Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Simon J, Webb"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0f415f613814406aa70934955dbf2155
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Molecular biology achieves control over complex reaction networks by means of molecular systems that translate a chemical input (such as ligand binding) into an orthogonal chemical output (such as acylation or phosphorylation). We present an
Externí odkaz:
https://doaj.org/article/87f1d19e01b74c12baba99b83d9d6b2e
Autor:
Dr. Natasha Eccles, Dr. Flavio della Sala, Dr. Bryden A. F. Le Bailly, Dr. George F. S. Whitehead, Prof. Jonathan Clayden, Dr. Simon J. Webb
Publikováno v:
ChemistryOpen, Vol 9, Iss 3, Pp 338-345 (2020)
Abstract Two α‐aminoisobutyric acid (Aib) foldamers bearing Zn(II)‐chelating N‐termini have been synthesized and compared with a reported Aib foldamer that has a bis(quinolinyl)/mono(pyridyl) cap (BQPA group). Replacement of the quinolinyl arm
Externí odkaz:
https://doaj.org/article/e32f05420de04e728089c033c321a052
Autor:
Catriona McCallion, Anna D. Peters, Andrew Booth, Karen Rees-Unwin, Julie Adams, Raisa Rahi, Alain Pluen, Claire V. Hutchinson, Simon J. Webb, John Burthem
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2069-2081 (2019)
Abstract: CXC chemokine receptor 4 (CXCR4) is overexpressed by a broad range of hematological disorders, and its interaction with CXC chemokine ligand 12 (CXCL12) is of central importance in the retention and chemoprotection of neoplastic cells in th
Externí odkaz:
https://doaj.org/article/2507d194e7a244fc8e6f2e80527f29d0
Autor:
Matthew Cummings, Anna D Peters, George F S Whitehead, Binuraj R K Menon, Jason Micklefield, Simon J Webb, Eriko Takano
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000347 (2019)
Polyketides are a class of specialised metabolites synthesised by both eukaryotes and prokaryotes. These chemically and structurally diverse molecules are heavily used in the clinic and include frontline antimicrobial and anticancer drugs such as ery
Externí odkaz:
https://doaj.org/article/970f16e4234c437a914e36237aa60a9b
Autor:
Siyuan, Wang, Flavio, Della Sala, Matthew J, Cliff, George F S, Whitehead, Iñigo J, Vitórica-Yrezábal, Simon J, Webb
Publikováno v:
Journal of the American Chemical Society. 144(47)
Understanding and controlling peptide foldamer conformation in phospholipid bilayers is a key step toward their use as molecular information relays in membranes. To this end, a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32f844d674693f4a2f8a29c97f27cd81
https://pubmed.ncbi.nlm.nih.gov/36379007
https://pubmed.ncbi.nlm.nih.gov/36379007
Autor:
Joana Silva, Reynard Spiess, Andrea Marchesi, Sabine L. Flitsch, Julie E. Gough, Simon J. Webb
Publikováno v:
Silva, J, Spiess, R, Marchesi, A, Flitsch, S L, Gough, J & Webb, S 2022, ' Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes ', Journal of Materials Chemistry B . https://doi.org/10.1039/D2TB00714B
Oxime formation is a convenient one-step method for ligating reducing sugars to surfaces, producing a mixture of closed ring α- and β-anomers along with open-chain (E)- and (Z)-isomers. Here we show that despite existing as a mixture of isomers, N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b65c94ca982799831cb1568e5b6ac3
https://pubmed.ncbi.nlm.nih.gov/35723603
https://pubmed.ncbi.nlm.nih.gov/35723603
Publikováno v:
Chivers, P R A, Dookie, R S, Gough, J & Webb, S 2020, ' Photo-dissociation of self-assembled (anthracene-2-carbonyl)amino acid hydrogels ', Chemical Communications . https://doi.org/10.1039/D0CC05292B
Amino acids modified with an N-terminal anthracene group self-assemble into supramolecular hydrogels upon the addition of a range of salts or cell culture medium. Gel-phase photo-dimerisation of gelators results in hydrogel disassembly and was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fe8453d8b6ca15c29515f88dc3a71d
https://doi.org/10.1039/d0cc05292b
https://doi.org/10.1039/d0cc05292b
Autor:
David P. Tilly, William Cullen, Heng Zhong, Romain Jamagne, Inigo Vitórica‐Yrezábal, Simon J. Webb
Publikováno v:
Tilly, D P, Cullen, W, Zhong, H, Jamagne, R, Vitórica-yrezábal, I & Webb, S J 2022, ' α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202104293
To investigate how remotely induced changes in ligand folding might affect catalysis by organometallic complexes, dynamic α-amino-iso-butyric acid (Aib) peptide foldamers bearing rhodium(I) N-heterocyclic carbene (NHC) complexes have been synthesise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdf1ae6bacfefff1fe4f40a91bb866a
https://doi.org/10.1002/chem.202104293
https://doi.org/10.1002/chem.202104293
Autor:
Robert Šardzík, Gavin T. Noble, Martin J. Weissenborn, Andrew Martin, Simon J. Webb, Sabine L. Flitsch
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 699-703 (2010)
The synthesis of a number of aminoethyl glycosides of cell-surface carbohydrates, which are important intermediates for glycoarray synthesis, is described. A set of protocols was developed which provide these intermediates, in a short number of steps
Externí odkaz:
https://doaj.org/article/bb2d26b91a944e6fad871952ddf99b0d