Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Simon Hoffenberg"'
Autor:
Ross W. B. Lindsay, Ivo C. Lorenz, Jaap Willem Back, Gavin Morrow, Christy Jurgens, Sanjay Phogat, Hanh T. Nguyen, Joanne DeStefano, Heather Arendt, Christopher L. Parks, Kevin J. Wright, Maoli Yuan, M Kemelman, Simon Hoffenberg, Timothy J. Zamb
Publikováno v:
AIDS Research and Human Retroviruses. 30:1130-1144
The structure of the HIV-1 envelope membrane-proximal external region (MPER) is influenced by its association with the lipid bilayer on the surface of virus particles and infected cells. To develop a replicating vaccine vector displaying MPER sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e9c57711f3b67f8f0fa9361e0d546f
https://doi.org/10.1089/aid.2013.0206
https://doi.org/10.1089/aid.2013.0206
Autor:
Albert Cupo, Jeong Hyun Lee, Ronald Derking, Michael J. Caulfield, Andre J. Marozsan, Simon Hoffenberg, C. Richter King, Rogier W. Sanders, John P. Moore, Per Johan Klasse, Andrew B. Ward, Charles D. Murin, Ian A. Wilson, Jean-Philippe Julien
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 110(11), 213-218. National Academy of Sciences
PG9 is the founder member of an expanding family of glycan-dependent human antibodies that preferentially bind the HIV (HIV-1) envelope (Env) glycoprotein (gp) trimer and broadly neutralize the virus. Here, we show that a soluble SOSIP.664 gp140 trim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ea5af950dbb30681453a1480e90f06
https://doi.org/10.1073/pnas.1217537110
https://doi.org/10.1073/pnas.1217537110
Autor:
Fred Shiau, Patrick Liu, Antonio Ortiz-Buijsse, Louis Boon, Simon Hoffenberg, Jon D. Laman, Mark de Boer, Marcel T. den Hartog
Publikováno v:
Toxicology. 174:53-65
Monoclonal antibody (Mab) 5D12 is a potent antagonist of the CD40-CD40L pathway. This cellular interaction has been validated in a large number of experimental animal models where dys-regulation of the immune system plays a role. Chimeric 5D12 (ch5D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad5bf9edb6d347a4695aa750c49cfa0
https://doi.org/10.1016/s0300-483x(02)00057-4
https://doi.org/10.1016/s0300-483x(02)00057-4
Autor:
Kizhake V. Soman, Burton F. Dickey, Simon Hoffenberg, D. Sundarsingh Daniel, Jeffry C. Nichols, Lydia Nikolova
Publikováno v:
Biochemical Journal. 336:461-469
Tryptic proteolysis of the small GTPases Rab4 and Rab5 is a multi-step, nucleotide-dependent process. Using N-terminal peptide sequencing, matrix-assisted laser desorption ionization–time-of-flight MS and molecular modelling, we identified the thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2e483d4e24b5a0f4d9d18def72b0ce
https://doi.org/10.1042/bj3360461
https://doi.org/10.1042/bj3360461
Autor:
Ross W. B. Lindsay, Simon Hoffenberg, Aaron J. Wilson, Rebecca L.R. Powell, Michael J. Caulfield, Alexei Carpov, Svetlana Rabinovich
A new generation of extremely broad and potent neutralizing antibodies (bNAbs) has been isolated from HIV-infected subjects. This has refocused interest in the sites of vulnerability targeted by these bNAbs and in the potential for designing Envelope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23801ed953409192578356f0270f9ea
https://europepmc.org/articles/PMC3653378/
https://europepmc.org/articles/PMC3653378/
Autor:
Pham Phung, Steven P. Fling, Heather Arendt, Melissa Simek, Wayne C. Koff, Aaron J. Wilson, David C. Montefiori, Pascal Poignard, Rebecca L.R. Powell, Alexei Carpov, Christopher L. Parks, Michael J. Caulfield, Denise Wagner, Simon Hoffenberg, C. Richter King, Sanjay Phogat, Terri Wrin, Sergei L. Kosakovsky Pond, Celia C. LaBranche, Joanne DeStefano, Ross W. B. Lindsay, Dennis R. Burton
Publikováno v:
Journal of virology. 87(10)
Broadly neutralizing antibodies (bNAbs) PG9 and PG16 were isolated from an International AIDS Vaccine Initiative (IAVI) Protocol G subject infected with human immunodeficiency virus type 1 (HIV-1) clade A. Both antibodies are highly potent and neutra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6109334f7131d9c3393e92960e7e3b
https://pubmed.ncbi.nlm.nih.gov/23468492
https://pubmed.ncbi.nlm.nih.gov/23468492
Autor:
P. Woodford, N. D. V. Carsrud, Simon Hoffenberg, Robert H. Moore, Burton F. Dickey, JoAnn Trial, Brian J. Knoll, K. Angelides, Nicholas Sadovnikoff, Shaobin Liu
Publikováno v:
Journal of Cell Science. 108:2983-2991
The small GTPase rab5 appears to be rate-limiting for the constitutive internalization of transferrin receptor and for fluid-phase endocytosis. However, it is unknown whether rab5 regulates receptors whose internalization is stimulated by the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae139dfa5b2609ef1fd84c51a65f473a
https://doi.org/10.1242/jcs.108.9.2983
https://doi.org/10.1242/jcs.108.9.2983
Autor:
Jack C. Sanford, Marianne Wessling-Resnick, Shaobin Liu, D. Sundarsingh Daniel, Simon Hoffenberg, Burton F. Dickey, Michael Tuvin, Brian J. Knoll
Publikováno v:
Journal of Biological Chemistry. 270:5048-5056
Biochemical, structural, and functional properties of Rab5 wild-type (WT) protein were compared with those of Q79L and N133I mutants. The detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate increased guanine nucleotide binding to Rab5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21791d710639ac969f332f2b701119d
https://doi.org/10.1074/jbc.270.10.5048
https://doi.org/10.1074/jbc.270.10.5048
Autor:
Ten Feizi, Andrew B. Ward, Henry Tien, Dennis R. Burton, Jean-Philippe Julien, Simon Hoffenberg, Marc C. Deller, Albert Cupo, James C. Paulson, Charles D. Murin, Yan Liu, Andre J. Marozsan, Yuanzi Hua, Katie J. Doores, Michael J. Caulfield, Leopold Kong, Ian A. Wilson, Ryan McBride, Per Johan Klasse, John P. Moore, Rogier W. Sanders, Jeong Hyun Lee, Thomas Clayton, Robyn L. Stanfield, Reza Khayat, Khoa Le, C. Richter King
Publikováno v:
Nature structural & molecular biology
Nature structural & molecular biology, 20(7), 796-+. Nature Publishing Group
Nature structural & molecular biology, 20(7), 796-+. Nature Publishing Group
A substantial proportion of the broadly neutralizing antibodies (bnAbs) identified in certain HIV-infected donors recognize glycan-dependent epitopes on HIV-1 gp120. Here we elucidate how the bnAb PGT 135 binds its Asn332 glycan-dependent epitope fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc33ace59788c2f93b530895a67cb2
https://pubmed.ncbi.nlm.nih.gov/23984441
https://pubmed.ncbi.nlm.nih.gov/23984441
Autor:
Perry J. Tiberio, CR King, Christopher L. Parks, Michael J. Caulfield, Aaron J. Wilson, M Kemelman, Sanjay Phogat, Christy Jurgens, Maoli Yuan, Kevin J. Wright, Simon Hoffenberg, Ivo C. Lorenz, Cesar Boggiano
Publikováno v:
Retrovirology
Methods Using a combination of nucleotide sequence optimization and protein domain swapping, we have generated a panel of novel gene inserts for VSV vectors that encode chimeric HIV-1 and VSV glycoprotein immunogens (EnvG). A stable VERO cell line en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90eaa380539c14796d3d80646e58035
https://doi.org/10.1186/1742-4690-9-s2-p342
https://doi.org/10.1186/1742-4690-9-s2-p342