Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Simon Haile"'
Autor:
Jing Xu, Pawan K Pandoh, Richard D Corbett, Duane Smailus, Reanne Bowlby, Denise Brooks, Helen McDonald, Simon Haile, Sundeep Chahal, Steve Bilobram, Karen L Mungall, Andrew J Mungall, Robin Coope, Richard A Moore, Yongjun Zhao, Steven JM Jones, Marco A Marra
Publikováno v:
BioTechniques, Vol 75, Iss 2, Pp 47-55 (2023)
High-throughput total nucleic acid (TNA) purification methods based on solid-phase reversible immobilization (SPRI) beads produce TNA suitable for both genomic and transcriptomic applications. Even so, small RNA species, including miRNA, bind weakly
Externí odkaz:
https://doaj.org/article/320fbed6e6e54c1996d0d06202133dd1
Autor:
Simon Haile, Richard D. Corbett, Veronique G. LeBlanc, Lisa Wei, Stephen Pleasance, Steve Bilobram, Ka Ming Nip, Kirstin Brown, Eva Trinh, Jillian Smith, Diane L. Trinh, Miruna Bala, Eric Chuah, Robin J. N. Coope, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Yongjun Zhao, Martin Hirst, Samuel Aparicio, Inanc Birol, Steven J. M. Jones, Marco A. Marra
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
RNA sequencing (RNAseq) has been widely used to generate bulk gene expression measurements collected from pools of cells. Only relatively recently have single-cell RNAseq (scRNAseq) methods provided opportunities for gene expression analyses at the s
Externí odkaz:
https://doaj.org/article/64eb43c6a0f04391b354df5ccac16ee4
Autor:
Pawan K Pandoh, Richard D Corbett, Helen McDonald, Miguel Alcaide, Heather Kirk, Eva Trinh, Simon Haile, Tina MacLeod, Duane Smailus, Steve Bilobram, Andrew J Mungall, Yussanne Ma, Richard A Moore, Robin Coope, Yongjun Zhao, Steven JM Jones, Robert A Holt, Aly Karsan, Ryan D Morin, Marco A Marra
Publikováno v:
BioTechniques, Vol 66, Iss 2, Pp 85-92 (2019)
The analysis of cell-free circulating tumor DNA (ctDNA) is potentially a less invasive, more dynamic assessment of cancer progression and treatment response than characterizing solid tumor biopsies. Standard isolation methods require separation of pl
Externí odkaz:
https://doaj.org/article/f8f9577ca3a1407898403489370a3edf
Autor:
Simon Haile, Richard D. Corbett, Tina MacLeod, Steve Bilobram, Duane Smailus, Philip Tsao, Heather Kirk, Helen McDonald, Pawan Pandoh, Miruna Bala, Martin Hirst, Diane Miller, Richard A. Moore, Andrew J. Mungall, Jacquie Schein, Robin J. Coope, Yussanne Ma, Yongjun Zhao, Rob A. Holt, Steven J. Jones, Marco A. Marra
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background RNA-Sequencing (RNA-seq) is now commonly used to reveal quantitative spatiotemporal snapshots of the transcriptome, the structures of transcripts (splice variants and fusions) and landscapes of expressed mutations. However, standa
Externí odkaz:
https://doaj.org/article/0567feec5d9240578c381c3fcd372ebe
Autor:
Simon Haile, Richard D Corbett, Steve Bilobram, Karen Mungall, Bruno M Grande, Heather Kirk, Pawan Pandoh, Tina MacLeod, Helen McDonald, Miruna Bala, Robin J Coope, Richard A Moore, Andrew J Mungall, Yongjun Zhao, Ryan D Morin, Steven J Jones, Marco A Marra
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224578 (2019)
Next generation RNA-sequencing (RNA-seq) is a flexible approach that can be applied to a range of applications including global quantification of transcript expression, the characterization of RNA structure such as splicing patterns and profiling of
Externí odkaz:
https://doaj.org/article/9968d3d49a8b44408b7c991245913ad8
Autor:
Simon Haile, Pawan Pandoh, Helen McDonald, Richard D Corbett, Philip Tsao, Heather Kirk, Tina MacLeod, Martin Jones, Steve Bilobram, Denise Brooks, Duane Smailus, Christian Steidl, David W Scott, Miruna Bala, Martin Hirst, Diane Miller, Richard A Moore, Andrew J Mungall, Robin J Coope, Yussanne Ma, Yongjun Zhao, Rob A Holt, Steven J Jones, Marco A Marra
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178706 (2017)
Curation and storage of formalin-fixed, paraffin-embedded (FFPE) samples are standard procedures in hospital pathology laboratories around the world. Many thousands of such samples exist and could be used for next generation sequencing analysis. Retr
Externí odkaz:
https://doaj.org/article/b12c07735fcc4b01b1aaaa704c35b598
Autor:
James D. Wasmuth, Viviana Pszenny, Simon Haile, Emily M. Jansen, Alexandra T. Gast, Alan Sher, Jon P. Boyle, Martin J. Boulanger, John Parkinson, Michael E. Grigg
Publikováno v:
mBio, Vol 3, Iss 6 (2012)
ABSTRACT The Toxoplasma gondii SRS gene superfamily is structurally related to SRS29B (formerly SAG1), a surface adhesin that binds host cells and stimulates host immunity. Comparative genomic analyses of three Toxoplasma strains identified 182 SRS g
Externí odkaz:
https://doaj.org/article/29c657891aca450c82653a06a7d1225a
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24197 (2011)
Androgen receptor (AR) is a member of the nuclear receptor family of transcription factors. Upon binding to androgens, AR becomes transcriptionally active to regulate the expression of target genes that harbor androgen response elements (AREs) in the
Externí odkaz:
https://doaj.org/article/a3c0fb39443e4260855837e7062b9d8f
Autor:
Marianne D. Sadar, Stephen Plymate, Iain J. McEwan, Simon Haile, Minoru Kato, Jun Wang, Nasrin R. Mawji, Carmen Adriana Banuelos, Yu Chi Yang
Purpose: Persistent androgen receptor (AR) transcriptional activity is clinically evident in castration-resistant prostate cancer (CRPC). Therefore, AR remains as a viable therapeutic target for CRPC. All current hormonal therapies target the C-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35889222aef1241f1cccd3fe6f3a16a
https://doi.org/10.1158/1078-0432.c.6526544.v1
https://doi.org/10.1158/1078-0432.c.6526544.v1
Autor:
Marianne D. Sadar, Stephen Plymate, Iain J. McEwan, Simon Haile, Minoru Kato, Jun Wang, Nasrin R. Mawji, Carmen Adriana Banuelos, Yu Chi Yang
The Supplementary Materials and Methods contain information for the reagents and plasmids and procedures for experiments in the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77948c37f034bd50f6de27c35964d76c
https://doi.org/10.1158/1078-0432.22467128.v1
https://doi.org/10.1158/1078-0432.22467128.v1