article/2dd4af52a38d41b19aa03fd0a1d451ee
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into
Externí odkaz:
https://doaj.org/article/9694c15ea6ff49a7afe36d07b4947267
Autor:
Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, Femke de Vrij, Steven A. Kushner, Graeme C.M. Smith, Simon J. Boulton, Marcel Tijsterman
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112019- (2023)
Summary: Gene editing through repair of CRISPR-Cas9-induced chromosomal breaks offers a means to correct a wide range of genetic defects. Directing repair to produce desirable outcomes by modulating DNA repair pathways holds considerable promise to i
Externí odkaz:
https://doaj.org/article/2cda6fc70a1649d382e75e95931d82e5
Autor:
Geoff S. Higgins, Helen M.R. Robinson, Graeme C.M. Smith, Robert A. Heald, Ester M. Hammond, Simon J. Boulton, Martin L. Stockley, Eeson Rajendra, Desiree Piscitello, Jayesh B. Majithiya, Vera Grinkevich, Diego Grande, Alessandro Galbiati, Alessandro Cicconi, Aurora Cerutti, Marie Boursier, Daniel Ebner, Val Millar, Hannah R. Bolland, Nicole Machado, Rathi Puliyadi, Remko Prevo, Marco Ranzani, Gonzalo Rodriguez-Berriguete
Accompanies Figure 3 (Effect of ART558 under hypoxic conditions)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78beef4f4c5fd7b17ac4512774531dee
https://doi.org/10.1158/1078-0432.22633127.v1
https://doi.org/10.1158/1078-0432.22633127.v1