Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Simon H. Reed"'
Autor:
Hannah L. Mackay, Helen R. Stone, George E. Ronson, Katherine Ellis, Alexander Lanz, Yara Aghabi, Alexandra K. Walker, Katarzyna Starowicz, Alexander J. Garvin, Patrick Van Eijk, Stefan A. Koestler, Elizabeth J. Anthony, Ann Liza Piberger, Anoop S. Chauhan, Poppy Conway-Thomas, Alina Vaitsiankova, Sobana Vijayendran, James F. Beesley, Eva Petermann, Eric J. Brown, Ruth M. Densham, Simon H. Reed, Felix Dobbs, Marco Saponaro, Joanna R. Morris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mammalian DNA replication relies on various DNA helicase and nuclease activities to ensure accurate genetic duplication, but how different helicase and nuclease activities are properly directed remains unclear. Here, we identify the ubiquiti
Externí odkaz:
https://doaj.org/article/28ce5cbc0af0403c82bcaf2f474d55ce
Autor:
You Zuo, Jiaqian He, Zheng Zhou, Jingjing Sun, Can Ouyang, Hui Huang, Yajuan Wang, Hairong Liu, Simon H. Reed
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 3, Pp 649-658 (2024)
In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (B
Externí odkaz:
https://doaj.org/article/f6e460879406499fb1d08933b6cbb872
Autor:
Felix M. Dobbs, Patrick van Eijk, Mick D. Fellows, Luisa Loiacono, Roberto Nitsch, Simon H. Reed
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Understanding how DNA double strand breaks (DSBs) form and are repaired in the genome depends on their accurate measurement. Here the authors describe INDUCE-seq; a DSB-detection method that simultaneously measures physiological and induced breaks th
Externí odkaz:
https://doaj.org/article/108e1aee16be4a13b26b44d7b4e2a047
Publikováno v:
BMC Chemistry, Vol 15, Iss 1, Pp 1-13 (2021)
Abstract Background Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), have been utilised to explore these context effects. BPDE is k
Externí odkaz:
https://doaj.org/article/fac036fe53d44a0ba48df6cf8840a89b
Autor:
Pierre Murat, Consuelo Perez, Alastair Crisp, Patrick van Eijk, Simon H. Reed, Guillaume Guilbaud, Julian E. Sale
Publikováno v:
Science advances. 8(45)
The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9ca74860a9b797a039223e0e0cbfa7
https://pubmed.ncbi.nlm.nih.gov/36351018
https://pubmed.ncbi.nlm.nih.gov/36351018
Autor:
Roberto Nitsch, Felix Dobbs, Patrick van Eijk, Simon H. Reed, Mick D. Fellows, Luisa Loiacono
Publikováno v:
Nature Communications
Understanding how breaks form and are repaired in the genome depends on the accurate measurement of the frequency and position of DNA double strand breaks (DSBs). This is crucial for identification of a chemical’s DNA damage potential and for safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0caa140a61d2d5e8cb6b6727788c0e
https://doi.org/10.1038/s41467-022-31702-9
https://doi.org/10.1038/s41467-022-31702-9
Autor:
Anabel Varela-Carver, Ines Figueiredo, Yang Liu, Folake Orafidiya, Ian G. Mills, Joanna Hester, Bono Johann de, Oliwia Cyran, Richard J. Bryant, Charlotte L. Bevan, Wei Yuan, Karen E. Knudsen, Hiromi Kudo, Shuang G Zhao, Robert G. Bristow, Lin Deng, Antje Neeb, Eileen Parkes, Bora Gurel, Felix Y. Feng, Yiannis Philippou, Theodora Constantin, Fadi Issa, Denisa Bogdan, Marc Lorentzen, Ronnie Rodrigues Pereira, Simon H. Reed, Felix Dobbs, Claire E. Fletcher
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c981f152b08fb16bb2e16223f4374cd7
https://doi.org/10.1530/endoabs.77.oc2.5
https://doi.org/10.1530/endoabs.77.oc2.5
Autor:
Yunfei Wang, Zheng Zhou, Ya Cui, Can Ouyang, Dan Wang, Simon H. Reed, Guifeng Wei, Jianjun Luo, Xiaomin Chen, Dongdong Zhang, Erzhong Wu, Dandan He, Runsheng Chen
Publikováno v:
Cell Death Differ
Despite recent advances in our understanding of the function of long noncoding RNAs (lncRNAs), their roles and functions in DNA repair pathways remain poorly understood. By screening a panel of uncharacterized lncRNAs to identify those whose transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1d8b35b2dce0667aeff3c51b2289cb
https://europepmc.org/articles/PMC7852670/
https://europepmc.org/articles/PMC7852670/
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002124 (2011)
Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin. We've shown th
Externí odkaz:
https://doaj.org/article/eb6e5a69610f426bbb54db87a176106f
Autor:
Folake Orafidiya, Simon H. Reed, Wei Yuan, Claire E. Fletcher, Yiannis Philippou, Emma A Murphy, Lin Deng, Ian G. Mills, Fadi Issa, Richard J. Bryant, Felix Dobbs, Shuang G. Zhao, Joanna Hester, Karen E. Knudsen, Antje Neeb, Ines Figueiredo, Damien A. Leach, Charlotte L. Bevan, Bora Gurel, Johann S. de Bono, Denisa Bogdan
Publikováno v:
Cancer Research. 81:2362-2362
NORAD (NOn-Coding RNA Activated by DNA Damage) is a highly-abundant, evolutionarily-conserved lncRNA. It maintains mitosis, DNA damage repair (DDR), and chromosomal integrity through PUM1/2 sequestration (PUM1/2 activity increases turnover of DDR fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff133058774a4f021f94198247e2467
https://doi.org/10.1158/1538-7445.am2021-2362
https://doi.org/10.1158/1538-7445.am2021-2362