Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Simon Hebeisen"'
1
Akademický článek
Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study
Autor: Annie Delaunois, François‐Xavier Mathy, Miranda Cornet, Vitalina Gryshkova, Chloé Korlowski, François Bonfitto, Juliane Koch, Anne‐Françoise Schlit, Simon Hebeisen, Elisa Passini, Blanca Rodriguez, Jean‐Pierre Valentin
Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Levetiracetam (LEV), a well‐established anti‐seizure medication (ASM), was launched before the original ICH S7B nonclinical guidance assessing QT prolongation potential and the introduction of the Comprehensive In Vitro Proarrhythmia Ass
Externí odkaz: https://doaj.org/article/8e3d0b97aa3843f1ab02c7d3ae9a2afc
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2
Akademický článek
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
Autor: Annie Delaunois, Matthew Abernathy, Warren D. Anderson, Kylie A. Beattie, Khuram W. Chaudhary, Julie Coulot, Vitalina Gryshkova, Simon Hebeisen, Mark Holbrook, James Kramer, Yuri Kuryshev, Derek Leishman, Isabel Lushbough, Elisa Passini, Will S. Redfern, Blanca Rodriguez, Eric I. Rossman, Cristian Trovato, Caiyun Wu, Jean‐Pierre Valentin
Publikováno v: Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Abstract We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsade
Externí odkaz: https://doaj.org/article/d703d6568c29415c8e2d93ccf47af5d0
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5
Applying the CiPA Approach to Evaluate Cardiac Proarrhythmia Risk of some Antimalarials Used Off‐label in the First Wave of COVID‐19
Autor: Isabel Lushbough, Jean-Pierre Valentin, Vitalina Gryshkova, Simon Hebeisen, Cristian Trovato, Will S. Redfern, Khuram W. Chaudhary, Caiyun Wu, Eric I. Rossman, Kylie A. Beattie, Julie Coulot, Elisa Passini, Yuri A. Kuryshev, Warren D. Anderson, Blanca Rodriguez, Annie Delaunois, Derek J. Leishman, Matthew M. Abernathy, James Kramer, Mark Holbrook
Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
We applied a set of in silico and in vitro assays, compliant with the CiPA (Comprehensive In Vitro Proarrhythmia Assay) paradigm, to assess the risk of chloroquine or hydroxychloroquine‐mediated QT prolongation and Torsades de Pointes (TdP), alone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ff6229742ba87f71f81a342b9f06c
http://europepmc.org/articles/PMC8014548
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7
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm
Autor: Nadine Becker, Mohammadreza Samieegohar, John Imredy, Jin Zhai, Anders Lindqvist, Søren Friis, Nina Brinkwirth, Tim Strassmaier, Jae Kwagh, James Kramer, Jingsong Fan, Paul Levesque, Sonja Stoelzle-Feix, Bradley J. Ridder, Herbert Himmel, Timm Danker, Derek J. Leishman, Markus Rapedius, Liudmila Polonchuk, Jiansong Sheng, Marc Rogers, Gary R. Mirams, Simon Hebeisen, Haiyang Wei, George Okeyo, Evgenia Gissinger, Tom A. Goetze, Phu N. Tran, Zhihua Li, Rémi Bardenet, Yuri A. Kuryshev, Muthukrishnan Renganathan, Maria Giustina Rotordam, Aaron Randolph, Daniel Konrad, Robert W. Kirby, Wendy W. Wu, Caiyun Wu, David G. Strauss, Matthew Bridgland-Taylor, Bryan Koci, Edward Humphries, Xiaomei Han
Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Introduction hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantificatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e258ca318d261e63e5e97ce793630
http://europepmc.org/articles/PMC7166077
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8
Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells
Autor: Patrício Soares-da-Silva, Thoralf Opitz, Dominik Holtkamp, Simon Hebeisen, Heinz Beck
Publikováno v: Epilepsia. 59:1492-1506
Objective Pharmacoresistance is a problem affecting ∼30% of chronic epilepsy patients. An understanding of the mechanisms of pharmacoresistance requires a precise understanding of how antiepileptic drugs interact with their targets in control and e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364b3b1ba32f9c72c02c134e6fbe4cf0
https://doi.org/10.1111/epi.14504
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10
A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin
Autor: Anne Maier, Veronika Butterweck, Maria Teresa Faleschini, Matthias Hamburger, Simon Hebeisen, Katharina Thasis, Sarah Fankhauser
Publikováno v: Planta medica. 85(11-12)
A fluorometric imaging plate reader (FLIPR) assay utilizing Chinese hamster ovary (CHO) cells stably transfected with GABAA receptors of α 1 β 2 γ 2 subunit composition was evaluated and validated for rapid screening of plant extract libraries and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7625b113c7734c30e3f316a30b5cd5d1
https://pubmed.ncbi.nlm.nih.gov/31127604
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