Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Simon Hauri"'
Autor:
Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus py
Externí odkaz:
https://doaj.org/article/5e6b3b9bfaf4481895310369f23b17c5
Autor:
M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex a
Externí odkaz:
https://doaj.org/article/6895486193a040a6ada179998498e708
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from
Externí odkaz:
https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d
Autor:
Martin R Edelmann, Simon Hauri
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257342 (2021)
Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in utilizing labelled therapeutic antibodies is that the label has no unfavourable effects on an
Externí odkaz:
https://doaj.org/article/315633afb252420586c82ff217f61f6b
Autor:
Maria Jassinskaja, Emil Johansson, Trine Ahn Kristiansen, Hugo Åkerstrand, Kristoffer Sjöholm, Simon Hauri, Johan Malmström, Joan Yuan, Jenny Hansson
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3285-3297 (2017)
Hematopoietic stem and progenitor cells (HSPCs) in the fetus and adult possess distinct molecular landscapes that regulate cell fate and change their susceptibility to initiation and progression of hematopoietic malignancies. Here, we applied in-dept
Externí odkaz:
https://doaj.org/article/f4ba9aaa9a5e4bedbf2385c9b2d2c359
Autor:
Simon Hauri, Federico Comoglio, Makiko Seimiya, Moritz Gerstung, Timo Glatter, Klaus Hansen, Ruedi Aebersold, Renato Paro, Matthias Gstaiger, Christian Beisel
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 583-595 (2016)
Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome using a robust affinity purification mass spectrometry approach. Our high-densi
Externí odkaz:
https://doaj.org/article/217365dd42f14af0a94ab1a25cec3cce
Autor:
Erik Malmström, Ola Kilsgård, Simon Hauri, Emanuel Smeds, Heiko Herwald, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Sepsis can lead to multiple organ failure that could potentially be reflected by change in plasma protein abundance. Here the authors describe a proteomics strategy that allows the determination of plasma proteins tissue origin in a quantitative mann
Externí odkaz:
https://doaj.org/article/180515b4471648a094ca8757685ed496
Autor:
Simon Hauri, Paulina Jakubiak, Matthias Fueth, Stefan Dengl, Sara Belli, Rubén Alvarez-Sánchez, Antonello Caruso
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 810 (2020)
The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the ocular half-life in rabbits, however, the underlying mo
Externí odkaz:
https://doaj.org/article/2423a8e975de4e188560c9ef798fb2e5
Autor:
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon
Publikováno v:
eLife, Vol 6 (2017)
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. th
Externí odkaz:
https://doaj.org/article/b1c33b3864b7463aa607b906588ff5c7
Autor:
Simon Hauri, Alexander Wepf, Audrey van Drogen, Markku Varjosalo, Nic Tapon, Ruedi Aebersold, Matthias Gstaiger
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-16 (2013)
Abstract Tissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell growth and cell shape upon changes in the cellular environment. Deregulation of these processes is associated with human cancer and can occur at m
Externí odkaz:
https://doaj.org/article/6309dc071d53472095ea29758789363f